Activation of HIV Type 1 Specific Cytotoxic T Lymphocytes from Semen by HIV Type 1 Antigen-Presenting Dendritic Cells and IL-12

2006 ◽  
Vol 22 (1) ◽  
pp. 93-98 ◽  
Author(s):  
Xiao-Li Huang ◽  
Zheng Fan ◽  
Phalguni Gupta ◽  
Charles R. Rinaldo
Keyword(s):  
Dendritic Cells ◽  
T Lymphocytes ◽  
Cytotoxic T Lymphocytes ◽  
Hiv Type 1 ◽  
Antigen Presenting

scholarly journals Distinct Recognition of Non-Clade B Human Immunodeficiency Virus Type 1 Epitopes by Cytotoxic T Lymphocytes Generated from Donors Infected in Africa

1999 ◽  
Vol 73 (2) ◽  
pp. 1708-1714 ◽  
Author(s):  
Lucy Dorrell ◽  
Tao Dong ◽  
Graham S. Ogg ◽  
Simon Lister ◽  
Steve McAdam ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Lymphocytes ◽  
Cytotoxic T Lymphocytes ◽  
Human Immunodeficiency Virus Type ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Clade B ◽  
Immunodeficiency Virus ◽  
Hiv Type 1

ABSTRACT We present detailed studies of human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte (CTL) responses to clade A or C HIV type 1 in three donors infected in East Africa. We define several novel non-clade B CTL epitopes, including some restricted by HLA alleles common in Africans. Although cross-clade CTL recognition of these epitopes does occur, recognition can also be highly clade specific.

scholarly journals Mesoporous Silicon Microparticles Enhance MHC Class I Cross-Antigen Presentation by Human Dendritic Cells

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
A. Jiménez-Periáñez ◽  
B. Abos Gracia ◽  
J. López Relaño ◽  
C. M. Diez-Rivero ◽  
P. A. Reche ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Lymphocytes ◽  
Mhc Class I ◽  
Cytotoxic T Lymphocytes ◽  
Class I ◽  
Antigenic Peptides ◽  
Mesoporous Silicon ◽  
Human Dendritic Cells ◽  
Antigen Presenting ◽  
First Time

The mesoporous silicon microparticles (MSMPs) are excellent vehicles for releasing molecules inside the cell. The aim of this work was to use MSMPs to deliver viral specific MHC class I restricted epitopes into human antigen presenting cells (monocyte derived dendritic cells, MDDCs) to facilitate their capture, processing, and presentation to CD8+ (cytotoxic) T lymphocytes. We show for the first time that MSMPs vehiculation of antigenic peptides enhances their MHC class I presentation by human MDDCs to CD8 T lymphocytes.

scholarly journals Cytotoxic T lymphocytes and viral turnover in HIV type 1 infection

1996 ◽  
Vol 93 (26) ◽  
pp. 15323-15328 ◽  
Author(s):  
P. Klenerman ◽  
R. E. Phillips ◽  
C. R. Rinaldo ◽  
L. M. Wahl ◽  
G. Ogg ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Cytotoxic T Lymphocytes ◽  
Hiv Type 1

Isolation of Cytomegalovirus-Specific Cytotoxic T-Lymphocytes from Gut-Associated Lymphoid Tissue (GALT) of HIV Type 1-Infected Subjects

2000 ◽  
Vol 16 (12) ◽  
pp. 1157-1162 ◽  
Author(s):  
Barbara L. Shacklett ◽  
Thomas J. Beadle ◽  
Paulo A. Pacheco ◽  
James H. Grendell ◽  
Patrick A. J. Haslett ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Cytotoxic T Lymphocytes ◽  
Lymphoid Tissue ◽  
Hiv Type 1

scholarly journals Antigen-Specific Polyclonal Cytotoxic T Lymphocytes Induced by Fusions of Dendritic Cells and Tumor Cells

2010 ◽  
Vol 2010 ◽  
pp. 1-12 ◽  
Author(s):  
Shigeo Koido ◽  
Sadamu Homma ◽  
Eiichi Hara ◽  
Yoshihisa Namiki ◽  
Toshifumi Ohkusa ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Lymphocytes ◽  
Immune Responses ◽  
Tumor Cells ◽  
Cytotoxic T Lymphocytes ◽  
Alternative Approach ◽  
Antigen Presenting ◽  
Ctl Induction ◽  
Secondary Lymphoid Organs ◽  
Powerful Strategy

The aim of cancer vaccines is induction of tumor-specific cytotoxic T lymphocytes (CTLs) that can reduce the tumor mass. Dendritic cells (DCs) are potent antigen-presenting cells and play a central role in the initiation and regulation of primary immune responses. Thus, DCs-based vaccination represents a potentially powerful strategy for induction of antigen-specific CTLs. Fusions of DCs and whole tumor cells represent an alternative approach to deliver, process, and subsequently present a broad spectrum of antigens, including those known and unidentified, in the context of costimulatory molecules. Once DCs/tumor fusions have been infused back into patient, they migrate to secondary lymphoid organs, where the generation of antigen-specific polyclonal CTL responses occurs. We will discuss perspectives for future development of DCs/tumor fusions for CTL induction.

scholarly journals Inhibition of Human Immunodeficiency Virus Type 1 Replication in Primary CD4+ T Lymphocytes, Monocytes, and Dendritic Cells by Cytotoxic T Lymphocytes

2000 ◽  
Vol 74 (14) ◽  
pp. 6695-6699 ◽  
Author(s):  
Michael E. Severino ◽  
Nikolaos V. Sipsas ◽  
Phuong Thi Nguyen ◽  
Spyros A. Kalams ◽  
Bruce D. Walker ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Dendritic Cells ◽  
T Lymphocytes ◽  
Cytotoxic T Lymphocytes ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Viral Inhibition ◽  
Immunodeficiency Virus ◽  
Hiv 1

ABSTRACT We demonstrate that human immunodeficiency virus type 1 (HIV-1)-specific CD8+ cytotoxic T lymphocytes (CTL) suppress HIV-1 replication in primary lymphocytes, monocytes, and dendritic cells individually. Viral inhibition is significantly diminished in lymphocyte-dendritic cell clusters, suggesting that these clusters in vivo could be sites where viral replication is more difficult to control by CTL.

HIV Type 1-Infected Dendritic Cells Induce Apoptotic Death in Infected and Uninfected Primary CD4 T Lymphocytes

2004 ◽  
Vol 20 (2) ◽  
pp. 175-182 ◽  
Author(s):  
Miriam Lichtner ◽  
Concepción Marañón ◽  
Olga Azocar ◽  
Daniel Hanau ◽  
Pierre Lebon ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Lymphocytes ◽  
Apoptotic Death ◽  
Hiv Type 1
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