scholarly journals Resistance to Fas-mediated Apoptosis of Peripheral T Cells in Human T Lymphocyte Virus Type I (HTLV-I) Transgenic Mice with Autoimmune Arthropathy

1997 ◽  
Vol 186 (1) ◽  
pp. 57-64 ◽  
Author(s):  
Shuji Kishi ◽  
Shinobu Saijyo ◽  
Masaaki Arai ◽  
Shigeru Karasawa ◽  
Susumu Ueda ◽  
...  
Keyword(s):  
T Cells ◽  
Transgenic Mice ◽  
Virus Type ◽  
T Lymphocyte ◽  
Type I ◽  
Critical Function ◽  
Peripheral T Cells ◽  
High Incidence ◽  
Human T Lymphocyte ◽  
Induced Apoptosis

Transgenic mice carrying the env-pX region of human T lymphocyte virus type I (HTLV-I) develop autoimmune arthropathy in high incidence. Adopting the approach that Fas-mediated apoptosis has a critical function in the elimination of self-reactive T cells, we examined the involvement of this apoptosis in the induction of autoimmunity in HTLV-I transgenic mice. Splenic T cells derived from the transgenic mice were more resistant to apoptosis induced by anti-Fas mAb than those of the nontransgenic mice, whereas no appreciable difference in apoptosis was detected for thymocytes from either mouse's type. The resistance of transgenic T cells may be due to Tax coded in the pX region, since Tax mediates the inhibition of anti-Fas– induced apoptosis in mature T cell line, Jurkat. Among the transgenic mice, the extent of the resistance to Fas-mediated apoptosis was further enhanced in transgenic T cells with disease. These results suggest that the escape of self-reactive T cells from Fas-mediated apoptosis in the periphery, is critical for the development of autoimmune arthropathy in HTLV-I transgenic mice.

scholarly journals Increased Expression of Human T Lymphocyte Virus Type I (HTLV-I) Tax11-19 Peptide–Human Histocompatibility Leukocyte Antigen A*201 Complexes on CD4+ CD25+T Cells Detected by Peptide-specific, Major Histocompatibility Complex–restricted Antibodies in Patients with HTLV-I–associated Neurologic Disease

2004 ◽  
Vol 199 (10) ◽  
pp. 1367-1377 ◽  
Author(s):  
Yoshihisa Yamano ◽  
Cyril J. Cohen ◽  
Norihiro Takenouchi ◽  
Karen Yao ◽  
Utano Tomaru ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Virus Type ◽  
T Lymphocyte ◽  
Cd8 T Cells ◽  
Neurological Disease ◽  
T Cell Subsets ◽  
Type I ◽  
Leukocyte Antigen ◽  
Human T Lymphocyte

Human T lymphocyte virus type I (HTLV-I)–associated chronic inflammatory neurological disease (HTLV-I–associated myelopathy/tropical spastic paraparesis [HAM/TSP]) is suggested to be an immunopathologically mediated disorder characterized by large numbers of HTLV-I Tax–specific CD8+ T cells. The frequency of these cells in the peripheral blood and cerebrospinal fluid is proportional to the amount of HTLV-I proviral load and the levels of HTLV-I tax mRNA expression. As the stimulus for these virus-specific T cells are immunodominant peptide–human histocompatibility leukocyte antigen (HLA) complexes expressed on antigen-presenting cells, it was of interest to determine which cells express these complexes and at what frequency. However, until now, it has not been possible to identify and/or quantify these peptide–HLA complexes. Using a recently developed antibody that specifically recognizes Tax11-19 peptide–HLA-A*201 complexes, the level of Tax11-19–HLA-A*201 expression on T cells was demonstrated to be increased in HAM/TSP and correlated with HTLV-I proviral DNA load, HTLV-I tax mRNA load, and HTLV-I Tax–specific CD8+ T cell frequencies. Furthermore, CD4+ CD25+ T cells were demonstrated to be the major reservoir of HTLV-I provirus as well as Tax11-19 peptide–HLA-A*201 complexes. These results indicate that the increased detection and visualization of peptide–HLA complexes in HAM/TSP CD4+ CD25+ T cell subsets that are shown to stimulate and expand HTLV-I Tax–specific CD8+ T cells may play an important role in the pathogenesis of HTLV-I–associated neurological disease.

