Probabilistic Modeling of Pseudorabies Virus Infection in a Neural Circuit

2018 ◽  
Vol 25 (11) ◽  
pp. 1231-1246
Author(s):  
Siamak K. Sorooshyari ◽  
Matthew P. Taylor ◽  
H. Vincent Poor
2000 ◽  
Vol 76 (1-2) ◽  
pp. 125-135 ◽  
Author(s):  
M.G.M De Bruin ◽  
J.N Samsom ◽  
J.J.M Voermans ◽  
E.M.A van Rooij ◽  
Y.E De Visser ◽  
...  

2012 ◽  
Vol 24 (1) ◽  
pp. 246-246

JVDI 23:915–923 (September 2011) In the article entitled “Pseudorabies virus infection in Oklahoma hunting dogs” by Sarah D. Cramer et al., on page 918 in the legend to Figure 2, the legend should refer to an “intranuclear” inclusion body instead of an “intracytoplasmic” inclusion body.


2008 ◽  
Vol 83 (3) ◽  
pp. 1173-1183 ◽  
Author(s):  
D. Curanović ◽  
M. G. Lyman ◽  
C. Bou-Abboud ◽  
J. P. Card ◽  
L. W. Enquist

ABSTRACT The attenuated pseudorabies virus (PRV) strain Bartha contains several characterized mutations that affect its virulence and ability to spread through neural circuits. This strain contains a small genomic deletion that abrogates anterograde spread and is widely used as a retrograde-restricted neural circuit tracer. Previous studies showed that the retrograde-directed spread of PRV Bartha is slower than that of wild-type PRV. We used compartmented neuronal cultures to characterize the retrograde defect and identify the genetic basis of the phenotype. PRV Bartha is not impaired in retrograde axonal transport, but transneuronal spread among neurons is diminished. Repair of the UL21 locus with wild-type sequence restored efficient transneuronal spread both in vitro and in vivo. It is likely that mutations in the Bartha UL21 gene confer defects that affect infectious particle production, causing a delay in spread to presynaptic neurons and amplification of infection. These events manifest as slower kinetics of retrograde viral spread in a neural circuit.


2020 ◽  
Vol 26 (3) ◽  
pp. 442-448 ◽  
Author(s):  
Di Wang ◽  
Xiaogen Tao ◽  
Mingming Fei ◽  
Jian Chen ◽  
Wei Guo ◽  
...  

Vaccine ◽  
2005 ◽  
Vol 23 (26) ◽  
pp. 3483-3491 ◽  
Author(s):  
Daniel Dory ◽  
Anne-Marie Torché ◽  
Véronique Béven ◽  
Philippe Blanchard ◽  
Christophe Loizel ◽  
...  

1982 ◽  
Vol 18 (1) ◽  
pp. 113-116 ◽  
Author(s):  
D.G. THAWLEY ◽  
J.C. WRIGHT

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