scholarly journals Deciphering cancer fibroblasts

2018 ◽  
Vol 215 (12) ◽  
pp. 2967-2968 ◽  
Author(s):  
Giulia Biffi ◽  
David A. Tuveson
Keyword(s):  
Breast Cancer ◽  
Bone Marrow ◽  
Tumor Growth ◽  
Functional Heterogeneity ◽  
Bone Marrow Derived Cells

In this issue of JEM, Raz et al. (https://doi.org/10.1084/jem.20180818) identify a subset of bone marrow–derived cells that uniquely promotes breast cancer angiogenesis and tumor growth. The existence of functional heterogeneity among stromal populations motivates further fundamental and therapeutic inquiries.

scholarly journals TMIC-16. THE IMMUNO-PROTECTIVE FUNCTION OF GLIOMA-ASSOCIATED BONE MARROW DERIVED CELLS DEPENDS ON THE STAGE OF TUMOR GROWTH AND IS INFLUENCED BY TREATMENT WITH MINOCYCLINE

2017 ◽  
Vol 19 (suppl_6) ◽  
pp. vi246-vi246
Author(s):  
Sheila Mansouri ◽  
Kelly Burrell ◽  
Mamatjan Yasin ◽  
Sameer Agnihotri ◽  
Romina Nejad ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Tumor Growth ◽  
Protective Function ◽  
Bone Marrow Derived Cells

scholarly journals Granulocyte-macrophage colony-stimulating factor increases tumor growth and angiogenesis directly by promoting endothelial cell function and indirectly by enhancing the mobilization and recruitment of proangiogenic granulocytes

Tumor Biology ◽  
2017 ◽  
Vol 39 (2) ◽  
pp. 101042831769223 ◽  
Author(s):  
Qiaowei Zheng ◽  
Xueqian Li ◽  
Xiaoliang Cheng ◽  
Ting Cui ◽  
Yingcheng Zhuo ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Tumor Growth ◽  
Cell Function ◽  
Colony Stimulating Factor ◽  
Endothelial Cell Function ◽  
Bone Marrow Derived Cells ◽  
Macrophage Colony Stimulating Factor ◽  
Macrophage Colony ◽  
Stimulating Factor

Granulocyte-macrophage colony-stimulating factor has been widely used as an adjuvant therapy for cancer patients exhibiting myelosuppression induced by chemotherapy or radiotherapy. However, the effects of granulocyte-macrophage colony-stimulating factor on tumor growth, as well as its precise mechanism, are still controversial due to inconsistent evidence. This study investigated the effect of exogenous granulocyte-macrophage colony-stimulating factor on the growth of B16 melanoma, S180 sarcoma, and U14 cervical carcinoma in mice. The angiogenesis and recruitment of bone-marrow-derived cells were analyzed in tumor tissues. Interactions among granulocyte-macrophage colony-stimulating factor, bone-marrow-derived cells, and B16 tumor cells were investigated in vitro. Proangiogenic types of bone-marrow-derived cells in blood were assessed both in vivo and in vitro. The results showed that granulocyte-macrophage colony-stimulating factor markedly facilitated the growth of B16 and S180 tumors, but not U14 tumors. Granulocyte-macrophage colony-stimulating factor increased the densities of blood vessels and the number of bone-marrow-derived cells in B16 tumor tissues. The granulocyte-macrophage colony-stimulating factor–induced enhancement of tumor cell proliferation was mediated by bone-marrow-derived cells in vitro. Meanwhile, a distinct synergistic effect on endothelial cell function between granulocyte-macrophage colony-stimulating factor and bone-marrow-derived cells was observed. After separating two types of bone-marrow-derived cells, granulocyte-macrophage colony-stimulating factor–induced enhancement of tumor growth and angiogenesis in vivo was mediated by proangiogenic cells in granulocytes, but not monocytes, with CD11b+, vascular endothelial growth factor receptor 2, and C-X-C chemokine receptor 4 granulocytes possibly involved. These data suggest that granulocyte-macrophage colony-stimulating factor contributes to the growth and angiogenesis of certain types of tumor, and these mechanisms are probably mediated by proangiogenic cells in granulocytes. Applying granulocyte-macrophage colony-stimulating factor may attenuate the antitumor effects of chemotherapy and radiotherapy in certain types of tumor.

mPGES-1-expressing bone marrow-derived cells enhance tumor growth and angiogenesis in mice

2010 ◽  
Vol 64 (6) ◽  
pp. 409-416 ◽  
Author(s):  
Hiroki Kamata ◽  
Kanako Hosono ◽  
Tatsunori Suzuki ◽  
Yasufumi Ogawa ◽  
Hidefumi Kubo ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Tumor Growth ◽  
Bone Marrow Derived Cells ◽  
Enhance Tumor Growth

scholarly journals EMMPRIN regulates tumor growth and metastasis by recruiting bone marrow-derived cells through paracrine signaling of SDF-1 and VEGF

Oncotarget ◽  
2015 ◽  
Vol 6 (32) ◽  
pp. 32575-32585 ◽  
Author(s):  
Yanke Chen ◽  
Xingchun Gou ◽  
Derek Kai Kong ◽  
Xiaofei Wang ◽  
Jianhui Wang ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Tumor Growth ◽  
Paracrine Signaling ◽  
Bone Marrow Derived Cells ◽  
Tumor Growth And Metastasis

scholarly journals Bone marrow–derived fibroblasts are a functionally distinct stromal cell population in breast cancer

2018 ◽  
Vol 215 (12) ◽  
pp. 3075-3093 ◽  
Author(s):  
Yael Raz ◽  
Noam Cohen ◽  
Ophir Shani ◽  
Rachel E. Bell ◽  
Sergey V. Novitskiy ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Bone Marrow ◽  
Stromal Cells ◽  
Lung Metastases ◽  
Breast Tumors ◽  
Patient Stratification ◽  
Breast Cancer Patients ◽  
Functional Heterogeneity ◽  
Distinct Subpopulation ◽  
Worse Prognosis

Cancer-associated fibroblasts (CAFs) are highly prominent in breast tumors, but their functional heterogeneity and origin are still largely unresolved. We report that bone marrow (BM)–derived mesenchymal stromal cells (MSCs) are recruited to primary breast tumors and to lung metastases and differentiate to a distinct subpopulation of CAFs. We show that BM-derived CAFs are functionally important for tumor growth and enhance angiogenesis via up-regulation of Clusterin. Using newly generated transgenic mice and adoptive BM transplantations, we demonstrate that BM-derived fibroblasts are a substantial source of CAFs in the tumor microenvironment. Unlike resident CAFs, BM-derived CAFs do not express PDGFRα, and their recruitment resulted in a decrease in the percentage of PDGFRα-expressing CAFs. Strikingly, decrease in PDGFRα in breast cancer patients was associated with worse prognosis, suggesting that BM-derived CAFs may have deleterious effects on survival. Therefore, PDGFRα expression distinguishes two functionally unique CAF populations in breast tumors and metastases and may have important implications for patient stratification and precision therapeutics.

scholarly journals Bone marrow-derived cells are implicated as a source of lymphatic endothelial progenitors in human breast cancer

2014 ◽  
Vol 3 (6) ◽  
pp. e29080 ◽  
Author(s):  
Eveline Faes van’t Hull ◽  
Sylvian Bron ◽  
Luc Henry ◽  
Assia Ifticene-Treboux ◽  
Riccardo Turrini ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Bone Marrow ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Endothelial Progenitors ◽  
Bone Marrow Derived Cells
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