Evaluating the safety profile of focused ultrasound and microbubble-mediated treatments to increase blood-brain barrier permeability

Expert Opinion on Drug Delivery ◽

10.1080/17425247.2019.1567490 ◽

2019 ◽

Vol 16 (2) ◽

pp. 129-142 ◽

Author(s):

Dallan McMahon ◽

Charissa Poon ◽

Kullervo Hynynen

Keyword(s):

Blood Brain Barrier ◽

Safety Profile ◽

Focused Ultrasound ◽

Brain Barrier ◽

Barrier Permeability ◽

Blood Brain Barrier Permeability ◽

Blood Brain ◽

Brain Barrier Permeability

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The kinetics of blood brain barrier permeability and targeted doxorubicin delivery into brain induced by focused ultrasound

Journal of Controlled Release ◽

10.1016/j.jconrel.2012.06.012 ◽

2012 ◽

Vol 162 (1) ◽

pp. 134-142 ◽

Author(s):

Juyoung Park ◽

Yongzhi Zhang ◽

Natalia Vykhodtseva ◽

Ferenc A. Jolesz ◽

Nathan J. McDannold

Keyword(s):

Blood Brain Barrier ◽

Focused Ultrasound ◽

Brain Barrier ◽

Barrier Permeability ◽

Blood Brain Barrier Permeability ◽

Blood Brain ◽

Brain Barrier Permeability ◽

Doxorubicin Delivery ◽

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Investigation of focused ultrasound on blood-brain barrier permeability for small molecule delivery to the hippocampal formation: A preclinical investigation

Brain Stimulation ◽

10.1016/j.brs.2021.10.238 ◽

2021 ◽

Vol 14 (6) ◽

pp. 1663

Author(s):

Karen Aboody ◽

Kennedy Mahdavi ◽

Margaret Zielinski ◽

Jonathan Haroon ◽

Veronica Go ◽

...

Keyword(s):

Blood Brain Barrier ◽

Small Molecule ◽

Focused Ultrasound ◽

Hippocampal Formation ◽

Brain Barrier ◽

Barrier Permeability ◽

Blood Brain Barrier Permeability ◽

Blood Brain ◽

Preclinical Investigation ◽

Brain Barrier Permeability

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Localized difference in blood–brain barrier permeability of rat brain after focused ultrasound induced disruption

IBRO Reports ◽

10.1016/j.ibror.2019.07.1714 ◽

2019 ◽

Vol 6 ◽

pp. S550-S551

Author(s):

Hyungkyu Huh ◽

Byung Jin Jung ◽

Mun Han ◽

Juyoung Park

Keyword(s):

Rat Brain ◽

Blood Brain Barrier ◽

Focused Ultrasound ◽

Brain Barrier ◽

Barrier Permeability ◽

Blood Brain Barrier Permeability ◽

Blood Brain ◽

Brain Barrier Permeability

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Acute Inflammatory Response Following Increased Blood-Brain Barrier Permeability Induced by Focused Ultrasound is Dependent on Microbubble Dose

Theranostics ◽

10.7150/thno.21630 ◽

2017 ◽

Vol 7 (16) ◽

pp. 3989-4000 ◽

Author(s):

Dallan McMahon ◽

Kullervo Hynynen

Keyword(s):

Inflammatory Response ◽

Blood Brain Barrier ◽

Focused Ultrasound ◽

Brain Barrier ◽

Acute Inflammatory Response ◽

Barrier Permeability ◽

Blood Brain Barrier Permeability ◽

Blood Brain ◽

Brain Barrier Permeability

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Investigating the effects of dexamethasone on blood-brain barrier permeability and inflammatory response following focused ultrasound and microbubble exposure

Theranostics ◽

10.7150/thno.40908 ◽

2020 ◽

Vol 10 (4) ◽

pp. 1604-1618 ◽

Author(s):

Dallan McMahon ◽

Wendy Oakden ◽

Kullervo Hynynen

Keyword(s):

Inflammatory Response ◽

Blood Brain Barrier ◽

Focused Ultrasound ◽

Brain Barrier ◽

Barrier Permeability ◽

Blood Brain Barrier Permeability ◽

Blood Brain ◽

Brain Barrier Permeability

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Angiogenic response of rat hippocampal vasculature to focused ultrasound-mediated increases in blood-brain barrier permeability

Scientific Reports ◽

10.1038/s41598-018-30825-8 ◽

2018 ◽

Vol 8 (1) ◽

Author(s):

Dallan McMahon ◽

Ethan Mah ◽

Kullervo Hynynen

Keyword(s):

Blood Brain Barrier ◽

Focused Ultrasound ◽

Brain Barrier ◽

Barrier Permeability ◽

Blood Brain Barrier Permeability ◽

Angiogenic Response ◽

Blood Brain ◽

Brain Barrier Permeability

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Acute effects of focused ultrasound-induced increases in blood-brain barrier permeability on rat microvascular transcriptome

Scientific Reports ◽

10.1038/srep45657 ◽

2017 ◽

Vol 7 (1) ◽

Author(s):

Dallan McMahon ◽

Reina Bendayan ◽

Kullervo Hynynen

Keyword(s):

Blood Brain Barrier ◽

Focused Ultrasound ◽

Brain Barrier ◽

Acute Effects ◽

Barrier Permeability ◽

Blood Brain Barrier Permeability ◽

Blood Brain ◽

Brain Barrier Permeability

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Enhancement of blood-brain barrier permeability by the combination of bubble liposomes and high-intensity focused ultrasound

Journal of Therapeutic Ultrasound ◽

10.1186/2050-5736-3-s1-p30 ◽

2015 ◽

Vol 3 (S1) ◽

Author(s):

Yoichi Negishi ◽

Masaya Yamane ◽

Naho Kurihara ◽

Yoko Endo-Takahashi ◽

Norio Takagi ◽

...

Keyword(s):

Blood Brain Barrier ◽

High Intensity ◽

Focused Ultrasound ◽

High Intensity Focused Ultrasound ◽

Brain Barrier ◽

Barrier Permeability ◽

Blood Brain Barrier Permeability ◽

Blood Brain ◽

Brain Barrier Permeability

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An advanced focused ultrasound protocol improves the blood-brain barrier permeability and doxorubicin delivery into the rat brain

Journal of Controlled Release ◽

10.1016/j.jconrel.2019.10.044 ◽

2019 ◽

Vol 315 ◽

pp. 55-64 ◽

Author(s):

Byeongjin Jung ◽

Hyungkyu Huh ◽

Eun-hee Lee ◽

Mun Han ◽

Juyoung Park

Keyword(s):

Rat Brain ◽

Blood Brain Barrier ◽

Focused Ultrasound ◽

Brain Barrier ◽

Barrier Permeability ◽

Blood Brain Barrier Permeability ◽

Blood Brain ◽

Brain Barrier Permeability ◽

Doxorubicin Delivery

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Focused Ultrasound-Induced Neurogenesis Requires an Increase in Blood-Brain Barrier Permeability

PLoS ONE ◽

10.1371/journal.pone.0159892 ◽

2016 ◽

Vol 11 (7) ◽

pp. e0159892 ◽

Author(s):

Skyler J. Mooney ◽

Kairavi Shah ◽

Sharon Yeung ◽

Alison Burgess ◽

Isabelle Aubert ◽

...

Keyword(s):

Blood Brain Barrier ◽

Focused Ultrasound ◽

Brain Barrier ◽

Barrier Permeability ◽

Blood Brain Barrier Permeability ◽

Blood Brain ◽

Brain Barrier Permeability

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