Hair Growth in a Patient with Alopecia Areata on Tocilizumab

2021 ◽  
pp. 1-5
Author(s):  
Chloe J. Walker ◽  
Kelly E. Flanagan ◽  
James T. Pathoulas ◽  
Isabel Pupo Wiss ◽  
Maryanne M. Senna
Keyword(s):  
Monoclonal Antibody ◽  
Autoimmune Disease ◽  
Hair Loss ◽  
Alopecia Areata ◽  
Interleukin 6 ◽  
Hair Growth ◽  
Posterior Uveitis ◽  
Case Presentation ◽  
Antibody Targeting ◽  
Growth Changes

<b><i>Introduction:</i></b> Tocilizumab (TCZ), a recombinant humanized antihuman monoclonal antibody targeting interleukin-6 (IL-6) signaling, is often utilized in the management of autoimmune disease. Few reports have demonstrated hair growth changes in patients on TCZ. <b><i>Case Presentation:</i></b> Herein, we review the literature and report a 21-year-old woman with progressive alopecia areata (AA) presenting with AA improvement while on TCZ for concomitant posterior uveitis. <b><i>Discussion:</i></b> Our case demonstrates the potential ability of TCZ to disrupt IL-6 signaling involved in AA, leading to hair loss and regrowth.

Disorders of Hair

2013 ◽  
Author(s):  
James Q Del Rosso
Keyword(s):  
Hair Loss ◽  
Alopecia Areata ◽  
Hair Growth ◽  
Growth Cycle ◽  
Hair Follicles ◽  
Common Type ◽  
Diagnosis And Treatment ◽  
Basic Knowledge ◽  
Androgenetic Alopecia ◽  
Broad Overview

A basic knowledge of the hair growth cycle is needed to evaluate disorders of hair growth. This chapter presents a broad overview of the physiology and evaluation of hair growth, as well as discussions of specific types of alopecia. The epidemiology, pathogenesis, diagnosis, and treatment of androgenetic alopecia, the most common type of nonscarring hair loss, are covered. Diffuse hair shedding is generalized hair loss over the entire scalp. Diagnosis and treatment of telogen effluvium, anagen arrest (anagen effluvium), and other causes of diffuse hair shedding are covered in detail. Alopecia areata, typically characterized by patchy hair loss; cicatricial alopecia, which results from permanent scarring of the hair follicles; and miscellaneous causes of hair loss are also discussed. Tables list the causes of diffuse and cicatricial alopecia, telogen effluvium, and miscellaneous chemicals and categories of drugs that can cause alopecia, as well as miscellaneous causes of hair loss. Included is an algorithm outlining the approach to diagnosing nonscarring alopecia, as well as a variety of clinical photographs. This review contains 9 highly rendered figures, 6 tables, and 42 references.

Pediatric alopecia areata

2020 ◽  
Vol 16 ◽  
Author(s):  
Rebecca Afford ◽  
Alexander K. C. Leung ◽  
Joseph M. Lam
Keyword(s):  
Autoimmune Disease ◽  
Hair Loss ◽  
Alopecia Areata ◽  
English Language ◽  
Treatment Options ◽  
Atopic Disease ◽  
Unknown Etiology ◽  
Stressful Event ◽  
Search Term ◽  
Family Medical History

Background: Alopecia areata (AA) is a non-scarring hair loss disorder of autoimmune etiology. Objective: To familiarize physicians with the clinical presentation, diagnosis, evaluation, and management of pediatric alopecia areata. Methods: The search term "Alopecia areata" was entered into a Pubmed search. A narrow scope was applied to the categories of "epidemiology", "clinical diagnosis", "investigations", "comorbidities", and "treatment". Meta-analyses, randomized controlled trials, clinical trials, observational studies, and reviews were included. Only papers published in the English language were included. A descriptive, narrative synthesis was provided of the retrieved articles. Results: AA is an autoimmune disease of unknown etiology. It is the third most common dermatologic presentation in children with a lifetime risk of 1-2%. Diagnosing AA can be made on the basis of the history and clinical findings. Patients will often present with patchy, non-scarring hair loss generally affecting the scalp. History may reveal a personal or family medical history of autoimmune or atopic disease or a recent stressful event. Tricoscopic examination will classically show “exclamation point hairs” and “yellow dots”. Nonspecific nail changes may be present. Other clinical variants include alopecia totalis, alopecia universalis, ophiasis, sisaipho, and Canitis subita. There are multiple treatment options for AA including conservative treatment, and topical, oral, and injectable medications. Conclusion: AA is an autoimmune disease with a heterogenous presentation and unpredictable clinical course. Although there is no cure for AA, there are many current treatment options available to help manage this disfiguring disease.

scholarly journals A Multimodal Hair-Loss Treatment Strategy Using a New Topical Phytoactive Formulation: A Report of Five Cases

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Sanusi Umar ◽  
Marissa J. Carter
Keyword(s):  
Side Effects ◽  
Hair Loss ◽  
Hair Growth ◽  
Case Series ◽  
Previous Treatment ◽  
Case Presentation ◽  
Topical Minoxidil ◽  
Continued Use ◽  
New Formulation ◽  
Infant Stage

