The alpha-globin pseudogene on mouse chromosome 17 is closely linked to H-2.

DNA sequences homologous to adult alpha-globin genes are dispersed in the mouse. Two functional genes are tightly linked on chromosome 11. Pseudogenes have been assigned to chromosomes 15 and 17 by analysis of interspecies somatic cell hybrids. We have now further characterized the second of these pseudogenes, Hba-a4. The gene is highly polymorphic, with three forms occurring in a panel of 15 inbred strains and a fourth occurring in an inbred strain derived from M. m. molossinus. Analysis of Hba-a4 alleles in CXB, BXH, and AKXL recombinant inbred strains placed Hba-a4 6.60 +/- 3.14 cM centromeric to H-2. Analysis of congenic mouse strains confirmed the linkage and the gene order. Hba-a4 is the first mammalian dispersed pseudogene to be localized in a linkage map, and should provide a useful marker for the region of chromosome 17 proximal to H-2.

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Erbb is linked to the alpha-globin locus on mouse chromosome 11.

Molecular and Cellular Biology ◽

10.1128/mcb.5.7.1784 ◽

1985 ◽

Vol 5 (7) ◽

pp. 1784-1786 ◽

Cited By ~ 18

Author(s):

J Silver ◽

J B Whitney ◽

C Kozak ◽

G Hollis ◽

I Kirsch

Keyword(s):

Mouse Chromosome ◽

Human Gene ◽

Congenic Mouse ◽

Mouse Strains ◽

Somatic Cell Hybrids ◽

Chromosome 11 ◽

Homologous Sequences ◽

Alpha Globin ◽

Mouse Chromosome 11 ◽

Congenic Mouse Strains

A fragment of the human gene for c-erb-B was used to map homologous sequences in mice. Analysis of somatic cell hybrids and recombinant inbred and congenic mouse strains indicated that this gene, designated Erbb, is closely linked to the gene for alpha-globin on mouse chromosome 11. Several genes controlling hematopoietic differentiation map to mouse chromosome 11.

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Erbb is linked to the alpha-globin locus on mouse chromosome 11

Molecular and Cellular Biology ◽

10.1128/mcb.5.7.1784-1786.1985 ◽

1985 ◽

Vol 5 (7) ◽

pp. 1784-1786

Author(s):

J Silver ◽

J B Whitney ◽

C Kozak ◽

G Hollis ◽

I Kirsch

Keyword(s):

Mouse Chromosome ◽

Human Gene ◽

Congenic Mouse ◽

Mouse Strains ◽

Somatic Cell Hybrids ◽

Chromosome 11 ◽

Homologous Sequences ◽

Alpha Globin ◽

Mouse Chromosome 11 ◽

Congenic Mouse Strains

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Polymorphism of Unique Noncoding DNA Sequences in Wild and Laboratory Mice

Genetics ◽

10.1093/genetics/117.1.101 ◽

1987 ◽

Vol 117 (1) ◽

pp. 101-108

Author(s):

Felipe Figueroa ◽

Masanori Kasahara ◽

Herbert Tichy ◽

Esther Neufeld ◽

Uzi Ritte ◽

...

Keyword(s):

Dna Sequences ◽

Inbred Mouse ◽

Inbred Strains ◽

Chromosome 17 ◽

Mouse Strains ◽

Laboratory Mice ◽

Noncoding Dna ◽

Wild Mice ◽

Dna Library ◽

T Complex

ABSTRACT Two DNA probes, D17Tul and D17Tu2, were isolated from a genomic DNA library containing only two mouse chromosomes, one of which is chromosome 17, carrying the major histocompatibility complex (H-2), as well as the t complex genes. The D17Tul probe was mapped to the centromeric region of chromosome 17 and the D17Tu2 probe to the S region of the H-2 complex. Neither of the two probes appeared to detect any genes, but both contained unique, nonrepetitive sequences. Typing of DNA obtained from a large panel of mice revealed the presence of four D17Tul patterns in inbred mouse strains, one very common, one less common, and two present in one strain each. The two common patterns could not be detected in appreciable frequencies in the European wild mice tested (one of the two patterns was, however, found in Australian wild mice). Conversely, the patterns found frequently in European wild mice are absent in the laboratory mice. We therefore conclude that wild mice from the sampled regions of Europe could not have provided the ancestral stocks from which inbred strains were derived. Only one D17Tul pattern was found in all the populations of Mus musculus tested, while eight patterns were found in Mus domesticus, with virtually all the populations being polymorphic. We suggest that this difference reflects different modes in which the two species colonized Europe. The distribution of the D17Tu2 patterns in inbred strains correlates with the distribution of H-2 haplotypes.

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EVIDENCE THAT TWO LOCI PREDOMINANTLY DETERMINE THE DIFFERENCE IN SUSCEPTIBILITY TO THE HIGH PRESSURE NEUROLOGIC SYNDROME TYPE I SEIZURE IN MICE

Genetics ◽

10.1093/genetics/99.2.285 ◽

1981 ◽

Vol 99 (2) ◽

pp. 285-307

Author(s):

R D McCall ◽

D Frierson

Keyword(s):

High Pressure ◽

Inbred Mouse ◽

Inbred Strains ◽

Chromosome 17 ◽

Seizure Threshold ◽

Mouse Strains ◽

Compression Rate ◽

Type I ◽

Major Locus ◽

The Difference

ABSTRACT Most mammals tested, when exposed to increasing pressure in helium/oxygen atmospheres, exhibit progressive motor disturbances culminating in two, usually successive, well-differentiated convulsive seizures. The seizures are highly reproducible components of the constellation of events that collectively constitute the High Pressure Neurologic Syndrome (HPNS). In the present study, we present evidence that the mean difference in seizure threshold pressures of the first seizure to occur (HPNS Type I) between inbred mouse strains DBA/2J and C57BL/6J is predominantly determined (> 60%) by the expression of a major locus—possibly linked to the H-2 locus on chromosome 17—and a minor locus, probably unlinked. This outcome is derived from applications of the maximum likelihood modeling procedure of Elston and Stewart (1973) and Stewart and Elston (1973) to eleven models of genetic determinacy and tests (including breeding tests) of "preferred" models so derived using BXD recombinant inbred strains that show the following: The major locus exhibits conditional dominance characteristics depending upon compression rate and minor locus genotype. At a constant mean compression rate of 100 atm hr-1, the major locus manifests strong, though incomplete, dominance apparently independent of minor locus genotype. Its expression is, however, highly sensitive to compression rate, losing its dominance altogether at a linear rate of 1,000 atm hr-1. The major locus interacts with the weakly dominant and relatively compression-rate-insensitive minor locus to retain dominance at fast compression only when the dominant alleles of both loci are present. A principal finding of this study is that employing two compression rates permits fuller genetic characterization of murine high-pressure seizure susceptibility differences than could be achieved by use of a single compression rate.

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