scholarly journals Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA)

Autophagy ◽  
2019 ◽  
Vol 16 (2) ◽  
pp. 347-370 ◽  
Author(s):  
Philip Wing-Lok Ho ◽  
Chi-Ting Leung ◽  
Huifang Liu ◽  
Shirley Yin-Yu Pang ◽  
Colin Siu-Chi Lam ◽  
...  
Keyword(s):  
Mouse Model ◽  
Parkinson Disease ◽  
Age Dependent ◽  
Mutant Lrrk2 ◽  
Chaperone Mediated Autophagy ◽  
Knockin Mouse

Altered DAT function in a mouse model of Parkinson disease

2011 ◽  
Author(s):  
D. Leo ◽  
M. J. Bourque ◽  
C. Kortleven ◽  
E. A. Fon ◽  
L. E. Trudeau
Keyword(s):  
Mouse Model ◽  
Parkinson Disease

Deletion of murine tau gene increases tau aggregation in a human mutant tau transgenic mouse model

2010 ◽  
Vol 38 (4) ◽  
pp. 1001-1005 ◽  
Author(s):  
Kunie Ando ◽  
Karelle Leroy ◽  
Céline Heraud ◽  
Anna Kabova ◽  
Zehra Yilmaz ◽  
...  
Keyword(s):  
Mouse Model ◽  
Transgenic Mouse ◽  
Double Mutant ◽  
Transgenic Mouse Model ◽  
Tau Proteins ◽  
Dependent Manner ◽  
Age Dependent ◽  
Ad Alzheimer’S Disease ◽  
Tau Aggregation ◽  
The Brain

We have reported previously a tau transgenic mouse model (Tg30tau) overexpressing human 4R1N double-mutant tau (P301S and G272V) and that develops AD (Alzheimer's disease)-like NFTs (neurofibrillary tangles) in an age-dependent manner. Since murine tau might interfere with the toxic effects of human mutant tau, we set out to analyse the phenotype of our Tg30tau model in the absence of endogenous murine tau with the aim to reproduce more faithfully a model of human tauopathy. By crossing the Tg30tau line with TauKO (tau-knockout) mice, we have obtained a new mouse line called Tg30×TauKO that expresses only exogenous human double-mutant 4R1N tau. Whereas Tg30×TauKO mice express fewer tau proteins compared with Tg30tau, they exhibit augmented sarkosyl-insoluble tau in the brain and an increased number of Gallyas-positive NFTs in the hippocampus. Taken together, exclusion of murine tau causes accelerated tau aggregation during aging of this mutant tau transgenic model.

scholarly journals AFM Reveals Age-Dependent Micromechanical Degradation of Cardiopulmonary Tissues in a Mouse Model of Marfan Syndrome

2015 ◽  
Vol 108 (2) ◽  
pp. 295a-296a
Author(s):  
Jia-Jye Lee ◽  
Satish Rao ◽  
Josephine Galatioto ◽  
Francesco Ramirez ◽  
Kevin D. Costa
Keyword(s):  
Mouse Model ◽  
Marfan Syndrome ◽  
Age Dependent

scholarly journals Base excision repair causes age-dependent accumulation of single-stranded DNA breaks that contribute to Parkinson disease pathology

Cell Reports ◽  
2021 ◽  
Vol 36 (10) ◽  
pp. 109668
Author(s):  
Tanima SenGupta ◽  
Konstantinos Palikaras ◽  
Ying Q. Esbensen ◽  
Georgios Konstantinidis ◽  
Francisco Jose Naranjo Galindo ◽  
...  
Keyword(s):  
Parkinson Disease ◽  
Base Excision Repair ◽  
Excision Repair ◽  
Dna Breaks ◽  
Single Stranded Dna ◽  
Age Dependent ◽  
Base Excision

scholarly journals Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease

2008 ◽  
Author(s):  
Vanessa Brochard ◽  
Béhazine Combadière ◽  
Annick Prigent ◽  
Yasmina Laouar ◽  
Aline Perrin ◽  
...  
Keyword(s):  
Mouse Model ◽  
Parkinson Disease ◽  
The Brain ◽  
Cd4 Lymphocytes
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