Introduction. Current approved medications for hair loss, such as topical minoxidil and oral finasteride, may have suboptimal efficacy or side effects precluding continued use in some patients. Thus, we report an evaluation of the efficacy, safety, and tolerability of a new topical botanical formulation -GASHEE containing over 12 phytoactive ingredients that affect multiple targets in the cascade of pathophysiologic events that cause hair loss. Five patients with various hair-loss conditions, including cases of previous treatment failures, are presented. Case Presentation. This is a case series of four women and one man with hair loss due to various causes, four of whom had failed minoxidil treatment for over a year. All patients used the topical treatment as a sole therapy for at least 3 months before the documentation of outcomes, which involved interval changes noted through each patient’s account, direct observation, and photography. Discussion. In all patients, we observed significant improvements in hair regrowth in the nape, crown, vertex, and temple areas after 3–15 months of treatment. All patients were highly satisfied with their results and reported no adverse events. Although the use of botanicals in the treatment of hair loss is in an infant stage, the new formulation used in this study demonstrated a good efficacy related to hair growth, warranting further evaluation.

scholarly journals Efficacy of plum blossom acupuncture on alopecia areata – A case report

2021 ◽  
pp. 395-397
Author(s):  
Sujithra Sreekumari Thanudhas
Keyword(s):  
Case Report ◽  
Hair Loss ◽  
Alopecia Areata ◽  
Pharmacological Treatment ◽  
Hair Growth ◽  
Genetic Factors ◽  
The Past ◽  
Autoimmune Condition

Alopecia areata (AA) is a complex autoimmune condition that causes non-scarring hair loss and may present at any age. It typically presents with sharply demarcated round patches of hair loss. AA presents heterogeneously and is influenced by both environmental and genetic factors. There is no effective pharmacological treatment currently available for this disorder so far. We had an opportunity to treat a patient with AA using acupuncture. The patient was a 23-year-old male who presented to us with a complaint of sudden hair loss in patches in two demarcated round areas in a diameter of 2–3 cm on the back of the head for the past year. He was diagnosed as AA by AA progression index. After a long treatment course of about 3 months with acupuncture, this patient showed significant hair growth.

scholarly journals Effective treatment of alopecia universalis with oral tofacitinib: A case report

2021 ◽  
Vol 12 (1) ◽  
pp. 33-36
Author(s):  
Lenah Shaikh ◽  
Amnah Almulhim ◽  
Manal Al Rabai ◽  
Yasir Shaikh
Keyword(s):  
Case Report ◽  
Autoimmune Disease ◽  
Effective Treatment ◽  
Hair Loss ◽  
Alopecia Areata ◽  
The Body ◽  
Entire Body ◽  
Alopecia Universalis ◽  
One Year ◽  
Persistent Response

Alopecia areata is a common autoimmune disease presenting itself with patches of hair loss on the scalp, eyebrows, eyelashes, or any part of the body. It may manifest itself as a single patch, involving the entire scalp (alopecia totalis), or affecting the entire body, thus the name alopecia universalis. Multiple lines of treatment may be employed, but no single most effective treatment exists, especially if the condition is generalized and, thus, becomes more difficult to treat. Herein, we report a case of alopecia universalis treated with oral tofacitinib with an excellent and persistent response one year after.

Systematic Desensitization as a Component for Treatment of Alopecia Areata: A Case Study

1980 ◽  
Vol 46 (3) ◽  
pp. 875-881 ◽  
Author(s):  
Judith E. Stowe ◽  
Edward Goldenberg
Keyword(s):  
Hair Loss ◽  
Alopecia Areata ◽  
Hair Growth ◽  
Physiological Changes ◽  
Autonomic Activity ◽  
Systematic Desensitization ◽  
Hair Regrowth ◽  
History Of

Systematic desensitization and relaxation were employed to examine their effects on hair growth in a 20-yr.-old male with a 4-yr. history of alopecia areata. Six bald scalp patches were photographed over 6 mo.; 2 ordered hierarchies involving interpersonal and compulsive themes were presented in 8 treatment sessions. Results indicated nearly complete hair regrowth over the 6 mo., with no new appearances of bald patches. Both rate and duration of growth exceeded that reported in dermatological literature, suggesting that autonomic activity associated with anxiety and nervousness are correlated with physiological changes precipitating hair loss.

Alopecia areata in patients with systemic lupus erythematosus treated with belimumab: a plausible association

Lupus ◽  
2020 ◽  
Vol 29 (4) ◽  
pp. 426-430 ◽  
Author(s):  
O Shamriz ◽  
S H Yahia ◽  
Y Ramot ◽  
N Agmon-Levin ◽  
Y Tal
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Monoclonal Antibody ◽  
Hair Loss ◽  
Alopecia Areata ◽  
Lupus Erythematosus ◽  
B Lymphocyte ◽  
Systemic Lupus ◽  
Immune Mediated ◽  
B Lymphocyte Stimulator ◽  
Current Report

Belimumab, an anti-B-lymphocyte stimulator monoclonal antibody, was recently approved for the treatment of systemic lupus erythematosus. Alopecia areata is characterized by an acute immune-mediated hair loss. Herein, we report on three adult systemic lupus erythematosus patients who developed alopecia areata in association with belimumab treatment. Alopecia areata was resolved in all three patients and belimumab was discontinued in two of them. Thus, in the current report, we explore the plausible link between alopecia areata and belimumab.

