Patients with Chronic Autoimmune Thyroiditis 
and Negative Thyroid Autoantibodies Have a 
Milder Form of the Disease

2014 ◽  
Vol 26 (7) ◽  
pp. 183-186
Author(s):  
Jacques Orgiazzi
Keyword(s):  
Autoimmune Thyroiditis ◽  
Thyroid Autoantibodies ◽  
Chronic Autoimmune Thyroiditis

scholarly journals ANTITHYROID ANTIBODIES - A POSSIBLE INVOLVEMENT IN THE DEVELOPMENT OF CHRONIC PERIODONTITIS

2021 ◽  
Vol 68 (2) ◽  
pp. 278-285
Author(s):  
Razvan Circo ◽  
◽  
Marian Beciu ◽  
Doina Raducan ◽  
Victoria Badea ◽  
...  
Keyword(s):  
Serum Level ◽  
Autoimmune Thyroiditis ◽  
Chronic Periodontitis ◽  
Statistical Significance ◽  
Mean Value ◽  
Dental Occlusion ◽  
Thyroid Autoantibodies ◽  
Spontaneous Bleeding ◽  
Chronic Autoimmune Thyroiditis ◽  
Normal Thyroid Function

Objectives. Identification of periodontal lesions in patients with chronic autoimmune thyroiditis (CAT) assessed differently depending on their severity and the average serum level of thyroid autoantibodies. Material and methods. The study was initiated in a group of patients (n = 133) diagnosed with chronic autoimmune thyroiditis in conditions of normal thyroid function and without other comorbidities. Examination of the oral cavity identified lesions characteristic of chronic periodontitis (CP) classified according to their intensity in - mild, medium and aggravated in a group of 109 patients. The serum level of thyroid autoantibodies – as a mean value – was analyzed in a group of 77 patients with similar periodontal lesions related to their classification. Results. Characteristic ethological changes of chronic periodontitis were identified in 85% of patients being classified as: mild (40.2%), medium (31.9%), aggravated (28.5%). Thyroid autoantibodies were present: 62.3% for antithyroperoxidase antibodies (ATPO), 23.8% for both ATPO and antithyroglobulin antibodies (ATG); 13.7% for ATG. The differentiated statistical calculation of the average values of antibodies found for ATPO presented a high statistical significance (p < 0.0002) for spontaneous bleeding, all degrees of tooth mobility, depth of periodontal pockets, root fork and dental occlusion. No statistical significance was found for ATPO in bacterial plaque and gingival regression. No statistical significance was recorded for the mean level of ATG. Conclusions. The correlation of the serum level of thyroid autoantibodies with the specificity of periodontal lesions certify a possible differentiated involvement of them. For ATPO, extra-thyroid systemic effects can be suggested as a priority.

scholarly journals THE EXPERIENCE OF APPLICATION OF COMPLEX FITODRUG CONTAINING POTENTILLA ALBA L. IN PATIENTS WITH CHRONIC AUTOIMMUNE THYROIDITIS

2020 ◽  
Vol 4 (2) ◽  
pp. 83
Author(s):  
M. J. Hotsko ◽  
V. O. Serhiyenko ◽  
I. V. Bobrovych ◽  
R. J. Makarovska ◽  
O. O. Serhiyenko
Keyword(s):  
Autoimmune Thyroiditis ◽  
Chronic Autoimmune Thyroiditis

Expression of TIGIT and FCRL3 is Altered in T Cells from Patients with Distinct Patterns of Chronic Autoimmune Thyroiditis

2018 ◽  
Vol 127 (05) ◽  
pp. 281-288 ◽  
Author(s):  
Mario Štefanić ◽  
Stana Tokić ◽  
Mirjana Suver-Stević ◽  
Ljubica Glavaš-Obrovac
Keyword(s):  
T Cells ◽  
Autoimmune Thyroiditis ◽  
Thyroid Volume ◽  
Thyroid Peroxidase ◽  
Mrna Levels ◽  
Expression Levels ◽  
Chronic Autoimmune Thyroiditis ◽  
End Stage ◽  
Hypothyroid Patients

