Autoantibodies produced spontaneously by young 1pr mice carry transforming growth factor beta and suppress cytotoxic T lymphocyte responses.
1995 ◽
Vol 181
(5)
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pp. 1875-1880
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Keyword(s):
Tgf Beta
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Young MRL/MPJ-lpr (lpr) mice 8-12 wk old challenged with alloantigen had significantly lower specific cytolytic T lymphocyte (CTL) responses than control MRL/MPJ +/+ mice. Serum from lpr mice compared with serum from ++ or normal C3H mice powerfully suppressed CTL responses in mixed lymphocyte cultures (MLC); absorbing lpr serum on protein G, adding antibody against transforming growth factor beta (TGF-beta) to cultures or dissociating immunoglobulin G (IgG) and TGF-beta before additions to cultures prevented suppression. Apparently autoantibody, similar to IgG produced by normal mice in response to immunization, carries TGF-beta which suppresses CTL responses in vivo and in vitro.
1991 ◽
Vol 173
(5)
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pp. 1121-1132
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1991 ◽
Vol 174
(3)
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pp. 539-545
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1990 ◽
Vol 172
(6)
◽
pp. 1777-1784
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2006 ◽
Vol 74
(3)
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pp. 183-192
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1992 ◽
Vol 12
(4)
◽
pp. 1674-1679
1992 ◽
Vol 12
(4)
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pp. 1674-1679
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1989 ◽
Vol 109
(1)
◽
pp. 429-440
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