scholarly journals Heterosubtypic Immunity to Influenza A Virus Infection Requires B Cells but Not CD8+Cytotoxic T Lymphocytes

2001 ◽  
Vol 183 (3) ◽  
pp. 368-376 ◽  
Author(s):  
Huan H. Nguyen ◽  
Frederik W. van Ginkel ◽  
Huong L. Vu ◽  
Jerry R. McGhee ◽  
Jiri Mestecky
Keyword(s):  
B Cells ◽  
T Lymphocytes ◽  
Virus Infection ◽  
Influenza A Virus ◽  
Cytotoxic T Lymphocytes ◽  
Influenza A ◽  
Heterosubtypic Immunity ◽  
Influenza A Virus Infection

scholarly journals CD83 Expression Regulates Antibody Production in Response to Influenza A Virus Infection

2020 ◽  
Author(s):  
Madhav Akauliya ◽  
Avishekh Gautam ◽  
Sony Maharjan ◽  
Byoung Kwon Park ◽  
Jinsoo Kim ◽  
...  
Keyword(s):  
Bone Marrow ◽  
B Cells ◽  
Virus Infection ◽  
Influenza A Virus ◽  
Cell Population ◽  
Peritoneal Cavity ◽  
Antibody Production ◽  
Influenza A ◽  
Wild Type ◽  
Influenza A Virus Infection

Abstract Background: CD83 is known to regulate lymphocyte maturation, activation, homeostasis, and antibody response to immunization and infection. While CD83 has a major part in B cell function, its role in influenza A virus infection has not yet been investigated. Methods: We investigated the role of CD83 using C57BL/6J wild type mice and CD83 knockout (KO) mice after intraperitoneal administration of the influenza A/WSN/1933 virus. We analyzed cells of the peritoneal cavity, splenocytes, and cells of the bone marrow with FACS to investigate CD83 expression and cell population change in response to the virus infection. ELISA was performed with sera and peritoneal cavity fluids to detect A/WSN/1933 virus-specific IgG and the subclasses of IgG. Results: FACS analysis data showed a transient but distinct induction of CD83 expression in the peritoneal B cells of wild type mice. CD83 KO mice exhibited a delayed recovery of B cells in the bone marrow after influenza virus infection and overall, a smaller T cell population compared to wild type mice. The peritoneal cavity and serum of the wild type mice contained a high titer of IgG within 14 days after infection, whereas the CD83 KO mice had a very low titer of IgG. Conclusions: These results show the importance of CD83 in lymphocytes homeostasis and antibody production during influenza A virus infection.

Mechanism of heterosubtypic immunity to influenza A virus infection

2001 ◽  
Vol 1219 ◽  
pp. 333-340 ◽  
Author(s):  
Huan H Nguyen ◽  
Frederik W van Ginkel ◽  
Huong L Vu ◽  
Jerry R McGhee ◽  
Jiri Mestecky
Keyword(s):  
Virus Infection ◽  
Influenza A Virus ◽  
Influenza A ◽  
Heterosubtypic Immunity ◽  
Influenza A Virus Infection

scholarly journals Heterosubtypic Immunity to Lethal Influenza A Virus Infection Is Associated with Virus-Specific CD8+Cytotoxic T Lymphocyte Responses Induced in Mucosa-Associated Tissues

Virology ◽  
1999 ◽  
Vol 254 (1) ◽  
pp. 50-60 ◽  
Author(s):  
Huan H. Nguyen ◽  
Zina Moldoveanu ◽  
Miroslav J. Novak ◽  
Frederik W. van Ginkel ◽  
Elisabeth Ban ◽  
...  
Keyword(s):  
Virus Infection ◽  
Influenza A Virus ◽  
T Lymphocyte ◽  
Influenza A ◽  
Cytotoxic T Lymphocyte ◽  
Heterosubtypic Immunity ◽  
Influenza A Virus Infection ◽  
Lymphocyte Responses

scholarly journals Induction of Virus-Specific Cytotoxic T Lymphocytes as a Basis for the Development of Broadly Protective Influenza Vaccines

