Development of Oral Controlled Release Tablet Formulations Based on Diltiazem–Carrageenan Complex

2004 ◽  
Vol 9 (2) ◽  
pp. 155-162 ◽  
Author(s):  
M. C. Bonferoni ◽  
S. Rossi ◽  
F. Ferrari ◽  
C. Caramella
Keyword(s):  
Controlled Release ◽  
Tablet Formulations ◽  
Release Tablet

scholarly journals Influence of Splitting on Dissolution Properties of Metoprolol Tablets

2009 ◽  
Vol 9 (3) ◽  
pp. 245-249 ◽  
Author(s):  
Edina Vranić ◽  
Alija Uzunović
Keyword(s):  
Controlled Release ◽  
Extended Release ◽  
Release Formulation ◽  
Extended Release Formulation ◽  
Dissolution Properties ◽  
Tablet Formulations ◽  
Score Line ◽  
Adequate Design ◽  
Release Tablet

The objective of this work was to compare several profiles of dissolution data for metoprolol controlled release tablet formulations in order to identify possible changes in dissolution profiles of whole and scored tablets. Adequate design of score lines (on one or both sides) as well as the technology of preparation of tablet mixtures ensure forming a score line of adequate thickness, shape, size, curvature. According to the obtained results, this type of extended release formulation is eligible for splitting and use in therapy either as a whole or scored tablets.

scholarly journals Formulation and Evaluation of Controlled-Release Tablet of Zolpidem Tartrate by Melt Granulation Technique

2011 ◽  
Vol 2011 ◽  
pp. 1-8
Author(s):  
Shailesh T. Prajapati ◽  
Amit N. Patel ◽  
Chhagan N. Patel
Keyword(s):  
Controlled Release ◽  
Independent Variables ◽  
Dependent Variables ◽  
Tablet Formulations ◽  
Binder Concentration ◽  
Full Factorial ◽  
Evaluation Parameters ◽  
Melt Granulation ◽  
Pvp K30 ◽  
Release Tablet

The present investigation describes the influence of the concentration of PEG 6000 as a melt binder and ratio of HPMC K4M : PVP on Zolpidem tartrate controlled-release tablet formulations using 32 full factorial design. The ratio of HPMC K4M and PVP K30 () and the concentration of melt binder () were selected as independent variables, and drug release at 1 hr (), 4 hr (), 8 hr (), diffusion coefficient (), and release rate constant () were selected as a dependent variable. Tablets were prepared by melt granulation technique and evaluated for various evaluation parameters. It was observed that concentration of melt binder had significant effect on , , , and Binder concentration 25% w/w was found optimum. Optimized formulation () showed good similarity with theoretical profile of drug. The variable had a significant effect on dependent variables, and the variable had no significant effect on dependent variables.

Effectiveness of Slow-Release Tablet Formulations of the IGR Diflubenzuron and the Bioinsecticide Spinosad Against Larvae ofAedes aegypti(L.)

2013 ◽  
Vol 21 (2) ◽  
pp. 349-353 ◽  
Author(s):  
M.S. Saleh ◽  
O.A. Abuzinadah ◽  
Kh.M. Al-Ghamdi ◽  
A.A. Alsagaf ◽  
J.A. Mahyoub
Keyword(s):  
Slow Release ◽  
Tablet Formulations ◽  
Release Tablet

An in Vivo Single- and Multiple-Dose Study of Several Marketed Brands of Conventional and Controlled-Release Theophylline

1984 ◽  
Vol 18 (2) ◽  
pp. 147-153 ◽  
Author(s):  
Jeffrey A. Kotzan ◽  
Joseph V. Vallner ◽  
James T. Stewart ◽  
Irwin L. Honigberg ◽  
W.J. Brown
Keyword(s):  
Single Dose ◽  
Controlled Release ◽  
Multiple Dose ◽  
Healthy Adult ◽  
Dosage Forms ◽  
Adult Males ◽  
Single Dose Study ◽  
Multiple Dose Study ◽  
Dose Study ◽  
Release Tablet

In a single-dose study, 18 healthy adult males consumed each of six dosage forms of theophylline. A conventional-release tablet, a syrup, and four competing brands of controlled-release theophylline were studied. Serial serum samples were obtained and analyzed via high pressure liquid chromatography (HPLC). After achieving steady state, 15 healthy adult males consumed each of five dosage forms of theophylline in a multiple-dose study. Serial blood samples were obtained between 0 and 72 hours and subjected to analysis with HPLC. The results indicated that the controlled-release products were not bioequivalent, although they achieved longer time-to-peak values than did the immediate-release syrup and the conventional-release tablet. A single sustained-release product was uniquely different on most pharmacokinetic parameters when compared with the remaining three controlled-release products. In general, the dosage form variation exceeded the individual subject variation on the single-dose study, but the opposite was true for the multiple-dose study.

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