Cryptosporidium infection among people living with HIV/AIDS in Ethiopia: a systematic review and meta-analysis

We conducted a systematic review research and meta-analysis to reveal the relationship between the risk of chronic diarrhea and Cryptosporidium infection in people living with HIV in Southeast Asia. We performed online peer-reviewed literature research from January 2005 to December 2017, which included PubMed, Science Direct, ProQuest, EBSCO, Cochrane, and Web of Science databases. Calculation of size effects in the meta-analysis was performed by STATA 13.0 software to estimate relative risks (RRs) with 95% confidence intervals (CIs) for any associations. Seven cross-sectional research articles were recruited in this study based on the inclusion and exclusion criteria. Our analysis revealed a significant relationship between cryptosporidiosis and the risk of chronic diarrhea in people living with HIV, with RR = 1.325; 95% CI = 1.157 to 1.517; and P < .000. Our results suggested that cryptosporidiosis increases the risk of chronic diarrhea, and low CD4+ lymphocyte cell counts aggravate the degree of diarrhea. Therefore, clinicians should be more aware in treating HIV-positive people, especially those with low CD4+ cell counts, and we suggest that Cryptosporidium laboratory examinations be conducted immediately.

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Effect of pharmacist care on clinical outcomes among people living with HIV/AIDS: A systematic review and meta-analysis

Research in Social and Administrative Pharmacy ◽

10.1016/j.sapharm.2021.07.020 ◽

2021 ◽

Author(s):

Ali Ahmed ◽

Juman Abdulelah dujaili ◽

Inayat Ur Rehman ◽

Alice Chuah Lay Hong ◽

Furqan Khurshid Hashmi ◽

...

Keyword(s):

Systematic Review ◽

Clinical Outcomes ◽

Meta Analysis ◽

People Living With Hiv ◽

Living With Hiv ◽

Pharmacist Care ◽

Hiv Aids

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The prevalence of thrombocytopenia and leucopenia among people living with HIV/AIDS in Ethiopia: A systematic review and meta-analysis

PLoS ONE ◽

10.1371/journal.pone.0257630 ◽

2021 ◽

Vol 16 (9) ◽

pp. e0257630

Author(s):

Habtye Bisetegn ◽

Hussien Ebrahim

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Hematological Parameters ◽

Random Effect ◽

People Living With Hiv ◽

Significant Heterogeneity ◽

Aids Patients ◽

Pooled Prevalence ◽

Living With Hiv ◽

Hiv Aids

Introduction Thrombocytopenia and leucopenia are frequently encountered hematological disorders among people living with HIV/AIDS. This systematic review and meta-analysis were aimed to indicate the national prevalence of thrombocytopenia and leucopenia among HIV/AIDS patients. Methods This systematic review and meta-analysis was conducted following the preferred reporting items for systematic review and meta-analysis (PRISMA) guidelines. A systematic search was conducted from February 01, 2021 to April 02, 2021 using electronic databases Google Scholar, PubMed, Web of Sciences, Google, EMBASE, SCOPUS and ResearchGate. The quality of the included studies was assessed using Newcastle—Ottawa Quality Assessment Scale (NOS) adapted for cross-sectional studies. Data analysis was done using STATA version 14 using metan commands. Random effect meta-analysis was used to estimate the pooled prevalence of thrombocytopenia and leucopenia among people living with HIV/AIDS in Ethiopia. Result Of the 349 initially searched articles, 90 were assessed for eligibility and only 13 articles published from 2014 to 2020 were included in the final meta-analysis. A total of 3854 participants were involved in the included studies. The pooled prevalence of thrombocytopenia was 9.69% (95%CI; 7.40–11.97%). Significant heterogeneity was observed with I2 value of 84.7%. Thrombocytopenia was 11.91% and 5.95% prevalent among HAART naive and HAART exposed HIV/AIDS patients, respectively. The pooled prevalence of leucopenia among HIV/AIDS patients was 17.31% (95%CI: 12.37–22.25%). Conclusion This study showed a high prevalence of thrombocytopenia and leucopenia among people living with HIV/AIDS, indicating the necessity of regular screening of HIV seropositive patients for different hematological parameters and providing treatment.

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