scholarly journals LINC02163 regulates growth and epithelial-to-mesenchymal transition phenotype via miR-593-3p/FOXK1 axis in gastric cancer cells

2018 ◽  
Vol 46 (sup2) ◽  
pp. 607-615 ◽  
Author(s):  
Lemei Dong ◽  
Huisuo Hong ◽  
Xiaowei Chen ◽  
Zhiming Huang ◽  
Wei Wu ◽  
...  
2017 ◽  
Vol 82 (6) ◽  
pp. 707-714 ◽  
Author(s):  
Jing Feng ◽  
Xiaojuan Wang ◽  
Weihua Zhu ◽  
Si Chen ◽  
Changwei Feng

2021 ◽  
Vol 16 (1) ◽  
pp. 27-33
Author(s):  
Yi Zhou ◽  
Liguo Wang ◽  
Hui Lin ◽  
Yunxia Wang ◽  
Kezhu Hou

This study was designed to evaluate the anti-cancer effects of bufalin against the human gastric cancer cells and unveil the underlying mechanism. The results showed that bufalin inhibited the proliferation and colony formation of the MGC-803 gastric cancer cells and exhibited an IC50 of 10 μM. These antiproliferative effects were found to be due to the induction of G2/M cell cycle arrest. The G2/M cell cycle arrest was also concomitant with inhibition of cdc2, cdc25 and cyclin B1. Furthermore, bufalin suppressed the epithelial-to-mesenchymal transition, migration, and invasion of the MGC-803 gastric cancer cells. The Western blot analysis revealed that bufalin exerted its effects via deactivation of EK/ERK signaling pathway. Taken together, these results suggest the potential of bufalin as the lead molecule for the development of chemotherapy for gastric cancer.  


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