scholarly journals Automatic segmentation of low-grade glioma in MRI image based on UNet++ model

2020 ◽  
Vol 1693 ◽  
pp. 012135
Author(s):  
Dan Xu ◽  
Xidong Zhou ◽  
Xuefen Niu ◽  
Junwei Wang
Keyword(s):  
Automatic Segmentation ◽  
Low Grade Glioma ◽  
Low Grade ◽  
Mri Image

scholarly journals EASE: Clinical Implementation of Automated Tumor Segmentation and Volume Quantification for Adult Low-Grade Glioma

2021 ◽  
Vol 8 ◽  
Author(s):  
Karin A. van Garderen ◽  
Sebastian R. van der Voort ◽  
Adriaan Versteeg ◽  
Marcel Koek ◽  
Andrea Gutierrez ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Automatic Segmentation ◽  
Low Grade Glioma ◽  
Tumor Segmentation ◽  
Low Grade ◽  
Clinical Implementation ◽  
Volumetric Assessment ◽  
Ensure Patient Safety ◽  
Volume Measurements ◽  
The Individual

The growth rate of non-enhancing low-grade glioma has prognostic value for both malignant progression and survival, but quantification of growth is difficult due to the irregular shape of the tumor. Volumetric assessment could provide a reliable quantification of tumor growth, but is only feasible if fully automated. Recent advances in automated tumor segmentation have made such a volume quantification possible, and this work describes the clinical implementation of automated volume quantification in an application named EASE: Erasmus Automated SEgmentation. The visual quality control of segmentations by the radiologist is an important step in this process, as errors in the segmentation are still possible. Additionally, to ensure patient safety and quality of care, protocols were established for the usage of volume measurements in clinical diagnosis and for future updates to the algorithm. Upon the introduction of EASE into clinical practice, we evaluated the individual segmentation success rate and impact on diagnosis. In its first 3 months of usage, it was applied to a total of 55 patients, and in 36 of those the radiologist was able to make a volume-based diagnosis using three successful consecutive measurements from EASE. In all cases the volume-based diagnosis was in line with the conventional visual diagnosis. This first cautious introduction of EASE in our clinic is a valuable step in the translation of automatic segmentation methods to clinical practice.

Development of a novel assay suitable for pre-clinical testing of MAPK inhibitors in low-grade glioma

2017 ◽  
Author(s):  
D Usta ◽  
F Selt ◽  
J Hohloch ◽  
S Pusch ◽  
SM Pfister ◽  
...  
Keyword(s):  
Low Grade Glioma ◽  
Low Grade ◽  
Clinical Testing ◽  
Mapk Inhibitors

scholarly journals Discovery of a rare GKAP1-NTRK2 fusion in a pediatric low-grade glioma, leading to targeted treatment with TRK-inhibitor larotrectinib

2021 ◽  
Vol 22 (3) ◽  
pp. 184-195
Author(s):  
Lily Deland ◽  
Simon Keane ◽  
Thomas Olsson Bontell ◽  
Helene Sjögren ◽  
Henrik Fagman ◽  
...  
Keyword(s):  
Low Grade Glioma ◽  
Targeted Treatment ◽  
Low Grade

scholarly journals Glioma with Leptomeningeal Spread Mimics Chronic Meningoencephalitis in a Young Adult

2021 ◽  
pp. 179-183
Author(s):  
Ann-Kristin Becker ◽  
Marta Leonora Frank ◽  
Michael Friese ◽  
Joachim Röther
Keyword(s):  
Brain Tumor ◽  
Back Pain ◽  
Young Adult ◽  
Lower Back Pain ◽  
Low Grade Glioma ◽  
Low Grade ◽  
Who Grade ◽  
Leptomeningeal Spread ◽  
Lower Back ◽  
Uncommon Case

The most malignant type of intrinsic brain tumor is glioblastoma (WHO grade IV). Primary leptomeningeal spread is rare and leads to a variety of differential considerations, as there is no typical clinical or imaging pattern. Here we present a rare and uncommon case of a primary leptomeningeal glioblastoma in combination with a low-grade glioma in a 21-year-old male, initially presenting with only headache and lower back pain. The presented case illustrates the challenging differential considerations and the severe course of leptomeningeal glioblastomas.

scholarly journals A survival analysis of surgically treated incidental low-grade glioma patients

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Lingcheng Zeng ◽  
Qi Mei ◽  
Hua Li ◽  
Changshu Ke ◽  
Jiasheng Yu ◽  
...  
Keyword(s):  
Progression Free Survival ◽  
Low Grade Glioma ◽  
Low Grade ◽  
Total Resection ◽  
Surgical Timing ◽  
Asymptomatic Group ◽  
Free Survival ◽  
Symptomatic Group ◽  
Significant Difference ◽  
Asymptomatic Phase

AbstractTo evaluate the surgical effect on survival in patients with incidental low-grade glioma (LGG) through comparison between asymptomatic and symptomatic patients. The medical records of surgically treated adult cerebral incidental LGG (iLGG) patients in our department between January 2008 and December 2015 were retrospectively reviewed. The survival of patients was calculated starting from the initial imaging diagnosis. Factors related to progression-free survival (PFS), overall survival (OS) and malignant progression-free survival (MPFS) were statistically analyzed. Seventy-five iLGG patients underwent surgery: 49 in the asymptomatic group, who underwent surgery in the asymptomatic period, and 26 in the symptomatic group, who underwent surgery after the tumor had grown and the patients had developed tumor-related symptoms. Significantly more tumors were initially located adjacent to the functional area in the symptomatic group than in the asymptomatic group (P < 0.05), but there was no significant difference in the total resection rate between the two groups. The incidence of postoperative complications (15.4%) and postoperative epilepsy (23.1%) was higher in the symptomatic group than in the asymptomatic group (4.1% and 10.2%, respectively). Multivariate analysis showed that surgical timing, namely, surgery performed before or after symptom occurrence, had no significant effect on PFS, OS or MPFS, while total resection significantly prolonged PFS, OS and MPFS, and the pathology of oligodendroglioma was positively correlated with PFS and OS (P < 0.05). Surgical timing for iLGGs should facilitate total resection. If total resection can be achieved, even after symptom occurrence, patients can achieve comparable survival benefits to those treated with surgery in the asymptomatic phase.

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