scholarly journals Distinct Mechanisms for Mitochondrial DNA Loss in T and B Lymphocytes from HIV‐Infected Patients Exposed to Nucleoside Reverse‐Transcriptase Inhibitors and Those Naive to Antiretroviral Treatment

2008 ◽  
Vol 198 (10) ◽  
pp. 1474-1481 ◽  
Author(s):  
Anne Maagaard ◽  
Mona Holberg‐Petersen ◽  
Gunilla Løvgården ◽  
Malin Holm ◽  
Frank Olav Pettersen ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Reverse Transcriptase ◽  
B Lymphocytes ◽  
Antiretroviral Treatment ◽  
T And B Lymphocytes ◽  
Reverse Transcriptase Inhibitors ◽  
Nucleoside Reverse Transcriptase Inhibitors ◽  
Dna Loss

Effects of apricitabine and other nucleoside reverse transcriptase inhibitors on replication of mitochondrial DNA in HepG2 cells

2007 ◽  
Vol 76 (1) ◽  
pp. 68-74 ◽  
Author(s):  
M DEBAAR ◽  
E DEROOIJ ◽  
K SMOLDERS ◽  
H VANSCHIJNDEL ◽  
E TIMMERMANS ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Reverse Transcriptase ◽  
Hepg2 Cells ◽  
Reverse Transcriptase Inhibitors ◽  
Nucleoside Reverse Transcriptase Inhibitors

scholarly journals Mitochondrial and Metabolic Effects of Nucleoside Reverse Transcriptase Inhibitors (NRTIs) in Mice Receiving One of Five Single- and Three Dual-NRTI Treatments

2003 ◽  
Vol 47 (11) ◽  
pp. 3384-3392 ◽  
Author(s):  
Reine Note ◽  
Caroline Maisonneuve ◽  
Philippe Lettéron ◽  
Gilles Peytavin ◽  
Fatima Djouadi ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Reverse Transcriptase ◽  
Ketone Bodies ◽  
Metabolic Effects ◽  
Reverse Transcriptase Inhibitors ◽  
Nucleoside Reverse Transcriptase Inhibitors ◽  
Aminoisobutyric Acid ◽  
Mitochondrial Fatty Acid ◽  
High Doses ◽  
Cpt I

ABSTRACT Although treatments with nucleoside reverse transcriptase inhibitors (NRTIs) can modify fat metabolism and fat distribution in humans, the mechanisms of these modifications and the roles of diverse NRTIs are unknown. We studied the mitochondrial and metabolic effects of stavudine (d4T), zidovudine (AZT), didanosine (ddI), lamivudine (3TC), zalcitabine (ddC), and three combinations (AZT-3TC, d4T-3TC, and d4T-ddI) in mice treated for 2 weeks with daily doses equivalent to the human dose per body area. Concentrations of AZT and d4T in plasma were lower when these drugs were administered with 3TC or ddI. Whatever the treatment, mitochondrial DNA was not significantly decreased in muscle, heart, brain, or white adipose tissue but was moderately decreased in liver tissue after the administration of AZT, 3TC, or d4T alone. Blood lactate was unchanged, even when NRTIs were administered at supratherapeutic doses. In contrast, the level of plasma ketone bodies increased with the administration of AZT or high doses of d4T but not with ddC, 3TC, or ddI, suggesting that the thymine moiety could be involved. Indeed, the levels of plasma ketone bodies increased in mice treated with β-aminoisobutyric acid, a thymine catabolite. Treatment with AZT, d4T, or β-aminoisobutyric acid increased hepatic carnitine palmitoyltransferase I (CPT-I) mRNA expression and the mitochondrial generation of ketone bodies from palmitate. In conclusion, therapeutic doses of NRTIs have no or moderate effects on mitochondrial DNA and no effects on plasma lactate in mice. However, AZT and high doses of d4T increase the levels of hepatic CPT-I, mitochondrial fatty acid β-oxidation, and ketone bodies, and these catabolic effects are reproduced by β-aminoisobutyric acid, a thymine metabolite.

scholarly journals Antiretroviral treatment outcome following genotyping in Thai children who failed dual nucleoside reverse transcriptase inhibitors

2010 ◽  
Vol 14 (4) ◽  
pp. e311-e316 ◽  
Author(s):  
Torsak Bunupuradah ◽  
Piyarat Suntarattiwong ◽  
Andrea Li ◽  
Sunee Sirivichayakul ◽  
Chitsanu Pancharoen ◽  
...  
Keyword(s):  
Treatment Outcome ◽  
Reverse Transcriptase ◽  
Antiretroviral Treatment ◽  
Reverse Transcriptase Inhibitors ◽  
Nucleoside Reverse Transcriptase Inhibitors
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