2011 ◽  
Vol 2011 ◽  
pp. 1-12 ◽  
Author(s):  
Marine L. B. Hillaire ◽  
Albert D. M. E. Osterhaus ◽  
Guus F. Rimmelzwaan
Keyword(s):  
T Lymphocytes ◽  
Influenza A Virus ◽  
Cytotoxic T Lymphocytes ◽  
Influenza A ◽  
Influenza Viruses ◽  
Antigenic Drift ◽  
Influenza Vaccines ◽  
Virus Infections ◽  
Influenza A Viruses ◽  
Heterosubtypic Immunity

There is considerable interest in the development of broadly protective influenza vaccines because of the continuous emergence of antigenic drift variants of seasonal influenza viruses and the threat posed by the emergence of antigenically distinct pandemic influenza viruses. It has been recognized more than three decades ago that influenza A virus-specific cytotoxic T lymphocytes recognize epitopes located in the relatively conserved proteins like the nucleoprotein and that they cross-react with various subtypes of influenza A viruses. This implies that these CD8+T lymphocytes may contribute to protective heterosubtypic immunity induced by antecedent influenza A virus infections. In the present paper, we review the evidence for the role of virus-specific CD8+T lymphocytes in protective immunity against influenza virus infections and discuss vaccination strategies that aim at the induction of cross-reactive virus-specific T-cell responses.

scholarly journals CD83 expression regulates antibody production in response to influenza A virus infection

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
Madhav Akauliya ◽  
Avishekh Gautam ◽  
Sony Maharjan ◽  
Byoung Kwon Park ◽  
Jinsoo Kim ◽  
...  
Keyword(s):  
Bone Marrow ◽  
B Cells ◽  
Virus Infection ◽  
Influenza A Virus ◽  
Cell Population ◽  
Peritoneal Cavity ◽  
Antibody Production ◽  
Influenza A ◽  
Wild Type ◽  
Influenza A Virus Infection

Abstract Background CD83 is known to regulate lymphocyte maturation, activation, homeostasis, and antibody response to immunization and infection. While CD83 has a major part in B cell function, its role in influenza A virus infection has not yet been investigated. Methods We investigated the role of CD83 using C57BL/6J wild type mice and CD83 knockout (KO) mice after intraperitoneal administration of the influenza A/WSN/1933 virus. We analyzed cells of the peritoneal cavity, splenocytes, and cells of the bone marrow with FACS to investigate CD83 expression and cell population change in response to the virus infection. ELISA was performed with sera and peritoneal cavity fluids to detect A/WSN/1933 virus-specific IgG and the subclasses of IgG. Results FACS analysis data showed a transient but distinct induction of CD83 expression in the peritoneal B cells of wild type mice. CD83 KO mice exhibited a delayed recovery of B cells in the bone marrow after influenza virus infection and overall, a smaller T cell population compared to wild type mice. The peritoneal cavity and serum of the wild type mice contained a high titer of IgG within 14 days after infection, whereas the CD83 KO mice had a very low titer of IgG. Conclusions These results show the importance of CD83 in lymphocytes homeostasis and antibody production during influenza A virus infection.

scholarly journals Interleukin-22 Is Produced by Invariant Natural Killer T Lymphocytes during Influenza A Virus Infection

2012 ◽  
Vol 287 (12) ◽  
pp. 8816-8829 ◽  
Author(s):  
Christophe Paget ◽  
Stoyan Ivanov ◽  
Josette Fontaine ◽  
Joelle Renneson ◽  
Fany Blanc ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Virus Infection ◽  
Natural Killer ◽  
Influenza A Virus ◽  
Influenza A ◽  
Interleukin 22 ◽  
Influenza A Virus Infection ◽  
Invariant Natural Killer ◽  
Natural Killer T

scholarly journals Gamma Interferon Is Not Required for Mucosal Cytotoxic T-Lymphocyte Responses or Heterosubtypic Immunity to Influenza A Virus Infection in Mice

2000 ◽  
Vol 74 (12) ◽  
pp. 5495-5501 ◽  
Author(s):  
Huan H. Nguyen ◽  
Frederik W. van Ginkel ◽  
Huong L. Vu ◽  
Miroslav J. Novak ◽  
Jerry R. McGhee ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
Influenza A Virus ◽  
Influenza A ◽  
Gamma Interferon ◽  
Necrosis Factor Alpha ◽  
Virus Challenge ◽  
Heterosubtypic Immunity ◽  
Ifn Γ ◽  
Influenza A Virus Infection

