Vaccination of Cats with Recombinant Envelope Glycoprotein of Feline Immunodeficiency Virus: Decreased Viral Load after Challenge Infection

1996 ◽  
Vol 12 (5) ◽  
pp. 431-433 ◽  
Author(s):  
H. LUTZ ◽  
R. HOFMANN-LEHMANN ◽  
C. LEUTENEGGER ◽  
K. ALLENSPACH ◽  
A.M. CUISINIER ◽  
...  
Keyword(s):  
Viral Load ◽  
Feline Immunodeficiency Virus ◽  
Envelope Glycoprotein ◽  
Challenge Infection ◽  
Immunodeficiency Virus

scholarly journals Antibodies specific for hypervariable regions 3 to 5 of the feline immunodeficiency virus envelope glycoprotein are not solely responsible for vaccine-induced acceleration of challenge infection in cats

2004 ◽  
Vol 85 (7) ◽  
pp. 1833-1841 ◽  
Author(s):  
Willem Huisman ◽  
Eefje J. A. Schrauwen ◽  
Suzan D. Pas ◽  
Jos A. Karlas ◽  
Guus F. Rimmelzwaan ◽  
...  
Keyword(s):  
Feline Immunodeficiency Virus ◽  
Envelope Glycoprotein ◽  
Challenge Infection ◽  
Antibody Responses ◽  
Causative Role ◽  
Virus Envelope ◽  
Humoral Immune ◽  
Hypervariable Regions ◽  
Immunodeficiency Virus

In a previous vaccination study in cats, the authors reported on accelerated feline immunodeficiency virus (FIV) replication upon challenge in animals vaccinated with a candidate envelope subunit vaccine. Plasma transfer studies as well as antibody profiles in vaccinated cats indicated a causative role for antibodies directed against the hypervariable regions HV3, HV4 and HV5 (HV3–5) of the envelope glycoprotein. The present study was designed to investigate further the contribution of antibodies in envelope vaccine-induced acceleration of FIV infection. To this end, regions HV3–5 of the envelope glycoprotein were deleted from the original vaccine, thus addressing the contributing role of antibodies directed against these hypervariable regions. Interestingly, this approach did not prevent acceleration of challenge infection. Analysis of the antibody responses in the respective groups suggested that removal of HV3–5 redirected the humoral immune response towards other regions of the envelope glycoprotein, indicating that these regions can also induce antibodies that accelerate virus replication.

scholarly journals Mechanism of feline immunodeficiency virus envelope glycoprotein-mediated fusion

Virology ◽  
2004 ◽  
Vol 321 (2) ◽  
pp. 274-286 ◽  
Author(s):  
Himanshu Garg ◽  
Frederick J. Fuller ◽  
Wayne A.F. Tompkins
Keyword(s):  
Feline Immunodeficiency Virus ◽  
Envelope Glycoprotein ◽  
Virus Envelope ◽  
Immunodeficiency Virus
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