CONTROLLED RELEASE TABLET FORMULATIONS OF ISOXSUPRINE HYDROCHLORIDE USING DIRECT COMPRESSION TECHNIQUE

The objective of this work was to compare several profiles of dissolution data for metoprolol controlled release tablet formulations in order to identify possible changes in dissolution profiles of whole and scored tablets. Adequate design of score lines (on one or both sides) as well as the technology of preparation of tablet mixtures ensure forming a score line of adequate thickness, shape, size, curvature. According to the obtained results, this type of extended release formulation is eligible for splitting and use in therapy either as a whole or scored tablets.

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Formulation and Evaluation of Controlled-Release Tablet of Zolpidem Tartrate by Melt Granulation Technique

ISRN Pharmaceutics ◽

10.5402/2011/208394 ◽

2011 ◽

Vol 2011 ◽

pp. 1-8

Author(s):

Shailesh T. Prajapati ◽

Amit N. Patel ◽

Chhagan N. Patel

Keyword(s):

Controlled Release ◽

Independent Variables ◽

Dependent Variables ◽

Tablet Formulations ◽

Binder Concentration ◽

Full Factorial ◽

Evaluation Parameters ◽

Melt Granulation ◽

Pvp K30 ◽

Release Tablet

The present investigation describes the influence of the concentration of PEG 6000 as a melt binder and ratio of HPMC K4M : PVP on Zolpidem tartrate controlled-release tablet formulations using 32 full factorial design. The ratio of HPMC K4M and PVP K30 () and the concentration of melt binder () were selected as independent variables, and drug release at 1 hr (), 4 hr (), 8 hr (), diffusion coefficient (), and release rate constant () were selected as a dependent variable. Tablets were prepared by melt granulation technique and evaluated for various evaluation parameters. It was observed that concentration of melt binder had significant effect on , , , and Binder concentration 25% w/w was found optimum. Optimized formulation () showed good similarity with theoretical profile of drug. The variable had a significant effect on dependent variables, and the variable had no significant effect on dependent variables.

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Development of Oral Controlled Release Tablet Formulations Based on Diltiazem–Carrageenan Complex

Pharmaceutical Development and Technology ◽

10.1081/pdt-120027428 ◽

2004 ◽

Vol 9 (2) ◽

pp. 155-162 ◽

Cited By ~ 28

Author(s):

M. C. Bonferoni ◽

S. Rossi ◽

F. Ferrari ◽

C. Caramella

Keyword(s):

Controlled Release ◽

Tablet Formulations ◽

Release Tablet

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FORMULATION AND EVALUATION OF GASTRORETENTIVE FLOATING BIOADHESIVE TABLETS OF HYDROCHLORTHIAZIDE

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2017.v10i5.17137 ◽

2017 ◽

Vol 10 (5) ◽

pp. 150

Author(s):

Ramu Bandameedi ◽

Shanmunga Pandiyan P

Keyword(s):

Drug Delivery ◽

Controlled Release ◽

Xanthan Gum ◽

Zero Order ◽

Direct Compression ◽

Compression Technique ◽

First Order ◽

Gastric Residence Time ◽

Weight Variation ◽

Kinetic Treatment

Objective: Floating bioadhesive tablets of hydrochlorothiazide were developed to prolong gastric residence time leading to an increase in drugbioavailability where here a combination of floating and bioadhesion mechanism is combined.Methods: Tablets are prepared by direct compression technique using polymers xanthan gum, carbopol 974 P, HPMC K15M, HPMC K100M, magnesiumStearate USP-NF (Avicel PH 102), microcrystalline cellulose Ph 102, Talc, and sodium bicarbonate.Results: Tablets were evaluated for their physical characteristics, namely, hardness, thickness, friability and weight variation, drug content, andfloating properties. The best formulation subjected for kinetic treatment, i.e., zero order, first order, peppas, Higuchi, and Hixon-crowel. The R valuesare 0.9366, 0.9364, 0.9680, 0.9974, and 0.9283, respectively.Conclusion: Optimized formulae F4 containing polymers HPMC K4M and CARBOPOL 974 P showed more bioadhesion with a controlled release over12 hrs. Therefore, formulation F4 identified as a successful formulation for the development of floating bioadhesive tablets.Keywords: Hydrochlorothiazide, Floating tablets, Gastroretentive drug delivery system.

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Development and evaluation of controlled release ibuprofen matrix tablets by direct compression technique

Pharmaceutical Development and Technology ◽

10.3109/10837450903460467 ◽

2010 ◽

Vol 16 (1) ◽

pp. 1-11 ◽

Cited By ~ 4

Author(s):

Nisha Patel ◽

Parshotam Madan ◽

Senshang Lin

Keyword(s):

Controlled Release ◽

Matrix Tablets ◽

Direct Compression ◽

Compression Technique

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Synthesis and Characterization of calcium Starch: A New Controlled Release Polymer for floating tablets of Losartan Potassium

Asian Journal of Pharmaceutical Research ◽

10.52711/2231-5691.2021.00039 ◽

2021 ◽

pp. 219-226

Author(s):

K. Naga Prathyusha ◽

B. Hemalatha ◽

K. Padmalatha

Keyword(s):

Controlled Release ◽

Potato Starch ◽

Oral Dosage ◽

Losartan Potassium ◽

Direct Compression ◽

Compression Technique ◽

Floating Tablets ◽

Floating Drug Delivery ◽

Floating Drug Delivery System

Losartan potassium is used to treat high blood pressure (hypertension). The present study was aimed to prepare a floating drug delivery system to design a controlled release oral dosage form of Losartan potassium. This helps to overcome the demerit of limited residence time of the drug in the gastrointestinal track and hence to increase the duration of release. Hence objective of the present study is to develop Losartan potassium floating tablets by direct compression method using calcium starch as release retarding polymer. The calcium starch was synthesized by gelatinizing potato starch in the presence of sodium hydroxide and cross linking by treatment with calcium chloride. The micromeritic properties studies indicated that calcium starch is a promising pharmaceutical excipient in tablets. Floating tablets of Losartan potassium was formulated by direct compression technique, using different concentration of calcium starch and compared with HPMC K-100 as release retard polymer. As the amount of calcium starch in the tablet increased, the drug release decreased. The formulation F5 containing 125 mg calcium starch showed better controlled release of 76.38% after 12 hours.

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