Human T-lymphocyte virus type I (HTLV-I)-induced myeloneuropathy in rats: Oligodendrocytes undergo apoptosis in the presence of HTLV-INote

Apmis ◽  
2000 ◽  
Vol 108 (6) ◽  
pp. 459-466 ◽  
Author(s):  
OSAMU OHYA ◽  
HITOSHI IKEDA ◽  
UTANO TOMARU ◽  
ISAO YAMASHITA ◽  
TAKEFUMI KASAI ◽  
...  
Keyword(s):  
Virus Type ◽  
T Lymphocyte ◽  
Type I ◽  
Human T Lymphocyte

A rat model for human T lymphocyte virus type I-associated myeloneuropathy

2000 ◽  
Vol 106 (1-2) ◽  
pp. 105-113 ◽  
Author(s):  
Xiuyun Jiang ◽  
Hitoshi Ikeda ◽  
Utano Tomaru ◽  
Keisuke Morita ◽  
Yuetsu Tanaka ◽  
...  
Keyword(s):  
Virus Type ◽  
T Lymphocyte ◽  
Rat Model ◽  
Type I ◽  
Human T Lymphocyte

Provirus Expansion and Deregulation of Apoptosis-Related Genes in the Spinal Cord of a Rat Model for Human T-Lymphocyte Virus Type I-Associated Myeloneuropathy

2003 ◽  
Vol 9 (5) ◽  
pp. 530-538 ◽  
Author(s):  
Utano Tomaru ◽  
Hitoshi Ikeda ◽  
Xiuyun Jiang ◽  
Osamu Ohya ◽  
Takashi Yoshiki
Keyword(s):  
Spinal Cord ◽  
Virus Type ◽  
T Lymphocyte ◽  
Rat Model ◽  
Type I ◽  
Human T Lymphocyte

scholarly journals A novel animal model of thymic tumour: Development of epithelial thymoma in transgenic rats carrying human T lymphocyte virus type I pX gene

2003 ◽  
Vol 83 (5) ◽  
pp. 247-256 ◽  
Author(s):  
Kazunori Kikuchi ◽  
Hitoshi Ikeda ◽  
Takahiro Tsuchikawa ◽  
Takahiro Tsuji ◽  
Satoshi Tanaka ◽  
...  
Keyword(s):  
Animal Model ◽  
Virus Type ◽  
T Lymphocyte ◽  
Type I ◽  
Transgenic Rats ◽  
Tumour Development ◽  
Thymic Tumour ◽  
Human T Lymphocyte

scholarly journals Abnormal in vitro proliferation and differentiation of T cell colony-forming cells in patients with tropical spastic paraparesis/human T lymphocyte virus type I (HTLV-I)-associated myeloencephalopathy and healthy HTLV-I carriers.

1993 ◽  
Vol 177 (3) ◽  
pp. 741-750 ◽  
Author(s):  
Y Lunardi-Iskandar ◽  
A Gessain ◽  
V H Lam ◽  
R C Gallo
Keyword(s):  
Growth Factors ◽  
T Cell ◽  
Virus Type ◽  
T Lymphocyte ◽  
Spastic Paraparesis ◽  
Type I ◽  
Proliferation And Differentiation ◽  
Human T Lymphocyte ◽  
Cell Colony

T cell colonies were generated from the peripheral blood mononuclear cells (PBMC) of 10 patients with tropical spastic paraparesis/human T lymphocyte virus type I (HTLV-I)-associated myeloencephalopathy (TSP/HAM), two healthy HTLV-I carriers, and 17 healthy HTLV-I-seronegative subjects. PBMC were cultured in methylcellulose in the absence of added growth factors (spontaneous T cell colonies), or in the presence of phorbol myristate acetate and interleukin 2 (induced T cell colonies). PBMC T cell colony-forming cells (T-CFC) from all TSP/HAM patients and HTLV-I carriers were able to grow in the absence of added growth factors and/or mitogenic stimulation. Pooled spontaneous and induced colonies were composed of cells bearing CD3+, CD4+, CD8+, and CD1+ antigens. Colonies from normal HTLV-I-seronegative subjects displayed mature cells bearing the CD3+, CD4+, CD8+, and CD1- surface phenotype. In addition, spontaneous and induced T cell colonies expressed HTLV-I antigens in 18-38% of the cells from TSP/HAM patients and HTLV-I carriers. These results demonstrate that HTLV-I infection is associated with an abnormal proliferation and differentiation of T cell progenitors in vitro and that the T-CFC from HTLV-I-seropositive individuals are infected, suggesting that T-CFC abnormalities may play a predominant role in the pathophysiology of HTLV-I.

scholarly journals Peripheral T Cells Become Sensitive to Glucocorticoid- and Stress-Induced Apoptosis in Transgenic Mice Overexpressing SRG3

2001 ◽  
Vol 167 (2) ◽  
pp. 805-810 ◽  
Author(s):  
Sunmi Han ◽  
Heonsik Choi ◽  
Myung-gon Ko ◽  
Young I. Choi ◽  
Dong H. Sohn ◽  
...  
Keyword(s):  
T Cells ◽  
Transgenic Mice ◽  
Peripheral T Cells ◽  
Induced Apoptosis
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