High levels of secretory IgA and free secretory component in the serum of rats with bile duct obstruction.

In the rat , ligation of the bile duct induces a rapid and progressive elevation of the IgA levels in serum. The increase is about 4-fold at 1 h, 15-fold at 1 day, and 30-fold at 1 wk after ligation. The additional IgA is of the secretory type. Free secretory component also appears in serum after bile duct obstruction; it does not continue to increase and occasionally disappears from serum after prolonged ligation. The increase in serum IgA levels is selective. These changes are totally reversible if the bile duct is reopened at 1 day after ligature. These findings confirm the role of the rat liver in the transfer of circulating IgA into the bile.

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The role of percutaneous transhepatic cholangiography and grey-scale ultrasound in the investigation and treatment of bile duct obstruction

British Journal of Surgery ◽

10.1002/bjs.1800700813 ◽

1983 ◽

Vol 70 (8) ◽

pp. 494-496 ◽

Cited By ~ 4

Author(s):

C. P. Gibbons ◽

G. J. Griffiths ◽

Anne Cormack

Keyword(s):

Bile Duct ◽

Percutaneous Transhepatic Cholangiography ◽

Bile Duct Obstruction ◽

Duct Obstruction ◽

Grey Scale

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Impaired synthesis of retinol-binding protein and transthyretin in rat liver with bile duct obstruction

Digestive Diseases and Sciences ◽

10.1007/bf02091549 ◽

1996 ◽

Vol 41 (5) ◽

pp. 1038-1042 ◽

Cited By ~ 2

Author(s):

Toru Imamine ◽

Masataka Okuno ◽

Hisataka Moriwaki ◽

Yoshihiro Shidoji ◽

Yasutoshi Muto ◽

...

Keyword(s):

Bile Duct ◽

Rat Liver ◽

Binding Protein ◽

Retinol Binding Protein ◽

Bile Duct Obstruction ◽

Duct Obstruction

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REGULATION OF THE IMMUNE RESPONSE: SUPPRESSIVE AND ENHANCING EFFECTS OF PASSIVELY ADMINISTERED ANTIBODY

Journal of Experimental Medicine ◽

10.1084/jem.133.5.987 ◽

1971 ◽

Vol 133 (5) ◽

pp. 987-1003 ◽

Cited By ~ 41

Author(s):

Carolyn S. Pincus ◽

Michael E. Lamm ◽

Victor Nussenzweig

Keyword(s):

Immune Response ◽

Antibody Formation ◽

Secretory Component ◽

Secretory Iga ◽

Antigenic Determinants ◽

Antibody Synthesis ◽

Serum Iga ◽

Iga Antibody ◽

Antigen Antibody

The ability of passively administered antibody to suppress the immune response against homologous antigenic determinants while concomitantly enhancing the response against other unrelated determinants of the same antigen molecule has been established in two distinct antigen-antibody systems: (a) guinea pig γ2-immunoglobulin + passive anti-F(ab')2 antibody, where suppression of anti-F(ab')2 antibody synthesis is accompanied by enhancement of the anti-Fc response; and (b) human secretory IgA + passive anti-serum IgA antibody, where suppression of antibody production against the α and L chains accompanies augmentation of the response to the secretory component. The mechanisms of the suppressive and enhancing effects are probably unrelated for the following reasons: (a) Enhancement of the response to certain determinants may be obtained without discernible suppression of the response to the homologous determinants; and (b) the F(ab')2 fragments of passive antibody can mediate immune suppression but were not observed to enhance the response against the unrelated determinants of the same antigen molecule. Also, the timing for achieving maximum suppression or enhancement of antibody formation is not the same; enhancement was obtained only at a later time. Both the enhancement and suppressive effects were obtained with the purified γG fraction of antisera. This finding rules out an exclusive role of γM antibody in the enhancement phenomenon.

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