Non-invasive wearable seizure detection using long-short term memory networks with transfer learning

Author(s):  
Mona Nasseri ◽  
Tal Pal Attia ◽  
Boney Joseph ◽  
Nicholas Gregg ◽  
Ewan Nurse ◽  
...  
2020 ◽  
Vol 18 (1) ◽  
pp. 47-59
Author(s):  
Marcelo Romero ◽  
Matheusq Gutoski ◽  
Leandro Takeshi Hattori ◽  
Manassés Ribeiro ◽  
Heitor S. Lopes

Author(s):  
Guoyang Liu ◽  
Lan Tian ◽  
Weidong Zhou

Automatic seizure detection is of great significance for epilepsy diagnosis and alleviating the massive burden caused by manual inspection of long-term EEG. At present, most seizure detection methods are highly patient-dependent and have poor generalization performance. In this study, a novel patient-independent approach is proposed to effectively detect seizure onsets. First, the multi-channel EEG recordings are preprocessed by wavelet decomposition. Then, the Convolutional Neural Network (CNN) with proper depth works as an EEG feature extractor. Next, the obtained features are fed into a Bidirectional Long Short-Term Memory (BiLSTM) network to further capture the temporal variation characteristics. Finally, aiming to reduce the false detection rate (FDR) and improve the sensitivity, the postprocessing, including smoothing and collar, is performed on the outputs of the model. During the training stage, a novel channel perturbation technique is introduced to enhance the model generalization ability. The proposed approach is comprehensively evaluated on the CHB-MIT public scalp EEG database as well as a more challenging SH-SDU scalp EEG database we collected. Segment-based average accuracies of 97.51% and 93.70%, event-based average sensitivities of 86.51% and 89.89%, and average AUC-ROC of 90.82% and 90.75% are yielded on the CHB-MIT database and SH-SDU database, respectively.


Author(s):  
Mahendra Awale ◽  
Finton Sirockin ◽  
Nikolaus Stiefl ◽  
Jean-Louis Reymond

<p>Several recent reports have shown that long short-term memory generative neural networks (LSTM) of the type used for grammar learning efficiently learn to write SMILES of drug-like compounds when trained with SMILES from a database of bioactive compounds such as ChEMBL and can later produce focused sets upon transfer learning with compounds of specific bioactivity profiles. Here we trained an LSTM using molecules taken either from ChEMBL, DrugBank, commercially available fragments, or from FDB-17 (a database of fragments up to 17 atoms) and performed transfer learning to a single known drug to obtain new analogs of this drug. We found that this approach readily generates hundreds of relevant and diverse new drug analogs and works best with training sets of around 40,000 compounds as simple as commercial fragments. These data suggest that fragment-based LSTM offer a promising method for new molecule generation.</p>


2020 ◽  
Vol 10 (7) ◽  
pp. 442 ◽  
Author(s):  
You Wang ◽  
Ming Zhang ◽  
RuMeng Wu ◽  
Han Gao ◽  
Meng Yang ◽  
...  

Silent speech decoding is a novel application of the Brain–Computer Interface (BCI) based on articulatory neuromuscular activities, reducing difficulties in data acquirement and processing. In this paper, spatial features and decoders that can be used to recognize the neuromuscular signals are investigated. Surface electromyography (sEMG) data are recorded from human subjects in mimed speech situations. Specifically, we propose to utilize transfer learning and deep learning methods by transforming the sEMG data into spectrograms that contain abundant information in time and frequency domains and are regarded as channel-interactive. For transfer learning, a pre-trained model of Xception on the large image dataset is used for feature generation. Three deep learning methods, Multi-Layer Perception, Convolutional Neural Network and bidirectional Long Short-Term Memory, are then trained using the extracted features and evaluated for recognizing the articulatory muscles’ movements in our word set. The proposed decoders successfully recognized the silent speech and bidirectional Long Short-Term Memory achieved the best accuracy of 90%, outperforming the other two algorithms. Experimental results demonstrate the validity of spectrogram features and deep learning algorithms.


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