scholarly journals Nfil3 is required for the development of all innate lymphoid cell subsets

2014 ◽  
Vol 211 (9) ◽  
pp. 1733-1740 ◽  
Author(s):  
Cyril Seillet ◽  
Lucille C. Rankin ◽  
Joanna R. Groom ◽  
Lisa A. Mielke ◽  
Julie Tellier ◽  
...  

Innate lymphoid cell (ILC) populations protect against infection and are essential for lymphoid tissue formation and tissue remodeling after damage. Nfil3 is implicated in the function of adaptive immune lineages and NK cell development, but it is not yet known if Nfil3 regulates other innate lymphoid lineages. Here, we identify that Nfil3 is essential for the development of Peyer’s patches and ILC2 and ILC3 subsets. Loss of Nfil3 selectively reduced Peyer’s patch formation and was accompanied by impaired recruitment and distribution of lymphocytes within the patches. ILC subsets exhibited high Nfil3 expression and genetic deletion of Nfil3 severely compromised the development of all subsets. Subsequently, Nfil3−/− mice were highly susceptible to disease when challenged with inflammatory or infectious agents. Thus, we demonstrate that Nfil3 is a key regulator of the development of ILC subsets essential for immune protection in the lung and gut.

2020 ◽  
Vol 205 (10) ◽  
pp. 2679-2693 ◽  
Author(s):  
Ansel P. Nalin ◽  
Jesse J. Kowalski ◽  
Alexander C. Sprague ◽  
Blaire K. Schumacher ◽  
Adam G. Gerhardt ◽  
...  

2020 ◽  
Vol 11 ◽  
Author(s):  
Vladislava Stokic-Trtica ◽  
Andreas Diefenbach ◽  
Christoph S. N. Klose

Immunity ◽  
2017 ◽  
Vol 46 (5) ◽  
pp. 818-834.e4 ◽  
Author(s):  
Masaki Miyazaki ◽  
Kazuko Miyazaki ◽  
Kenian Chen ◽  
Yi Jin ◽  
Jacob Turner ◽  
...  

Cell Reports ◽  
2020 ◽  
Vol 31 (11) ◽  
pp. 107771 ◽  
Author(s):  
Brock G. Bennion ◽  
Carys A. Croft ◽  
Teresa L. Ai ◽  
Wei Qian ◽  
Amber M. Menos ◽  
...  

Aging Cell ◽  
2019 ◽  
Vol 18 (6) ◽  
Author(s):  
Shanti S. D'Souza ◽  
Xiaofei Shen ◽  
Ivan T. H. Fung ◽  
Longyun Ye ◽  
Marcy Kuentzel ◽  
...  

2016 ◽  
Vol 17 (3) ◽  
pp. 269-276 ◽  
Author(s):  
Isabel E Ishizuka ◽  
Sylvestre Chea ◽  
Herman Gudjonson ◽  
Michael G Constantinides ◽  
Aaron R Dinner ◽  
...  

Immunity ◽  
2020 ◽  
Vol 52 (2) ◽  
pp. 275-294.e9 ◽  
Author(s):  
Katherine Oherle ◽  
Elizabeth Acker ◽  
Madeline Bonfield ◽  
Timothy Wang ◽  
Jerilyn Gray ◽  
...  

2017 ◽  
Vol 11 (1) ◽  
pp. 50-60 ◽  
Author(s):  
M L Robinette ◽  
M Cella ◽  
J B Telliez ◽  
T K Ulland ◽  
A D Barrow ◽  
...  

Immunity ◽  
2018 ◽  
Vol 49 (3) ◽  
pp. 464-476.e4 ◽  
Author(s):  
Luxi Chen ◽  
Youssef Youssef ◽  
Cameron Robinson ◽  
Gabrielle F. Ernst ◽  
Mary Y. Carson ◽  
...  

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