scholarly journals Development of a mechanism of action-reflective, dual target cell-based reporter bioassay for a bispecific monoclonal antibody targeting human CTLA-4 and PD-1

mAbs ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 1914359
Author(s):  
Weimin Chen ◽  
Madhu Pandey ◽  
Hong Sun ◽  
Andrea Rolong ◽  
Mingyan Cao ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Mechanism Of Action ◽  
Target Cell ◽  
Bispecific Monoclonal Antibody ◽  
Antibody Targeting ◽  
Dual Target

Human neutrophil interactions of a bispecific monoclonal antibody targeting tumor and human Fcγ RIII

1996 ◽  
Vol 42 (3) ◽  
pp. 141-150 ◽  
Author(s):  
L. M. Weiner ◽  
R. Katherine Alpaugh ◽  
Anne R. Amoroso ◽  
Gregory P. Adams ◽  
David B. Ring ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Human Neutrophil ◽  
Bispecific Monoclonal Antibody ◽  
Antibody Targeting

A phase I trial of intravenous catumaxomab: a bispecific monoclonal antibody targeting EpCAM and the T cell coreceptor CD3

2015 ◽  
Vol 75 (5) ◽  
pp. 1065-1073 ◽  
Author(s):  
Morten Mau-Sørensen ◽  
Christian Dittrich ◽  
Rodrigo Dienstmann ◽  
Ulrik Lassen ◽  
Wilfried Büchler ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
T Cell ◽  
Phase I ◽  
Phase I Trial ◽  
Bispecific Monoclonal Antibody ◽  
Antibody Targeting

Hair Growth in a Patient with Alopecia Areata on Tocilizumab

2021 ◽  
pp. 1-5
Author(s):  
Chloe J. Walker ◽  
Kelly E. Flanagan ◽  
James T. Pathoulas ◽  
Isabel Pupo Wiss ◽  
Maryanne M. Senna
Keyword(s):  
Monoclonal Antibody ◽  
Autoimmune Disease ◽  
Hair Loss ◽  
Alopecia Areata ◽  
Interleukin 6 ◽  
Hair Growth ◽  
Posterior Uveitis ◽  
Case Presentation ◽  
Antibody Targeting ◽  
Growth Changes

<b><i>Introduction:</i></b> Tocilizumab (TCZ), a recombinant humanized antihuman monoclonal antibody targeting interleukin-6 (IL-6) signaling, is often utilized in the management of autoimmune disease. Few reports have demonstrated hair growth changes in patients on TCZ. <b><i>Case Presentation:</i></b> Herein, we review the literature and report a 21-year-old woman with progressive alopecia areata (AA) presenting with AA improvement while on TCZ for concomitant posterior uveitis. <b><i>Discussion:</i></b> Our case demonstrates the potential ability of TCZ to disrupt IL-6 signaling involved in AA, leading to hair loss and regrowth.

scholarly journals A humanized monoclonal antibody targeting the β7 integrin selectively blocks intestinal homing of T lymphocytes

2011 ◽  
Vol 162 (8) ◽  
pp. 1855-1870 ◽  
Author(s):  
EG Stefanich ◽  
DM Danilenko ◽  
H Wang ◽  
S O'Byrne ◽  
R Erickson ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
T Lymphocytes ◽  
Humanized Monoclonal Antibody ◽  
Antibody Targeting
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