The Cell in Medical Science. Volume 3: Cellular Specialization (Continued).F. Beck , J. B. LloydThe Cell in Medical Science. Volume 4: Cellular Control Mechanisms; Cellular Responses to Environment.F. Beck , J. B. Lloyd

1977 ◽  
Vol 52 (2) ◽  
pp. 194-194
Author(s):  
Vincent Pigiet



2013 ◽  
Vol 5 (2) ◽  
pp. 143-145 ◽  
Author(s):  
Arpan Kumar Dey ◽  
Pijush Kanti Mandal ◽  
Agnibha Dutta ◽  
Subhraprakash Pramanik ◽  
Saurabh Maji ◽  
...  

Hydatid cyst may be found in almost any part of the body, but most often in the liver and the lungs. Other organs affected occasionally include the brain, muscle, kidney, heart, pancreas, adrenal, and thyroid gland. Hydatidosis located in the thyroid is an infrequent finding, even in endemic regions. This report documents a rare case with a cystic nodule in the thyroid detected by ultrasonography. The patient was a 30-year-old woman with an euthyroid multinodular goitre. Ultrasonography revealed a cystic nodule, and the ultrasonic appearance of the cyst liquid showed multiple echoes, suggesting that the nodule could be a hydatid cyst. The histopathologic examinations confirmed this to be a primary hydatid cyst of thyroid. During the differential diagnosis of the cystic thyroid lesions, hydatid disease of the thyroid gland should be considered in endemic areas. Chemotherapy is necessary to avoid recurrence. DOI: http://dx.doi.org/10.3126/ajms.v5i2.8830 Asian Journal of Medical Science, Volume-5(2) 2014: 143-145



Author(s):  
Knut Blind

Besides these very conceptual or theoretical approaches to deal with standards dynamics, several case study analyses exist, which focus on the standard maintenance and succession (Egyedi, Loeffen 2002) in order to answer the question how to deal with heritage relations between standards and on standard integrity (Egyedi, Hudson 2005) and in order to discuss control mechanisms that safeguard the integrity of (de facto) standards. This paper adds an additional methodological dimension to the analysis of the dynamics of standards by a strong focus on the life times of standards. The contribution of this paper to the emerging research on the dynamics of standards is twofold. First, the descriptive presentation of life times of standards focusing both on average publication years and survival times reflects on the one hand the historical development of ICT over time and on the other hand its dynamics in the various subfields. So far other indicators like scientific publications or patent applications are used to describe the development especially of new technologies, e. g. biotechnology or nanotechnology. The analysis of publications of standard documents extends the former exercises by a new more market and diffusion related dimension. Second, the characteristics of standard documents are used to explain their life times. Here we borrow for the first time general approaches from bibliometrics and patent analysis in order to explain life times of standards as indicator for their value by documents’ characteristics. The remainder of the paper is structured as follows. First, we analyse the average lifetimes of standards in a quantitative manner, taking into account differences between countries. Since the simple approach of calculating the average lifetimes of historical standards does not allow us to include standards which are still alive, we have to apply a more sophisticated methodology, the so-called survival analysis, which was initially mainly applied in medical science. The application of this statistical approach produces average lifetimes of standards, taking into account the expected lifetime of standards which are still valid. This approach is crucial, especially for the analysis of ICT standards, because the number of valid standards relative to historical standards is rather high. Due to the very high relevance of international standards in the ICT sector and the high quality of this subsample, we concentrate the survival analysis espeically on the international standards including the standards released by the European standardisation bodies. The results of this analysis provide us with new insights about the expected lifetimes of standards differentiated by technology in the ICT area. The final step of our analysis tries to answer the question which causal factors influence the lifetimes of standards in the ICT sector. We present first insights by applying the so-called Cox regression, which allows us to identify whether some selected characteristics of a standard, like cross references or references to international standards, have a significant impact on its actual or expected lifetime. The approach to assess the importance of a technical document by analysing its references to other documents or being referenced in other documents has a long tradition in evaluating the value of patents by counting and analysing their citations. The paper concludes with a brief summary of the main results, but also with some general recommendations regarding standardisation processes and the maintenance of standards derived from the new insights.



2014 ◽  
Vol 5 (3) ◽  
pp. 10-14 ◽  
Author(s):  
Amit Gupta ◽  
SK Jain ◽  
Sunil Kumar ◽  
RCM Kaza

Inguinal hernia repair using mesh is one of the most frequently performed operations in general surgery. The mesh can be placed using an open technique or by laparoscopic approach. Many studies have highlighted the merits and risks of laparoscopic approach for the repair of inguinal hernia, the final sentence still remains to be written as majority of trials are too small to show clear benefits of one technique over another. To compare laparoscopic mesh repair with open method in management of inguinal hernia. Asian Journal of Medical Science, Volume-5(3) 2014: 11-14 DOI: http://dx.doi.org/10.3126/ajms.v5i3.9301 







2009 ◽  
Vol 296 (2) ◽  
pp. G414-G423 ◽  
Author(s):  
Simon Almeida-Vega ◽  
Krista Catlow ◽  
Susan Kenny ◽  
Rod Dimaline ◽  
Andrea Varro

The gastric hormone gastrin regulates the expression of a variety of genes involved in control of acid secretion and also in the growth and organization of the gastric mucosa. One putative target is plasminogen activator inhibitor-2 (PAI-2), which is a component of the urokinase activator system that acts extracellularly to inhibit urokinase plasminogen activator (uPA) and intracellularly to suppress apoptosis. Previous studies have demonstrated that gastrin induces PAI-2 both in gastric epithelial cells expressing the gastrin (CCK-2) receptor and, via activation of paracrine networks, in adjacent cells that do not express the receptor. We have now sought to identify the response element(s) in the PAI-2 promoter targeted by paracrine mediators initiated by gastrin. Mutational analysis identified two putative response elements in the PAI-2 promoter that were downstream of gastrin-activated paracrine signals. One was identified as a putative MAZ site, mutation of which dramatically reduced both basal and gastrin-stimulated responses of the PAI-2 promoter by a mechanism involving PGE2 and the small GTPase RhoA. Yeast one-hybrid screening identified the other as binding the activating signal cointegrator-1 (ASC-1) complex, which was shown to be the target of IL-8 released by gastrin. RNA interference (RNAi) knockdown of two subunits of the ASC-1 complex (p50 and p65) inhibited induction of PAI-2 expression by gastrin. The data reveal previously unsuspected transcriptional mechanisms activated as a consequence of gastrin-triggered paracrine networks and emphasize the elaborate and complex cellular control mechanisms required for a key component of tissue responses to damage and infection.



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