scholarly journals Promiscuous gene expression patterns in single medullary thymic epithelial cells argue for a stochastic mechanism

2008 ◽  
Vol 105 (2) ◽  
pp. 657-662 ◽  
Author(s):  
J. Derbinski ◽  
S. Pinto ◽  
S. Rosch ◽  
K. Hexel ◽  
B. Kyewski
Keyword(s):  
Gene Expression ◽  
Epithelial Cells ◽  
Expression Patterns ◽  
Thymic Epithelial Cells ◽  
Gene Expression Patterns ◽  
Medullary Thymic Epithelial Cells ◽  
Stochastic Mechanism ◽  
Promiscuous Gene Expression

scholarly journals Biologically indeterminate yet ordered promiscuous gene expression in single medullary thymic epithelial cells

2019 ◽  
Vol 39 (1) ◽  
Author(s):  
Fatima Dhalla ◽  
Jeanette Baran‐Gale ◽  
Stefano Maio ◽  
Lia Chappell ◽  
Georg A Holländer ◽  
...  
Keyword(s):  
Gene Expression ◽  
Epithelial Cells ◽  
Thymic Epithelial Cells ◽  
Medullary Thymic Epithelial Cells ◽  
Promiscuous Gene Expression

Evidence for a network transcriptional control of promiscuous gene expression in medullary thymic epithelial cells

2009 ◽  
Vol 46 (16) ◽  
pp. 3240-3244 ◽  
Author(s):  
Cláudia Macedo ◽  
Adriane F. Evangelista ◽  
Danielle A. Magalhães ◽  
Thaís A. Fornari ◽  
Leandra L. Linhares ◽  
...  
Keyword(s):  
Gene Expression ◽  
Epithelial Cells ◽  
Transcriptional Control ◽  
Thymic Epithelial Cells ◽  
Medullary Thymic Epithelial Cells ◽  
Promiscuous Gene Expression

scholarly journals Contrasting models of promiscuous gene expression by thymic epithelium

2005 ◽  
Vol 202 (1) ◽  
pp. 15-19 ◽  
Author(s):  
Geoffrey O. Gillard ◽  
Andrew G. Farr
Keyword(s):  
Gene Expression ◽  
Epithelial Cells ◽  
Broad Spectrum ◽  
Alternative Model ◽  
Thymic Epithelial Cells ◽  
Central Tolerance ◽  
Thymic Epithelium ◽  
Medullary Thymic Epithelial Cells ◽  
Promiscuous Gene Expression ◽  
Self Antigens

Medullary thymic epithelial cells (mTECs) express a broad spectrum of tissue- restricted self-antigens (TRAs), which are required for the development of central tolerance. A new study suggests that TRA expression is a specialized property of terminally differentiated mTECs. However, as discussed here, an alternative model—whereby TRA expression is regulated by conserved developmental programs active in developing mTECs—may be equally plausible.

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