Role of necroptosis of alveolar macrophages in acute lung inflammation of mice exposed to titanium dioxide nanoparticles

2022 ◽  
pp. 1-19
Author(s):  
Tomoya Sagawa ◽  
Akiko Honda ◽  
Raga Ishikawa ◽  
Natsuko Miyasaka ◽  
Megumi Nagao ◽  
...  
2002 ◽  
Vol 282 (6) ◽  
pp. L1245-L1252 ◽  
Author(s):  
Ulrich a. Maus ◽  
M. Audrey Koay ◽  
Tim Delbeck ◽  
Matthias Mack ◽  
Monika Ermert ◽  
...  

Intratracheal instillation of the monocyte chemoattractant JE/monocyte chemoattractant protein (MCP)-1 in mice was recently shown to cause increased alveolar monocyte accumulation in the absence of lung inflammation, whereas combined JE/MCP-1/lipopolysaccharide (LPS) challenge provoked acute lung inflammation with early alveolar neutrophil and delayed alveolar monocyte influx. We evaluated the role of resident alveolar macrophages (rAM) in these leukocyte recruitment events and related phenomena of lung inflammation. Depletion of rAM by pretreatment of mice with liposomal clodronate did not affect the JE/MCP-1-driven alveolar monocyte accumulation, despite the observation that rAM constitutively expressed the JE/MCP-1 receptor CCR2, as analyzed by flow cytometry and immunohistochemistry. In contrast, depletion of rAM largely suppressed alveolar cytokine release as well as neutrophil and monocyte recruitment profiles upon combined JE/MCP-1/LPS treatment. Despite this strongly attenuated alveolar inflammatory response, increased lung permeability was still observed in rAM-depleted mice undergoing JE/MCP-1/LPS challenge. Lung leakage was abrogated by codepletion of circulating neutrophils or administration of anti-CD18. Collectively, rAM are not involved in JE/MCP-1-driven alveolar monocyte recruitment in noninflamed lungs but largely contribute to the alveolar cytokine response and enhanced early neutrophil and delayed monocyte influx under inflammatory conditions (JE/MCP-1/LPS deposition). Loss of lung barrier function observed under these conditions is rAM independent but involves circulating neutrophils via β2-integrin engagement.


2014 ◽  
Vol 11 (1) ◽  
Author(s):  
Raymond LC Kao ◽  
Xuemei Xu ◽  
Anargyros Xenocostas ◽  
Neil Parry ◽  
Tina Mele ◽  
...  

2020 ◽  
Vol 12 (29) ◽  
pp. 32446-32460 ◽  
Author(s):  
Elisa Parra-Ortiz ◽  
Sara Malekkhaiat Häffner ◽  
Thomas Saerbeck ◽  
Maximilian W. A. Skoda ◽  
Kathryn L. Browning ◽  
...  

PLoS ONE ◽  
2010 ◽  
Vol 5 (4) ◽  
pp. e10183 ◽  
Author(s):  
Adam A. Anas ◽  
Joppe W. R. Hovius ◽  
Cornelis van 't Veer ◽  
Tom van der Poll ◽  
Alex F. de Vos

2014 ◽  
Vol 33 (5) ◽  
pp. 1023-1029 ◽  
Author(s):  
Huanhua Wang ◽  
Robert M. Burgess ◽  
Mark G. Cantwell ◽  
Lisa M. Portis ◽  
Monique M. Perron ◽  
...  

2013 ◽  
Vol 110 (13) ◽  
pp. 5205-5210 ◽  
Author(s):  
T. Murata ◽  
K. Aritake ◽  
Y. Tsubosaka ◽  
T. Maruyama ◽  
T. Nakagawa ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document