Disorders of Hair

2013 ◽  
Author(s):  
James Q Del Rosso
Keyword(s):  
Hair Loss ◽  
Alopecia Areata ◽  
Hair Growth ◽  
Growth Cycle ◽  
Hair Follicles ◽  
Common Type ◽  
Diagnosis And Treatment ◽  
Basic Knowledge ◽  
Androgenetic Alopecia ◽  
Broad Overview

A basic knowledge of the hair growth cycle is needed to evaluate disorders of hair growth. This chapter presents a broad overview of the physiology and evaluation of hair growth, as well as discussions of specific types of alopecia. The epidemiology, pathogenesis, diagnosis, and treatment of androgenetic alopecia, the most common type of nonscarring hair loss, are covered. Diffuse hair shedding is generalized hair loss over the entire scalp. Diagnosis and treatment of telogen effluvium, anagen arrest (anagen effluvium), and other causes of diffuse hair shedding are covered in detail. Alopecia areata, typically characterized by patchy hair loss; cicatricial alopecia, which results from permanent scarring of the hair follicles; and miscellaneous causes of hair loss are also discussed. Tables list the causes of diffuse and cicatricial alopecia, telogen effluvium, and miscellaneous chemicals and categories of drugs that can cause alopecia, as well as miscellaneous causes of hair loss. Included is an algorithm outlining the approach to diagnosing nonscarring alopecia, as well as a variety of clinical photographs. This review contains 9 highly rendered figures, 6 tables, and 42 references.

scholarly journals Efektifitas Panax Ginseng terhadap Alopecia

2020 ◽  
Vol 2 (1) ◽  
pp. 71-78
Author(s):  
Karunia Santi ◽  
Made Merta Jaya
Keyword(s):  
Panax Ginseng ◽  
Hair Loss ◽  
Alopecia Areata ◽  
Hair Growth ◽  
Hair Cycle ◽  
Androgenic Alopecia ◽  
Traditional Medicines ◽  
Three Stages ◽  
Growth Promoting ◽  
Underlying Mechanisms

Aspek fungsional rambut pada kepala tidak hanya untuk melindungi dari radiasi matahari dan paparan panas / dingin, tetapi juga untuk berkontribusi pada penampilan dan kepribadian seseorang. Kerontokan rambut progresif memiliki dampak kosmetik dan sosial. Rambut mengalami tiga tahap siklus rambut: fase anagen, catagen, dan telogen. Melalui kehilangan siklus dan pertumbuhan rambut baru, jumlah rambut tetap relatif konstan. Berbagai faktor, seperti hormon, status gizi, dan paparan radiasi, racun lingkungan, dan obat-obatan, dapat memengaruhi pertumbuhan rambut. Androgen adalah faktor terpenting yang menyebabkan alopesia androgenik. Bentuk lain dari kerontokan rambut termasuk kerontokan rambut imunogenik, yaitu alopecia areata. Meskipun sejumlah terapi, seperti finasteride dan minoxidil, adalah obat yang disetujui pencarian terhadap obat obatan alami atau tradisional tetap diperhitungkan salah satunya adalah ginseng. Sejumlah produk - produk sampo dan kondisioner memsukan bagian ginseng, telah menunjukkan pertumbuhan rambut - mempromosikan efek dalam sejumlah besar studi praklinis. Penelitian ini merupakan studi literature review.Tujuan dari tinjauan ini adalah melihat potensi ginseng dan metabolitnya pada pencegahan rambut rontok dan mekanisme yang mendasarinya.  Kata kunci: alopecia, kerontokan rambut, ginseng  EFFECTIVENESS OF PANAX GINSENG ON ALOPECIA  ABSTRACT The functional aspect of hair on the head is not only to protect from sun radiation and heat / cold exposure, but also to contribute to one's appearance and personality. Progressive hair loss has cosmetic and social effects. Hair experiences three stages of the hair cycle: anagen, catagen, and telogen phases. Through cycle loss and new hair growth, the amount of hair remains relatively constant. Various factors, such as hormones, nutritional status, and radiation exposure, environmental toxins, and medications, can affect hair growth. Androgens are the most important factor causing androgenic alopecia. Other forms of hair loss include immunogenic hair loss, namely alopecia areata. Although a number of therapies, such as finasteride and minoxidil, are drugs that are approved by the search for natural or traditional medicines, one of which is still considered ginseng. A number of shampoo and conditioner products, which have a part of ginseng, have shown hair growth - promoting effects in a large number of preclinical studies. This study used literatur review. The purpose of this review is to look at the potential of ginseng and its metabolites in the prevention of hair loss and the underlying mechanisms.  Keywords:alopecia, hair loss, ginseng

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