Complementary use of scintimammography with 99m-Tc-MIBI to triple diagnostic procedure in palpable and non-palpable breast lesions

2003 ◽  
Vol 44 (3) ◽  
pp. 288-293 ◽  
Author(s):  
B. Wilczek ◽  
P. Aspelin ◽  
B. Boné ◽  
A. Pegerfalk ◽  
J. Frisell ◽  
...  
Keyword(s):  
Diagnostic Procedure ◽  
Needle Aspiration ◽  
Breast Lesions ◽  
Breast Cancers ◽  
Clinical Value ◽  
Complementary Method ◽  
Non Palpable Lesions ◽  
Palpable Breast ◽  
Additional Value ◽  
A Prospective Study

Purpose: The aim of this study was to determine the clinical value of scintimammography with 99m-Tc-MIBI ( Sc) as a complementary method to the triple diagnostic procedure in the diagnosis of breast lesions. Material and Methods: Ninety-six consecutive patients with 65 palpable and 54 non-palpable breast lesions were included in a prospective study. All lesions were evaluated by clinical examination, mammography and fine-needle-aspiration cytology (FNAC), called triple diagnostic procedure ( TD). Prone planar scintimammography with 99m-Tc-MIBI was performed in all patients. Five groups were defined for diagnosis: 1 = normal; 2 = benign; 3 = probably benign; 4 = highly suspect of malignancy; and 5 = malignant. In the calculations, groups 1–3 were considered benign, and 4–5 malignant. All lesions were excised and examined histologically. The additional value of Sc +  TD procedure was studied separately for palpable and non-palpable lesions. Results: Histologically, 83 malignant and 36 benign lesions were found in the 119 breast lesions. Sensitivity for malignancy in palpable lesions of TD alone and of the combination TD +  Sc were 95.6% and 100%, respectively. Sensitivity for malignancy in non-palpable lesions of TD and TD +  Sc was 89.1% and 97.2%, respectively. Conclusion: Adding scintimammography to the triple diagnostic procedure increased the sensitivity for the detection of both palpable and non-palpable breast cancers, but decreased the specificity.

201Tl Scintigraphy in the Evaluation of Palpable and Nonpalpable Breast Lesions: Correlation with Mammography and Ultrasonography

1997 ◽  
Vol 36 (08) ◽  
pp. 282-288 ◽  
Author(s):  
T. Atasever ◽  
A. Özdemir ◽  
I. Öznur ◽  
N. I. Karabacak ◽  
N. Gökçora ◽  
...  
Keyword(s):  
Final Diagnosis ◽  
Lower Sensitivity ◽  
Breast Lesions ◽  
Breast Cancers ◽  
Combined Use ◽  
Malignant Breast ◽  
Malignant Lesions ◽  
Benign Breast Lesions ◽  
Palpable Breast ◽  
Metastatic Sites

