Synthetic Hybrids of Agropyron caespitosum x Agropyron dasystachyum and Sitanion hystrix

1968 ◽  
Vol 129 (4) ◽  
pp. 316-322 ◽  
Author(s):  
Douglas R. Dewey
Keyword(s):  
Synthetic Hybrids ◽  
Sitanion Hystrix

Synthetic Hybrids of Agropyron dasystachyum x Elymus glaucus and Sitanion hystrix

1968 ◽  
Vol 129 (4) ◽  
pp. 309-315 ◽  
Author(s):  
Douglas R. Dewey
Keyword(s):  
Synthetic Hybrids ◽  
Sitanion Hystrix ◽  
Elymus Glaucus

Synthetic Hybrids of Elymus canadensis x Sitanion hystrix

1967 ◽  
Vol 128 (1) ◽  
pp. 11-16 ◽  
Author(s):  
Douglas R. Dewey
Keyword(s):  
Synthetic Hybrids ◽  
Elymus Canadensis ◽  
Sitanion Hystrix

Natural and Synthetic Hybrids of Agropyron spicatum x Sitanion hystrix

1964 ◽  
Vol 91 (5) ◽  
pp. 396 ◽  
Author(s):  
Douglas R. Dewey
Keyword(s):  
Synthetic Hybrids ◽  
Sitanion Hystrix ◽  
Agropyron Spicatum ◽  
Natural And Synthetic

SYNTHETIC HYBRIDS OF HORDEUM BOGDANII WITH ELYMUS CANADENSIS AND SITANION HYSTRIX

1971 ◽  
Vol 58 (10) ◽  
pp. 902-908 ◽  
Author(s):  
Douglas R. Dewey
Keyword(s):  
Synthetic Hybrids ◽  
Elymus Canadensis ◽  
Sitanion Hystrix

scholarly journals Computational approach towards the design of artemisinin–thymoquinone hybrids against main protease of SARS-COV-2

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Victor Moreira de Oliveira ◽  
Matheus Nunes da Rocha ◽  
Emanuel Paula Magalhães ◽  
Francisco Rogênio da Silva Mendes ◽  
Márcia Machado Marinho ◽  
...  
Keyword(s):  
Enzyme Inhibitors ◽  
Antiviral Treatment ◽  
Docking Studies ◽  
Hybrid Products ◽  
Main Protease ◽  
The Central Nervous System ◽  
Synthetic Hybrids ◽  
Energy Of Interaction ◽  
Relevant Interaction ◽  
High Absorption

Abstract Background The sanitary emergency installed in the world, generated by the pandemic of COVID-19, instigates the search for scientific strategies to mitigate the damage caused by the disease to different sectors of society. The disease caused by the coronavirus, SARS-CoV-2, reached 216 countries/territories, where about 199 million people were reported with the infection. Of these, more than 4 million died. In this sense, strategies involving the development of new antiviral molecules are extremely important. The main protease (Mpro) from SARS-CoV-2 is an important target, which has been widely studied for antiviral treatment. This work aims to perform a screening of pharmacodynamics and pharmacokinetics of synthetic hybrids from thymoquinone and artemisin (THY-ART) against COVID-19. Results Molecular docking studies indicated that hybrids of artemisinin and thymoquinone showed a relevant interaction with the active fraction of the enzyme Mpro, when compared to the reference drugs. Furthermore, hybrids show an improvement in the interaction of substances with the enzyme, mainly due to the higher frequency of interactions with the Thr199 residue. ADMET studies indicated that hybrids tend to permeate biological membranes, allowing good human intestinal absorption, with low partition to the central nervous system, potentiation for CYP-450 enzyme inhibitors, low risk of toxicity compared to commercially available drugs, considering mainly mutagenicity and cardiotoxicity, low capacity of hybrids to permeate the blood–brain barrier, high absorption and moderate permeability in Caco-2 cells. In addition, T1–T7 tend to have a better distribution of their available fractions to carry out diffusion and transport across cell membranes, as well as increase the energy of interaction with the SARS-CoV-2 target. Conclusions Hybrid products of artemisinin and thymoquinone have the potential to inhibit Mpro, with desirable pharmacokinetic and toxicity characteristics compared to commercially available drugs, being indicated for preclinical and subsequent clinical studies against SARS-CoV-2. Emphasizing the possibility of synergistic use with currently used drugs in order to increase half-life and generate a possible synergistic effect. This work represents an important step for the development of specific drugs against COVID-19.

Septoria passerinii. [Descriptions of Fungi and Bacteria].

1970 ◽  
Author(s):  
E. Punithalingam
Keyword(s):  
Geographical Distribution ◽  
Crop Residues ◽  
Poa Pratensis ◽  
Lolium Multiflorum ◽  
Barley Straw ◽  
Linear Lesions ◽  
Hordeum Jubatum ◽  
Combine Harvester ◽  
Sitanion Hystrix ◽  
Hystrix Patula

Abstract A description is provided for Septoria passerinii. Information is included on the disease caused by the organism, its transmission, geographical distribution, and hosts. HOSTS: On Hordeum brachyantherum, Hordeum distichon, Hordeum jubatum, Hordeum secalinum, Hordeum vulgare, Hystrix patula, Lolium multiflorum, L. perenne, L. temulentum, Poa pratensis and Sitanion hystrix. DISEASE: Speckled leaf blotch of barley. Forming linear lesions with indefinite margins on leaves with very small, dark brown pycnidia embedded in tissues developing on straw-coloured blotches and causing defoliation, low yields and formation of light kernels. GEOGRAPHICAL DISTRIBUTION: Africa (Ethiopia, Libya); Australasia & Oceania (Australia); Europe (Bulgaria, Cyprus, Denmark, Germany, Italy, Netherlands, Rumania, Spain, U.K.); North America (Canada, U.S.A.). TRANSMISSION: The pathogen overwinters as mycelium or as pycnidia in crop residues, producing macrospores and microspores the following summer. High humidity (>93% R.H.) is required for the release of spores which are formed abundantly on infected material after rain. Spores may be spread by insects or splashing raindrops (44, 1528; 46, 106; 40: 530). Dissemination of the pathogen on barley straw residues has also been attributed to the use of combine harvester-threshers in Western Canada (35: 418) and to high winds in Minnesota, U.S.A. (40: 530).

scholarly journals Influence of molecular weight upon mannosylated bio-synthetic hybrids for targeted antigen presenting cell gene delivery

Biomaterials ◽  
2015 ◽  
Vol 58 ◽  
pp. 103-111 ◽  
Author(s):  
Charles H. Jones ◽  
Akhila Gollakota ◽  
Mingfu Chen ◽  
Tai-Chun Chung ◽  
Anitha Ravikrishnan ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Gene Delivery ◽  
Antigen Presenting Cell ◽  
Synthetic Hybrids ◽  
Antigen Presenting ◽  
Cell Gene

Structured Synthetic Hybrids

2015 ◽  
pp. 411-418
Keyword(s):  
Synthetic Hybrids

scholarly journals Re‐creating Ancient Hybrid Species’ Complex Phenotypes from Early‐Generation Synthetic Hybrids: Three Examples Using Wild Sunflowers

2005 ◽  
Vol 166 (1) ◽  
pp. 26-41 ◽  
Author(s):  
David M. Rosenthal ◽  
Loren H. Rieseberg ◽  
Lisa A. Donovan
Keyword(s):  
Species Complex ◽  
Early Generation ◽  
Hybrid Species ◽  
Complex Phenotypes ◽  
Synthetic Hybrids
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