ABSTRACT Heterosubtypic immunity (HSI) is defined as cross-protection against influenza virus of a different serotype than the virus initially encountered and is thought to be mediated by influenza virus-specific cytotoxic T lymphocytes (CTL). Since gamma interferon (IFN-γ) stimulates cytotoxic cells, including antigen-specific CTL which may control virus replication by secretion of antiviral cytokines such as tumor necrosis factor alpha and IFN-γ, we have investigated the mechanism of HSI by analyzing the role of IFN-γ for HSI in IFN-γ gene-deleted (IFN-γ−/−) mice. It has been reported that IFN-γ is not required for recovery from primary infection with influenza virus but is important for HSI. Here, we conclusively show that IFN-γ is not required for induction of secondary influenza virus-specific CTL responses in mediastinal lymph nodes and HSI to lethal influenza A virus infection. Although T helper 2 (Th2)-type cytokines were upregulated in the lungs of IFN-γ−/− mice after virus challenge, either Th1- or Th2-biased responses could provide heterosubtypic protection. Furthermore, titers of serum-neutralizing and cross-reactive antibodies to conserved nucleoprotein in IFN-γ−/− mice did not differ significantly from those in immunocompetent mice. These results indicate that lack of IFN-γ does not impair cross-reactive virus-specific immune responses and HSI to lethal infection with influenza virus. Our findings provide new insight for the mechanisms of HSI and should be valuable in the development of protective mucosal vaccines against variant virus strains, such as influenza and human immunodeficiency virus.

scholarly journals CD83 expression regulates antibody production in response to influenza A virus infection

2020 ◽  
Author(s):  
Madhav Akauliya ◽  
Avishekh Gautam ◽  
Sony Maharjan ◽  
Byoung Kwon Park ◽  
Jinsoo Kim ◽  
...  
Keyword(s):  
Bone Marrow ◽  
B Cells ◽  
Virus Infection ◽  
Influenza A Virus ◽  
Cell Population ◽  
Peritoneal Cavity ◽  
Antibody Production ◽  
Influenza A ◽  
Wild Type ◽  
Influenza A Virus Infection

Abstract Background: CD83 is known to regulate lymphocyte maturation, activation, homeostasis, and antibody response to immunization and infection. While CD83 has a major part in B cell function, its role in influenza A virus infection has not yet been investigated. Methods: We investigated the role of CD83 using C57BL/6J wild type mice and CD83 knockout (KO) mice after intraperitoneal administration of the influenza A/WSN/1933 virus. We analyzed cells of the peritoneal cavity, splenocytes, and cells of the bone marrow with FACS to investigate CD83 expression and cell population change in response to the virus infection. ELISA was performed with sera and peritoneal cavity fluids to detect A/WSN/1933 virus-specific IgG and the subclasses of IgG. Results: FACS analysis data showed a transient but distinct induction of CD83 expression in the peritoneal B cells of wild type mice. CD83 KO mice exhibited a delayed recovery of B cells in the bone marrow after influenza virus infection and overall, a smaller T cell population compared to wild type mice. The peritoneal cavity and serum of the wild type mice contained a high titer of IgG within 14 days after infection, whereas the CD83 KO mice had a very low titer of IgG. Conclusions: These results show the importance of CD83 in lymphocytes homeostasis and antibody production during influenza A virus infection.

Intranasal immunization with formalin-inactivated virus vaccine induces a broad spectrum of heterosubtypic immunity against influenza A virus infection in mice

Vaccine ◽  
2003 ◽  
Vol 21 (23) ◽  
pp. 3212-3218 ◽  
Author(s):  
Ayato Takada ◽  
Sachiko Matsushita ◽  
Ai Ninomiya ◽  
Yoshihiro Kawaoka ◽  
Hiroshi Kida
Keyword(s):  
Virus Infection ◽  
Influenza A Virus ◽  
Virus Vaccine ◽  
Broad Spectrum ◽  
Influenza A ◽  
Intranasal Immunization ◽  
Heterosubtypic Immunity ◽  
Influenza A Virus Infection
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