Summary Aim: Our goal was to determine the clinical usefulness of TI-201 to identify breast cancer in patients with suspicious breast lesions on clinical examination, and/or abnormal radiologic (mammography and/or ultrasonography) findings. Methods: TI-201 scintigraphy were performed in sixty-eight patients with 70 breast abnormalities (51 palpable, 19 nonpalpable) and compared with mammography and ultrasonography (US). Early (15 min) and late (3 h) images of the breasts were obtained following the injection of 111 MBq (3 mCi) of TI-201. Visual and semiquantitative interpretation was performed. Results: Final diagnosis confirmed 52 malignant breast lesions and 18 benign conditions. TI-201 visualized 47 of 52 (90%) overall malignant lesions. Thirty-eight of 40 (95%) palpable and 9 of 12 (75%) nonpalpable breast cancers were detected by TI-201 scintigraphy. The smallest mass lesion detected by TI-201 measured 1.5x1.0 cm. Eleven breast lesions were interpreted as indeterminate by mammography and/or sonography. TI-201 scintigraphy excluded malignancy in 7 of 8 (88%) patients with benign breast lesions interpreted as indeterminate. Five of the 18 (28%) benign breast lesions showed TI-201 uptake. None of the fibroadenoma and fibrocystic changes accumulated TI-201. TI-201 scintigraphy, mammography and ultrasonography showed 90%, 92%, 85% overall sensitivity and 72%, 56%, 61% overall specificity respectively. Twenty-one of the 28 (75%) axillary nodal metastatic sites were also detected by TI-201. In malignant and benign lesions, early and late lesion/contralateral normal side (L/N) ratios were 1.58 ± 0.38 (mean ± SD) and 1.48 ± 0.32 (p >0.05), 1.87 ± 0.65 and 1.34 ± 0.20 (p<0.05) respectively. The mean early and late L/N ratios of malignant and benign groups did not show statistical difference (p>0.05). Conclusion: Overall, TI-201 scintigraphy was the most specific of the three methods and yielded favourable results in palpable breast cancers, while it showed lower sensitivity in nonpalpable cancers and axillary metastases. Combined use of TI-201 scintigraphy with mammography and US seems to be useful in difficult cases, such as dense breasts and indeterminate breast lesions.

Complementary Use of Scintimammography with 99m-Tc-Mibi to Triple Diagnostic Procedure in Palpable and Non-Palpable Breast Lesions

2003 ◽  
Vol 44 (3) ◽  
pp. 288-293
Author(s):  
B. Wilczek ◽  
P. Aspelin ◽  
B. Bone ◽  
A. Pegerfalk ◽  
J. Frisell ◽  
...  
Keyword(s):  
Diagnostic Procedure ◽  
Breast Lesions ◽  
Palpable Breast

scholarly journals Fine Needle Aspiration Cytology Findings of Breast Lesions in Western Region of Nepal

2018 ◽  
Vol 16 (2) ◽  
pp. 9-12
Author(s):  
Pragya Gautam Ghimire ◽  
Prasanna Ghimire ◽  
Sharmila Gupta
Keyword(s):  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Parasitic Infection ◽  
Age Groups ◽  
Needle Aspiration ◽  
Breast Lesions ◽  
Breast Cancers ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Needle Aspiration Cytology

Aim: Breast cancer is the most common neoplasm worldwide. Fine needle aspiration cytology is a minimally invasive, highly sensitive and cost effective investigation for breast lesions. The aim of our study was to evaluate the spectrum of fine needle aspiration cytology findings of breast lesions. Material and Methods: It was a prospective study conducted in the Department of Pathology during a 2 year period from Jun 2016- May 2018. A total of 284 patients with breast lesions were subjected to ultrasound guided fine needle aspiration cytology. Result: The age of presentation ranged from 13 years to 81 years with a mean age of 34.9±13.5 years. Most common age group for breast lesions was in 21-30 age groups (39.1%). Fibro adenoma was the most common benign pathology (26.8%) followed by fibrocystic changes (26.4%). Malignancy was noted in 16.2% with majority in the 41-50 age groups. Parasitic infection was noted in 2 cases. Conclusion: Screening of breast lesions is warranted resulting in significant reduction of morbidity and mortality related to breast cancers. Fine needle cytology plays a pivotal role in the overall management of breast lesions.

Relationship of recent pregnancy and cytologic atypia in the contralateral breast of patients with breast cancer.

