scholarly journals PERSISTENCE OF STREPTOCOCCAL GROUP A ANTIBODY IN PATIENTS WITH RHEUMATIC VALVULAR DISEASE

1968 ◽  
Vol 128 (5) ◽  
pp. 1081-1098 ◽  
Author(s):  
Burton A. Dudding ◽  
Elia M. Ayoub
Keyword(s):  
Rheumatic Fever ◽  
Antibody Level ◽  
Acute Illness ◽  
Valvular Disease ◽  
Acute Glomerulonephritis ◽  
Sydenham’S Chorea ◽  
Group A ◽  
Sydenham's Chorea ◽  
Antibody Levels ◽  
Rheumatic Valvular Disease

Antibody levels to streptococcal Group A and A-variant carbohydrates were determined using a radioactive immune precipitation technique on patients with rheumatic fever, with and without valvular disease, on patients with post-streptococcal acute glomerulonephritis, and on age-matched controls. During the acute phase of the above illness, the means of the antibody levels to both carbohydrate antigens were equally elevated and were significantly higher than the normal controls. When Group A antibody levels were determined on sera obtained at intervals of 5–12 months and 1–5 yr after the acute illness) it was found that the antibody levels declined within the normal range at the 5–12 month interval in patients with glomerulonephritis as well as in patients with rheumatic fever in whom no valvular involvement had complicated the disease, i.e., patients with pure Sydenham's chorea. However, in patients with rheumatic valvulitis, who had been on penicillin prophylaxis after the last acute episode, the A antibody level showed little decline from the level obtained during the acute illness. The elevated antibody level in patients with rheumatic valvulitis, including patients with Sydenham's chorea with valvulitis, persisted for periods of at least 1 yr and up to 20 yr after the last acute attack. The pattern of the decline of the antibody levels to the A-variant carbohydrate as well as of the antibody titers to the other streptococcal antigens tested, ASO and anti-DNase B, was similar in all patients studied regardless of the presence of valvular disease. These findings suggest that prolonged persistence of the Group A antibody is a phenomenon peculiar to patients with rheumatic valvular disease. Whether this persistence is involved in the pathogenesis or is an outcome of the valvular disease remains to be determined.

scholarly journals Acute Rheumatic Fever in a COVID-19-Positive Pediatric Patient

2021 ◽  
Vol 2021 ◽  
pp. 1-3
Author(s):  
Christa I. DeVette ◽  
Cherise S. Ali ◽  
Devon W. Hahn ◽  
Stephanie D. DeLeon
Keyword(s):  
Rheumatic Fever ◽  
Pediatric Patient ◽  
Acute Rheumatic Fever ◽  
Clinical Course ◽  
Developed Countries ◽  
Sydenham’S Chorea ◽  
Pediatric Populations ◽  
Sydenham's Chorea ◽  
Bacterial Coinfection

Bacterial coinfection and COVID-19 have been reported in pediatric populations. We describe a case of Sydenham’s chorea, which is exceedingly rare in developed countries, with concurrent COVID-19. Discussed here is the clinical course of an 8-year-old COVID-positive female with pure Sydenham’s chorea and subclinical carditis from acute rheumatic fever. To our knowledge, there are no documented reports of acute rheumatic fever in a pediatric patient with coexisting COVID-19 infection.

A PSYCHOSOMATIC STUDY OF EIGHT CHILDREN WITH SYDENHAM'S CHOREA

PEDIATRICS ◽  
1958 ◽  
Vol 21 (4) ◽  
pp. 582-595
Author(s):  
A. H. Chapman ◽  
Loraine Pilkey ◽  
Mary Jane Gibbons
Keyword(s):  
Rheumatic Fever ◽  
Emotional Stress ◽  
The Other ◽  
Personality Structure ◽  
Sydenham’S Chorea ◽  
Medical Study ◽  
Etiologic Agents ◽  
History Of ◽  
Sydenham's Chorea ◽  
Severe Personality Disorder

