scholarly journals Sequences and diversity of human T cell receptor beta chain variable region genes.

1986 ◽  
Vol 164 (3) ◽  
pp. 739-750 ◽  
Author(s):  
N Kimura ◽  
B Toyonaga ◽  
Y Yoshikai ◽  
F Triebel ◽  
P Debre ◽  
...  
Keyword(s):  
T Cell ◽  
Gene Segment ◽  
Variable Region ◽  
Cell Receptor ◽  
Beta Chain ◽  
Human T Cell ◽  
T Cell Receptor Beta ◽  
Variable Gene ◽  
Variable Region Genes ◽  
Beta Gene

The nucleotide sequences of 22 human T cell antigen receptor (TcR) beta chain variable region genes isolated from various T lymphocytes have been analyzed. Of the 19 variable gene segment (V beta)-containing sequences, 17 were unique. The V beta gene segments were grouped into 11 families. Comparisons were made with the data of Concannon et al. to unify the nomenclature. The data is consistent with a total V beta gene segment repertoire with a most probable value of 38 members and an upper bound of 104 members at the 95% confidence level. Southern blot data of germline DNA using selected TcR V beta cDNAs as probes support this estimate. The human repertoire is approximately three to four times greater than that reported for the mouse. Explanations for this discrepancy are proposed.

T-cell receptor beta-chain expression: dependence on relatively few variable region genes

Science ◽  
1985 ◽  
Vol 229 (4713) ◽  
pp. 566-570 ◽  
Author(s):  
M. Behlke ◽  
D. Spinella ◽  
H. Chou ◽  
W Sha ◽  
D. Hartl ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Variable Region ◽  
Cell Receptor ◽  
Beta Chain ◽  
T Cell Receptor Beta ◽  
Variable Region Genes ◽  
Receptor Beta

scholarly journals Expression of a murine polyclonal T cell receptor marker correlates with the use of specific members of the V beta 8 gene segment subfamily.

1987 ◽  
Vol 165 (1) ◽  
pp. 257-262 ◽  
Author(s):  
M A Behlke ◽  
T J Henkel ◽  
S J Anderson ◽  
N C Lan ◽  
L Hood ◽  
...  
Keyword(s):  
Gene Expression ◽  
T Cell ◽  
T Lymphocyte ◽  
Gene Segment ◽  
Variable Region ◽  
Cell Receptor ◽  
Differential Reactivity ◽  
Cell Clones ◽  
Variable Region Genes ◽  
Beta Gene

A series of murine T lymphocyte clones were examined for reactivity with the KJ16-133 and F23.1 mAbs. Clones that were KJ16-133+,F23.1+ and KJ16-133-,F23.1+ were identified, but no KJ16-133+,F23.1- clones were observed. Within our panel of clones, therefore, the KJ16-133 antibody identifies a subset of F23.1+ cells. All F23.1+ clones examined express members of the V beta 8 subfamily of beta chain variable region genes; clones expressing V beta 8.1 or V beta 8.2 reacted with both KJ16-133 and F23.1, while clones expressing V beta 8.3 reacted only with F23.1. Thus, the differential reactivity of the KJ16-133 and F23.1 antibodies with cloned T cells correlates with the V beta gene expression of each clone. Reactivity with these antibodies should therefore be of utility for predicting the V beta gene expression in some T cell clones.

scholarly journals Tandem linkage and unusual RNA splicing of the T-cell receptor beta-chain variable-region genes.

1987 ◽  
Vol 84 (7) ◽  
pp. 1992-1996 ◽  
Author(s):  
H. S. Chou ◽  
S. J. Anderson ◽  
M. C. Louie ◽  
S. A. Godambe ◽  
M. R. Pozzi ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Rna Splicing ◽  
Variable Region ◽  
Cell Receptor ◽  
Beta Chain ◽  
T Cell Receptor Beta ◽  
Variable Region Genes ◽  
Receptor Beta
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