2011 ◽  
Vol 29 (27_suppl) ◽  
pp. 149-149
Author(s):  
E. Revesz ◽  
C. M. Zalles ◽  
D. Ivancic ◽  
K. P. Bethke ◽  
N. M. Hansen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Scoring Systems ◽  
Needle Aspiration ◽  
Contralateral Breast ◽  
Cancer Risk Assessment ◽  
Breast Cancers ◽  
Breast Cancer Risk Assessment ◽  
Cytological Abnormalities ◽  
Cytological Features ◽  
A Prospective Study

149 Background: Although early parity protects against breast cancer later in life, it is a risk factor in the years following pregnancy, particularly when child-bearing is delayed. In a separate study, we have reported that these pregnancy-associated breast cancers (PABC) are more likely to be hormone receptor (HR) negative; we have previously found that random fine needle aspiration (rFNA) of the contralateral breast (CB) frequently have atypia in women with HR negative breast cancer. We now report an analysis of the cytological features of contralateral rFNA in relation to recent parity, with the goal of assessing cytological features which may be risk factors for PABC. Methods: Women with breast cancer undergoing surgery between 2006 and 2008 were enrolled in a prospective study of rFNA of the CB. Cytological analysis was performed on all the samples, using two scoring systems, Masood and Zalles (M and Z). Linear regression analyses were performed relating each score to interval from last pregnancy, stratified for parity, and adjusted for age. Results: Eighty-two patients had rFNA and cytologic analysis. The parous group’s (n=52) interval since last pregnancy was inversely correlated with the overall M score (p=0.034); pleomorphism and (p=0.047 and p=0.013 respectively). M score was also related to age at last pregnancy (p=0.026) as were pleomorphism and chromatin pattern (p=0.044 and 0.035 respectively). In the nulliparous group (n=30), there were no significant relationships between any of the cytological parameters or age. Conclusions: The CB of women with recent parity display specific cytological abnormalities that are related to risk of breast cancer, particularly HR negative breast cancer. This observation affords the opportunity to further evaluate rFNA as a tool for breast cancer risk assessment following pregnancy, and to identify molecular correlates of nuclear cytological abnormalities that may serve as targets for prevention of ER negative breast cancer.

False-positive and false-negative cases of fine-needle aspiration cytology for palpable breast lesions

Breast Cancer ◽  
2007 ◽  
Vol 14 (4) ◽  
pp. 388-392 ◽  
Author(s):  
Takashi Ishikawa ◽  
Yohei Hamaguchi ◽  
Mikiko Tanabe ◽  
Nobuyoshi Momiyama ◽  
Takashi Chishima ◽  
...  
Keyword(s):  
Fine Needle Aspiration ◽  
False Positive ◽  
Fine Needle Aspiration Cytology ◽  
False Negative ◽  
Needle Aspiration ◽  
Breast Lesions ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Palpable Breast ◽  
Needle Aspiration Cytology

scholarly journals A prospective study and correlation of cytological, cell-block and histopathological diagnosis of breast lesions

2021 ◽  
Vol 8 (3) ◽  
pp. 352-358
Author(s):  
Ankita Paul ◽  
Sowmya S Manjunath
Keyword(s):  
Prospective Study ◽  
Histopathological Examination ◽  
Needle Aspiration ◽  
Histopathological Diagnosis ◽  
Cell Block ◽  
Diagnostic Modality ◽  
Cross Sectional ◽  
Diagnostic Role ◽  
Palpable Breast ◽  
A Prospective Study

Breast carcinoma is the second most common cancer in the world and establishing an early diagnosis is clinically very important. Fine needle aspiration cytology (FNAC) is the fast, reliable and ideal initial diagnostic modality for the diagnosis of these lesions. This is a cross-sectional prospective study of 12 months duration. A total of 160 patients underwent FNAC of palpable breast lump/lumps. A cell-block preparation was done for 80 cases and the histopathological examination has been performed on all the 160 cases.The cytomorphological diagnosis, cell-block diagnosis and histopathological diagnosis were correlated using suitable statistical methods. Out of 160 patients, on cytological examination, 107 cases (67%) were benign and 53cases (33%) were malignant. On histopathological examination, 104 cases (65%) were benign and 56 cases (35%) were malignant. On examination of cell block, two cases which were indeterminate in FNAC turned out to be malignant. FNAC plays a main diagnostic role as an out-patient procedure which gives rapid diagnosis. FNAC when combined with cell-block can give more accurate diagnosis.

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