Topical hyaluronan alone promotes corneal epithelial cell migration whereas combination with benzalkonium chloride impairs epithelial wound healing

2019 ◽  
Vol 39 (1) ◽  
pp. 13-20
Author(s):  
Satoshi Seino ◽  
Ryosuke Matsuoka ◽  
Yasunobu Masuda ◽  
Masaaki Kunou ◽  
Yuka Okada ◽  
...  
Keyword(s):  
Wound Healing ◽  
Cell Migration ◽  
Epithelial Cell ◽  
Benzalkonium Chloride ◽  
Corneal Epithelial Cell ◽  
Corneal Epithelial ◽  
Epithelial Cell Migration ◽  
Epithelial Wound Healing

scholarly journals Neolactoglycosphingolipids, Potential Mediators of Corneal Epithelial Cell Migration

1995 ◽  
Vol 270 (23) ◽  
pp. 14015-14023 ◽  
Author(s):  
Noorjahan Panjwani ◽  
Zheng Zhao ◽  
Sameer Ahmad ◽  
Zhantao Yang ◽  
Firoze Jungalwala ◽  
...  
Keyword(s):  
Cell Migration ◽  
Epithelial Cell ◽  
Corneal Epithelial Cell ◽  
Corneal Epithelial ◽  
Epithelial Cell Migration

Purinergic Signaling Involvement in Thymosin β4-mediated Corneal Epithelial Cell Migration

2020 ◽  
Vol 45 (11) ◽  
pp. 1352-1358
Author(s):  
Heung-Mo Yang ◽  
Shin Wook Kang ◽  
Jihye Sung ◽  
Kyeongsoon Kim ◽  
Hynda Kleinman
Keyword(s):  
Cell Migration ◽  
Epithelial Cell ◽  
Purinergic Signaling ◽  
Corneal Epithelial Cell ◽  
Thymosin Β4 ◽  
Corneal Epithelial ◽  
Epithelial Cell Migration

scholarly journals A Role for the Mitogen-activated Protein Kinase Kinase Kinase 1 in Epithelial Wound Healing

2006 ◽  
Vol 17 (8) ◽  
pp. 3446-3455 ◽  
Author(s):  
Maoxian Deng ◽  
Wei-Li Chen ◽  
Atsushi Takatori ◽  
Zhimin Peng ◽  
Lin Zhang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Cell Migration ◽  
Epithelial Cell ◽  
Skin Wound ◽  
Mitogen Activated Protein Kinase ◽  
Epithelial Cell Migration ◽  
Epithelial Wound Healing ◽  
Mitogen Activated Protein ◽  
Pai 1 ◽  
Protein Kinase Kinase

The mitogen-activated protein kinase kinase (MEK) kinase 1 (MEKK1) mediates activin B signals required for eyelid epithelium morphogenesis during mouse fetal development. The present study investigates the role of MEKK1 in epithelial wound healing, another activin-regulated biological process. In a skin wound model, injury markedly stimulates MEKK1 expression and activity, which are in turn required for the expression of genes involved in extracellular matrix (ECM) homeostasis. MEKK1 ablation or down-regulation by interfering RNA significantly delays skin wound closure and impairs activation of Jun NH2-terminal kinases, induction of plasminogen activator inhibitor (PAI)-1, and restoration of cell–cell junctions of the wounded epidermis. Conversely, expression of wild-type MEKK1 accelerates reepithelialization of full-thickness skin and corneal debridement wounds by mechanisms involving epithelial cell migration, a cell function that is partially abolished by neutralizing antibodies for PAI-1 and metalloproteinase III. Our data suggest that MEKK1 transmits wound signals, leading to the transcriptional activation of genes involved in ECM homeostasis, epithelial cell migration, and wound reepithelialization.

Novel materials to enhance corneal epithelial cell migration on keratoprosthesis

2010 ◽  
Vol 95 (3) ◽  
pp. 405-409 ◽  
Author(s):  
A. Karkhaneh ◽  
H. Mirzadeh ◽  
A. Ghaffariyeh ◽  
A. Ebrahimi ◽  
N. Honarpisheh ◽  
...  
Keyword(s):  
Cell Migration ◽  
Epithelial Cell ◽  
Corneal Epithelial Cell ◽  
Corneal Epithelial ◽  
Novel Materials ◽  
Epithelial Cell Migration
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