Correlations Between Cytomegalovirus Infection and Cutaneous-Mucosal Manifestations of Immune Thrombocytopenic Purpura

Immune thrombocytopenic purpura is a pathological condition in which the decrease in the number of circulating platelets outlines a polymorphic picture. It takes the form of a haemorrhagic syndrome at the facial and mucosal level, manifesting usually through epistaxis, gingivorrhagia, bruising, petechial purpura. Mechanisms of disease onset and symptomatology are not fully known, yet many studies concluded that infectious factors and immunological disorders are involved in the etiopathogenesis of immune thrombocytopenic purpura. Infectious diseases with a possible etiological role in triggering a secondary thrombocytopenic syndrome are predominantly viral: hepatitis virus (B, C) infection, HIV infection, infectious mononucleosis or Cytomegalovirus infection. This paper aims to highlight the involvement of Cytomegalovirus infection in the occurrence of antithrombotic antibodies and haemorrhagic manifestations of immune thrombocytopenic purpura. Determination of the anti-Cytomegalovirus viral serology was performed using the immunochemical method of electrochemiluminescence detection (ECLIA).