A psychosomatic study was made of eight children with Sydenham's chorea. The children ranged in age from 7 to 16 years. Three patients had a history of rheumatic fever and three had no evidence of rheumatic disease; in two patients the evidence for rheumatic fever was equivocal, one probably having had it and the other probably not. The eight children were found to be emotionally quite disturbed. Their personality structure was characterized by a triad of (a) marked passivity, (b) schizoid withdrawal from people, with two of the children being frankly schizophrenic, and (c) much underlying anxiety. Obsessive, phobic and depressive features were separately present in some of the children. In five cases the onset of Sydenham's chorea closely followed an episode of marked emotional stress, and in two others the correlation of chorea with emotional stress was equivocal. The literature was reviewed, and it was pointed out that in over half of all reported cases of Sydenham's chorea evidence of rheumatic fever could not be found. It is felt that Sydenham's chorea can be understood only as a psychosomatic illness potentially caused by a number of agents acting individually or jointly, and varying in their respective importance from case to case. Severe personality disorder and rheumatic fever are two such etiologic agents which may be operative in Sydenham's chorea. The importance of further psychosomatic study and experimental psychotherapy in the comprehensive medical study and management of children with this disorder is emphasized.

Migraine Headache in Patients with Sydenham's Chorea

Cephalalgia ◽  
2005 ◽  
Vol 25 (7) ◽  
pp. 542-544 ◽  
Author(s):  
AL Teixeira ◽  
FC Meira ◽  
DP Maia ◽  
MC Cunningham ◽  
F Cardoso
Keyword(s):  
Basal Ganglia ◽  
Rheumatic Fever ◽  
Essential Tremor ◽  
Migraine Headache ◽  
Neurological Symptoms ◽  
Tourette’S Syndrome ◽  
Sydenham’S Chorea ◽  
Sydenham's Chorea ◽  
Group 10 ◽  
Basal Ganglia Disorders

We compared the frequency of migraine among Sydenham's chorea (SC) patients, rheumatic fever (RF) patients without neurological symptoms and matched controls. Migraine was more frequent in SC patients (12/55, 21.8%) than in controls (9/110, 8.1%) and as common as in the RF group (10/55, 18.2%). Our data are in agreement with previous studies reporting higher frequency of migraine in other basal ganglia disorders, such as essential tremor and Tourette's syndrome.

A Rare Case of Chorea Gravidarum

2010 ◽  
Vol 2 (2) ◽  
pp. 145-146 ◽  
Author(s):  
Madhuri Gawande ◽  
Sunita Ghike ◽  
Sheela Jain
Keyword(s):  
Rheumatic Fever ◽  
Rare Case ◽  
Past History ◽  
Factors Associated ◽  
Sydenham’S Chorea ◽  
Generic Term ◽  
History Of ◽  
Sydenham's Chorea ◽  
Childhood Factors

ABSTRACT Chorea Gravidarum is the term given to chorea occurring during pregnancy. It is not an etiologically or pathologically distinct morbid entity but generic term for chorea of any etiology. We report a case of Chorea Gravidarum, who had past history of Rheumatic fever and Sydenham's Chorea in childhood. Factors associated with recurrence of chorea; those aggravating chorea during pregnancy and its management have been discussed.

scholarly journals Prevalence of Sydenham’s chorea in patients with Acute Rheumatic fever in Nepal

2013 ◽  
Vol 9 (1) ◽  
pp. 30-32 ◽  
Author(s):  
PR Regmi ◽  
A Shrestha ◽  
HH Khanal ◽  
BP Nepal ◽  
P Chapagain
Keyword(s):  
Rheumatic Fever ◽  
Acute Rheumatic Fever ◽  
Control Programme ◽  
Age Group ◽  
The Third ◽  
Male Ratio ◽  
Sydenham’S Chorea ◽  
Sydenham's Chorea ◽  
Common Manifestation ◽  
Heart Foundation

