scholarly journals STUDIES ON THE AGENT OF INFECTIOUS HEPATITIS

1950 ◽  
Vol 92 (3) ◽  
pp. 283-297 ◽  
Author(s):  
Miles E. Drake ◽  
Albert W. Kitts ◽  
Mercer C. Blanchard ◽  
John D. Farquhar ◽  
Joseph Stokes ◽  
...  
Keyword(s):  
Hepatitis Virus ◽  
Short Interval ◽  
Well Being ◽  
Liver Function Tests ◽  
Infectious Hepatitis ◽  
Amniotic Cavity ◽  
Hen’S Egg ◽  
Secondary Stage ◽  
Embryo Tissue ◽  
Natural Virus

The successful cultivation of the virus of infectious hepatitis in chick embryo tissue culture and in the amniotic cavity of the embryonated hen's egg is supported by a comparison of the disease induced in volunteers by the cultivated virus with hepatitis without jaundice resulting from experimental infection with natural infectious hepatitis virus. Both types of viral preparations produced illnesses in comparable percentages of volunteers (83 and 75 per cent, respectively) after similar average periods of incubation (24.4 and 23.4 days, respectively) and of similar average duration (28.3 and 27.6 days, respectively). The disease could be divided in both groups of patients into a primary stage, followed after a short interval of relative well being by the secondary stage. The illnesses in both instances were characterized by anorexia, nausea, vomiting, enlarged, tender livers and abnormal liver function tests, and frequently temperature elevations. They differed in that jaundice was observed in 31 per cent of the cases resulting from infection with natural virus but not in any patients infected with the cultivated virus.

COMPARISON OF ACTIVITIES OF ISOCITRIC DEHYDROGENASE AND GLUTAMIC-OXALACETIC TRANSAMINASE IN SERUM IN INFECTIOUS HEPATITIS

PEDIATRICS ◽  
1960 ◽  
Vol 25 (5) ◽  
pp. 807-811
Author(s):  
Oscar Bodansky ◽  
Morton K. Schwartz ◽  
Saul Krugman ◽  
Joan P. Giles ◽  
A. Milton Jacobs
Keyword(s):  
Clinical Evidence ◽  
Hepatitis Virus ◽  
Infectious Hepatitis ◽  
Glutamic Oxalacetic Transaminase ◽  
Isocitric Dehydrogenase

Activities of isocitric dehydrogenase (ICD) and glutamic-oxalacetic transaminase (GOT) in serum were determined concurrently and sequentially in 42 patients exposed to hepatitis virus. In nine patients who developed clear clinical evidence of the disease, the maximal values for both enzymes were attained on the same day, but the relative rise in GOT was substantially greater. Considerations are presented for the preferential use of the latter enzyme as an aid in diagnosis of hepatitis.

Demonstration of Infectious Hepatitis Virus in Presymptomatic Period after Transfer by Transfusion.*

1946 ◽  
Vol 61 (3) ◽  
pp. 276-280 ◽  
Author(s):  
F. Thomas ◽  
A. W. Frisch ◽  
J. J. Quilligan
Keyword(s):  
Hepatitis Virus ◽  
Infectious Hepatitis

VIII.—Clinical Uses of Immunoglobulin

1972 ◽  
Vol 71 (S1) ◽  
pp. s73-s82
Author(s):  
J. A. Gray
Keyword(s):  
Hepatitis Virus ◽  
Immunoglobulin A ◽  
Infectious Hepatitis ◽  
Smallpox Vaccination ◽  
Passive Immunisation ◽  
Active Immunisation ◽  
Haemolytic Disease ◽  
The Public ◽  
Hepatitis Virus B ◽  
Human Specific

SynopsisAlthough active immunisation against infection tends to diminish the usefulness of immunoglobulin a return to passive immunisation may well occur because of the public apathy regarding childhood immunisation schedules, the development of antibiotic resistance and the expanding proportion of patients who are infection prone because of immunosuppression. An assessment of the usefulness and likely demand for immunoglobulin is urgently needed. It does not transmit infection and it is generally free of side-effects when a single dose is injected. Human normal immunoglobulin prevents infectious hepatitis (virus A) and measles and is valuable for hypogammaglobulinaemic patients. Limited supplies of human specific immunoglobulins are available and effective in preventing Rhesushaemolytic disease, in treating the complications of smallpox vaccination, and for tetanus prophylaxis. Hyperimmune material may also become available for the prevention of serum hepatitis (virus B), chickenpox and the rubella syndrome. Problems of administration and supply could prove difficult to overcome. The principles involved in preventing Rhesus-haemolytic disease with immunoglobulin could possibly be applied in the management of auto-immune disease at some future date.

Liver-function Tests in Infectious Hepatitis

BMJ ◽  
1966 ◽  
Vol 2 (5527) ◽  
pp. 1451-1451 ◽  
Author(s):  
J. R. Hobbs
Keyword(s):  
Liver Function ◽  
Liver Function Tests ◽  
Infectious Hepatitis ◽  
Function Tests

scholarly journals PSYCHIC STRESS IN C HEPATITIS VIRUS INFECTION

2016 ◽  
Vol 63 (4) ◽  
pp. 286-290
Author(s):  
Camelia Patrascu Boanca ◽  
◽  
Mihaela Minulescu ◽  
George Gherlan ◽  
Petre Iacob Calistru ◽  
...  
Keyword(s):  
Hepatitis Virus ◽  
Geographical Area ◽  
Local Environment ◽  
Well Being ◽  
Emotional Reaction ◽  
Emotional Reactions ◽  
Virus Hepatitis ◽  
Psychological Reactions ◽  
Related Quality ◽  
Chronic Hcv

The purpose of this review is to examine if the psychic stress can operate as a co-factor in the pathogenesis of the infection with C virus hepatitis. C virus hepatitis agents represent a common environmental stressor and the human body reaction to the stressor can be regarded as a stress too. Patients have experienced and reported various emotional reactions after being diagnosed with chronic HCV. The intensity of emotional reaction varies from one patient to another, and has been differently experienced and reported. The vast majority of patients experience a decreased health related quality of life (HRQOL). The most common psychological reactions are fatigue, depression, fear, anxiety, anger, negative self esteem, stigma and sadness. Depression appears to be present in those with HCV infection in a higher percentage than it is in the general population. On many instances, the emotional reactions appear to be influenced by the level of education, geographical area, cultural background, awareness of the disease, gender, age, local environment and culture, wealth, time of diagnose and treatment. Various studies and researches lead us to believe that an improvement in depressive symptoms lead to an improvement in fatigue and well being.

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