Abstract Background Co-inhibitory receptors (IR), such as TIGIT and FCRL3, provide a checkpoint against highly destructive immune responses. Co-expression of TIGIT and FCRL3, in particular, has been linked to the HELIOS+ subset of regulatory CD4+FOXP3+T-cells. Of these, CD4+FOXP3-exon(E)2+ cells have higher expression of IR and exhibit strongest suppressive properties. Nevertheless, how the expression of TIGIT, FCRL3, HELIOS, and FOXP3E2 is regulated in chronic autoimmune thyroiditis (AT), is not known. Methods Thirty patients with AT [encompassing spontaneously euthyroid (euAT), hypothyroid-untreated and L-thyroxine-treated cases)] and 10 healthy controls (HC) were recruited. FCRL3, TIGIT, HELIOS and FOXP3E2 mRNA expression levels in peripheral blood (PB) T cells were measured via quantitative real-time PCR and compared to clinicopathological factors. Results The TIGIT and FCRL3 expression levels from T cells of AT cases were inversely related to the thyroid volume, and were significantly increased in hypothyroid patients (on+off L-thyroxine), but not euAT cases. The FCRL3 expression in PB T cells positively correlated with thyroid-peroxidase autoantibody levels; by contrast, T cells from aged AT patients and combined samples (AT+HC) accumulated more TIGIT mRNA. The patients with higher TIGIT mRNA levels had a greater prevalence of hypothyroidism, showing higher peak thyrotropin levels at diagnosis or at follow-up. Conclusions Multiple IR, namely FCRL3 and TIGIT, but not the transcription factors HELIOS and FOXP3E2, showed increased mRNA levels in PB T cells from end-stage, long-standing and/or more aggressive AT, in proportion to disease severity. A relation with major clinical subphenotypes was observed, thereby identifying IR as potentially important players in AT.

Chronic Autoimmune Thyroiditis

2019 ◽  
pp. 379-397
Author(s):  
Andrea Carbone ◽  
Mario Rotondi ◽  
Luca Chiovato
Keyword(s):  
Autoimmune Thyroiditis ◽  
Chronic Autoimmune Thyroiditis

Is chronic autoimmune thyroiditis a systemic disease?

2003 ◽  
Vol 115 (5) ◽  
pp. 412-413 ◽  
Author(s):  
Gherardo Mazziotti ◽  
Giovanni Amato ◽  
Carlo Carella
Keyword(s):  
Autoimmune Thyroiditis ◽  
Systemic Disease ◽  
Chronic Autoimmune Thyroiditis

Different aetiologies in post-partum thyroiditis?

1983 ◽  
Vol 104 (2) ◽  
pp. 195-200 ◽  
Author(s):  
Per Anders Dahlberg ◽  
Rolf Jansson
Keyword(s):  
Thyroid Function ◽  
Autoimmune Thyroiditis ◽  
Thyroid Dysfunction ◽  
Post Partum ◽  
Lymphocytic Infiltration ◽  
Graves Disease ◽  
Thyroid Autoantibodies ◽  
Radioiodine Uptake ◽  
Thyroid Cytology

Abstract. During a 4 year period 19 women with post-partum onset of thyroid dysfunction have been seen in our clinic. Five women had high radioiodine uptake thyrotoxicosis (Graves' disease). Twelve women had hypothyroid symptoms starting within 3–6 months of delivery. All of these women had thyroid microsomal and/or cytoplasmic autoantibodies and thyroid lymphocytic infiltration suggesting aggravation of pre-existing subclinical autoimmune thyroiditis (Hashimoto's disease). At follow-up thyroid function gradually improved in all but signs of persistent thyroid hypofunction remained in seven. Thus women developing symptomatic postpartum hypothyroidism should be followed regularly and when thyroxine treatment is commenced in the post-partum period, it has to be continued indefinitely in many cases. Two women presented with transient low radioiodine uptake thyrotoxicosis and a small painless goitre. Thyroid cytology revealed thyroiditis but they had no thyroid autoantibodies. When followed after a succeeding delivery none of these women developed post-partum thyroid dysfunction in contrast to women in the autoimmune group. Probably the aetiology of thyroid dysfunction in these 2 women was different.

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