Background Sydenham’s Chorea (SC) is a major manifestation of acute rheumatic fever (ARF) and is the only evidence of ARF in approximately 20% of cases. There are no published reports on prevalence of SC in patients with ARF in Nepal. Objectives This retrospective study was done to find out the prevalence of SC in patients with ARF in Nepal. Methods Four years data of 672 patients with ARF from the RF/RHD registry of National RF/RHD prevention & control programme launched by Ministry of Health and Population & Nepal Heart Foundation in 32 hospitals throughout Nepal were analyzed. Results Prevalence of SC as a major manifestation of ARF in Nepalese patients was found to be 3.87%. Females were mostly affected with a female-to-male ratio of 3:1. Patients of age group 10-15 years were affected the most. SC was the third most common manifestation of ARF after Arthritis and Carditis. DOI: http://dx.doi.org/10.3126/njh.v9i1.8345 Nepalese Heart Journal Vol.9(1) 2012 pp.30-32

Sydenham's chorea: not gone but perhaps forgotten

2015 ◽  
Vol 100 (12) ◽  
pp. 1160-1162 ◽  
Author(s):  
Miranda Crealey ◽  
Nicholas M Allen ◽  
David Webb ◽  
Anthony Bouldin ◽  
Niamh Mc Sweeney ◽  
...  
Keyword(s):  
Head Injury ◽  
Rheumatic Fever ◽  
Clinical Presentation ◽  
Emotional Lability ◽  
Sydenham’S Chorea ◽  
Increasing Trend ◽  
Sydenham's Chorea ◽  
Psychogenic Illness

Sydenham's chorea (SC) is characterised by chorea, emotional lability and hypotonia. In this study, we investigated the incidence and clinical presentation of childhood SC in Ireland (years 2006–2014). Nineteen cases were diagnosed. Five patients had rheumatic fever. An increasing trend with an incidence of 0.23/100 000 is reported. As most referral diagnoses included psychogenic illness, head injury and stroke, modern physicians may not be aware of this age old illness. A review of the manifestations and diagnosis of SC is presented.

scholarly journals Acoustic analysis of prosody in Sydenham's chorea

2010 ◽  
Vol 68 (5) ◽  
pp. 744-748 ◽  
Author(s):  
Patrícia M Oliveira ◽  
Francisco Cardoso ◽  
Débora P Maia ◽  
Mauro César Q Cunningham ◽  
Antonio Lúcio Teixeira Jr ◽  
...  
Keyword(s):  
Basal Ganglia ◽  
Rheumatic Fever ◽  
Huntington's Disease ◽  
Fundamental Frequency ◽  
Wilson’S Disease ◽  
Acoustic Analysis ◽  
Sydenham’S Chorea ◽  
Range Difference ◽  
Sydenham's Chorea ◽  
Slow Speech

There are few studies of language and speech in patients with Sydenham's chorea (SC). We have done an acoustic analysis of fundamental frequency (F0), duration and intensity of declarative and interrogative sentences made by 20 SC patients, 20 patients with rheumatic fever (RF) without chorea, and compared them with 20 healthy age-matched controls (CO). Each group included 12 females. We found that there is no difference between the RF and CO groups in all studied parameters. Patients with SC, however, presented with a speech characterized by decreased F0 range (difference between minimum and maximum F0), shorter duration of sentences, and higher intensity of the first syllable of sentences. The findings were not influenced by the nature of the sentences (i.e. , declarative or interrogative), but for all variables they were significantly more severe in males than females. In conclusion, we have demonstrated that patients with acute SC have an impairment of modulation of F0 and longer duration of emission of sentences, resulting in a monotone and slow speech. This pattern is similar to what has been described in other basal ganglia illnesses, such as Parkinson's disease, Huntington's disease and Wilson's disease.

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