Spectral-detector based x-ray absorptiometry (SDXA): in-vivo bone mineral density measurements in patients with and without osteoporotic fractures

Clinical psychological factors may predict medical diseases. Anxiety level has been associated with osteoporosis, but its role on bone mineral density (BMD) change is still unknown. This study aimed to investigate the association between anxiety levels and both adherence and treatment response to oral bisphosphonates (BPs) in postmenopausal osteoporosis. BMD and anxiety levels were evaluated trough dual-energy X-ray absorptiometry and the Hamilton Anxiety Rating Scale (HAM-A), respectively. Participants received weekly medication with alendronate or risedronate and were grouped according to the HAM-A scores into tertiles (HAM-A 3 > HAM-A 2 > HAM-A 1). After 24 months, BMD changes were different among the HAM-A tertiles. The median lumbar BMD change was significantly greater in both the HAM-A 2 and HAM-A 3 in comparison with the HAM-A 1. The same trend was observed for femoral BMD change. Adherence to BPs was >75% in 68% of patients in the HAM-A 1, 79% of patients in the HAM-A 2, and 89% of patients in the HAM-A 3 (p = 0.0014). After correcting for age, body mass index, depressive symptoms, and the 10-yr. probability of osteoporotic fractures, anxiety levels independently predicted lumbar BMD change (β = 0.3417, SE 0.145, p = 0.02). In conclusion, women with higher anxiety levels reported greater BMD improvement, highlighting that anxiety was associated with adherence and response to osteoporosis medical treatment, although further research on this topic is needed.

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In vivo measurement of mandibular bone mineral density in normal dental subjects by dual-energy X-ray absorptiometry (DEXA)

Bone ◽

10.1016/s8756-3282(96)90731-0 ◽

1996 ◽

Vol 19 (3) ◽

pp. 130

Author(s):

A. Apostolopoulou ◽

A. Yatzides ◽

B. Magiasis ◽

G. Lyritis

Keyword(s):

Bone Mineral Density ◽

Bone Mineral ◽

Dual Energy ◽

Mineral Density ◽

Mandibular Bone ◽

X Ray ◽

In Vivo Measurement

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Bone Mineral Densities and Mechanical Properties of Retrieved Femoral Bone Samples in relation to Bone Mineral Densities Measured in the Respective Patients

The Scientific World JOURNAL ◽

10.1100/2012/242403 ◽

2012 ◽

Vol 2012 ◽

pp. 1-7 ◽

Cited By ~ 10

Author(s):

Yvonne Haba ◽

Ralf Skripitz ◽

Tobias Lindner ◽

Martin Köckerling ◽

Andreas Fritsche ◽

...

Keyword(s):

Mechanical Properties ◽

Bone Mineral Density ◽

Femoral Head ◽

Bone Mineral ◽

Hip Replacement ◽

Dual Energy ◽

Femoral Bone ◽

Mineral Density ◽

X Ray

The bone mineral density (BMD) of retrieved cancellous bone samples is compared to the BMD measuredin vivoin the respective osteoarthritic patients. Furthermore, mechanical properties, in terms of structural modulus (Es) and ultimate compression strength (σmax) of the bone samples, are correlated to BMD data. Human femoral heads were retrieved from 13 osteoarthritic patients undergoing total hip replacement. Subsequently, the BMD of each bone sample was analysed using dual energy X-ray absorptiometry (DXA) as well as ashing. Furthermore, BMDs of the proximal femur were analysed preoperatively in the respective patients by DXA. BMDs of the femoral neck and head showed a wide variation, from1016±166 mg/cm2to1376±404 mg/cm2. BMDs of the bone samples measured by DXA and ashing yielded values of315±199 mg/cm2and347±113 mg/cm3, respectively.Esandσmaxamounted to232±151 N/mm2and6.4±3.7 N/mm2. Significant correlation was found between the DXA and ashing data on the bone samples and the DXA data from the patients at the femoral head (r=0.85and 0.79, resp.).Escorrelated significantly with BMD in the patients and bone samples as well as the ashing data (r=0.79,r=0.82, andr=0.8, resp.).

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The Effect of the Lumbar Vertebral Malpositioning on Bone Mineral Density Measurements of the Lumbar Spine by Dual-Energy X-Ray Absorptiometry

Journal of Clinical Densitometry ◽

10.1016/j.jocd.2015.12.001 ◽

2016 ◽

Vol 19 (3) ◽

pp. 277-281 ◽

Cited By ~ 6

Author(s):

Sina Izadyar ◽

Shima Golbarg ◽

Abbas Takavar ◽

Seyed Salman Zakariaee

Keyword(s):

Bone Mineral Density ◽

Lumbar Spine ◽

Bone Mineral ◽

Dual Energy ◽

Mineral Density ◽

Density Measurements ◽

X Ray

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Enhancement of Prediction for Hip Fractures Using Stochastic Assessment of Bone Mineral Density Distribution From DXA Images

Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments ◽

10.1115/sbc2013-14227 ◽

2013 ◽

Author(s):

Xuanliang Neil Dong ◽

Patricia Cussen ◽

Timothy Lowe ◽

David Di Paolo ◽

Joyce Ballard

Keyword(s):

Bone Mineral Density ◽

Bone Mineral ◽

Hip Fractures ◽

Bone Fractures ◽

Osteoporotic Fractures ◽

Mineral Density ◽

X Ray ◽

Increasing Risk ◽

Fracture Risks ◽

Bone Mineral Density Distribution

Hip fractures are among the most common types of osteoporotic fractures that affect one in three women and one in six men over the age of 50 [1]. It is well known that loss of bone mass, quantified by bone mineral density using Dual-energy X-ray Absorptiometry (DXA), is associated with the increasing risk of bone fractures. However, bone mineral density (BMD) alone cannot fully explain changes in fracture risks [2, 3]. In particular, BMD is not able to predict fracture risks for women with osteopenia, in which a BMD T-score is between −1.0 and −2.5. This suggests additional factors (i.e., bone quality) should be considered in predicting fracture risks [4].

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