scholarly journals ANTITHYROID ANTIBODIES - A POSSIBLE INVOLVEMENT IN THE DEVELOPMENT OF CHRONIC PERIODONTITIS

2021 ◽  
Vol 68 (2) ◽  
pp. 278-285
Author(s):  
Razvan Circo ◽  
◽  
Marian Beciu ◽  
Doina Raducan ◽  
Victoria Badea ◽  
...  
Keyword(s):  
Serum Level ◽  
Autoimmune Thyroiditis ◽  
Chronic Periodontitis ◽  
Statistical Significance ◽  
Mean Value ◽  
Dental Occlusion ◽  
Thyroid Autoantibodies ◽  
Spontaneous Bleeding ◽  
Chronic Autoimmune Thyroiditis ◽  
Normal Thyroid Function

Objectives. Identification of periodontal lesions in patients with chronic autoimmune thyroiditis (CAT) assessed differently depending on their severity and the average serum level of thyroid autoantibodies. Material and methods. The study was initiated in a group of patients (n = 133) diagnosed with chronic autoimmune thyroiditis in conditions of normal thyroid function and without other comorbidities. Examination of the oral cavity identified lesions characteristic of chronic periodontitis (CP) classified according to their intensity in - mild, medium and aggravated in a group of 109 patients. The serum level of thyroid autoantibodies – as a mean value – was analyzed in a group of 77 patients with similar periodontal lesions related to their classification. Results. Characteristic ethological changes of chronic periodontitis were identified in 85% of patients being classified as: mild (40.2%), medium (31.9%), aggravated (28.5%). Thyroid autoantibodies were present: 62.3% for antithyroperoxidase antibodies (ATPO), 23.8% for both ATPO and antithyroglobulin antibodies (ATG); 13.7% for ATG. The differentiated statistical calculation of the average values of antibodies found for ATPO presented a high statistical significance (p < 0.0002) for spontaneous bleeding, all degrees of tooth mobility, depth of periodontal pockets, root fork and dental occlusion. No statistical significance was found for ATPO in bacterial plaque and gingival regression. No statistical significance was recorded for the mean level of ATG. Conclusions. The correlation of the serum level of thyroid autoantibodies with the specificity of periodontal lesions certify a possible differentiated involvement of them. For ATPO, extra-thyroid systemic effects can be suggested as a priority.

scholarly journals Thyroid Autoantibodies in the Cerebrospinal Fluid of Subjects with and without Thyroid Disease: Implications for Hashimoto’s Encephalopathy

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Ioannis Ilias ◽  
Vasiliki Karagiorga ◽  
George Paraskevas ◽  
Anastasia Bougea ◽  
Mara Bourbouli ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Immune System ◽  
Autoimmune Thyroiditis ◽  
Thyroid Disease ◽  
Statistical Significance ◽  
Thyroid Autoantibodies ◽  
Healthy Individuals ◽  
Thyroglobulin Antibodies ◽  
Hashimoto’S Encephalopathy ◽  
Antithyroid Autoantibodies

Introduction. Plasma antithyroid peroxidase (anti-TPO) and anti-thyroglobulin antibodies (anti-Tg) are widely used in the diagnosis of autoimmune thyroiditis. No research has compared anti-TPO and anti-Tg both in plasma and cerebrospinal fluid (CSF) of healthy individuals vis-à-vis patients with thyroid disease.Methods. We measured anti-TPO and anti-Tg antibodies in plasma and CSF in nine subjects (mean age ± SD: 73 ± 6 years) with hypothyroidism and nine subjects (mean age ± SD: 73 ± 8 years) without thyroid disease.Results. The concentration of anti-TPO autoantibodies in CSF was very low compared to plasma in both subjects with thyroid and without thyroid disease (P=0.007). CSF anti-Tg autoantibodies titers were very low compared to the plasma in subjects with thyroid disease (P=0.004), whereas, in subjects without thyroid disease, this difference did not reach statistical significance (P=0.063).Conclusions. Thyroid autoantibodies levels were low in plasma and CSF; we did not observe any transfer of thyroid autoantibodies from the peripheral blood to the CSF. Therefore, regarding Hashimoto’s encephalopathy, where elevated antithyroid autoantibodies are often measured in blood, it is more likely that thyroiditis and encephalopathy represent nonspecific, but distinct, events of an aggressive immune system.

scholarly journals Effects of Selenium Supplementation on Sperm Parameters and DNA-Fragmentation Rate in Patients with Chronic Autoimmune Thyroiditis

2021 ◽  
Vol 10 (16) ◽  
pp. 3755
Author(s):  
Rossella Cannarella ◽  
Rosita A. Condorelli ◽  
Aldo E. Calogero ◽  
Vincenzo Bagnara ◽  
Antonio Aversa ◽  
...  
Keyword(s):  
Dna Fragmentation ◽  
Thyroid Function ◽  
Autoimmune Thyroiditis ◽  
Male Reproduction ◽  
Reproductive Age ◽  
Sperm Parameters ◽  
Lower Percentage ◽  
Normal Thyroid ◽  
Chronic Autoimmune Thyroiditis ◽  
Normal Thyroid Function

Background: Selenium (Se) is an essential component of selenoenzymes, which have catalytic and antioxidant functions. A low Se status has been reported in patients with chronic autoimmune thyroiditis (AT) who benefit from Se supplementation. The role of Se in male reproduction is still a matter of debate. Although Se and selenoenzymes ensure sperm viability and protect against increased oxidative stress, only a few studies have assessed the effects of the administration of Se alone on sperm parameters, providing contrasting results. Aim: The aim of this study was to assess the effects of oral Se supplementation on conventional sperm parameters and DNA fragmentation (SDF) in patients with AT of reproductive age with normal thyroid function. Patients and Methods: Only patients with AT and normal thyroid function were selected for this study. All included patients underwent oral Se supplementation at the dose of 83 µg once daily (Syrel®, IBSA) for six months. Sperm conventional parameters, SDF, and thyroid function were assessed before and at the end of the treatment. Results: Twenty AT patients with normal weight were enrolled. After Se supplementation, they showed a higher sperm concentration, a higher percentage of sperm with progressive motility, and a higher percentage with normal morphology. They also had lower semen leukocyte concentration, and a lower percentage of spermatozoa with DNA fragmentation compared with pre-treatment values. Free-thyroxine serum levels increased significantly, whereas free triiodothyronine showed an upward trend. The thyroid-stimulating hormone did not change significantly. Conclusion: Se supplementation may represent a possible non-hormonal therapeutic choice for the treatment of male infertility, although further studies are needed to confirm this evidence. The possible thyroid hormone dependency of these findings needs to be clarified.

scholarly journals Chronic periodontitis in a group of patients with chronic autoimmune thyroiditis – particularities of expression

2021 ◽  
Vol 68 (1) ◽  
pp. 92-101
Author(s):  
Răzvan Circo ◽  
◽  
Cristina Gosu ◽  
Victoria Badea ◽  
◽  
...  
Keyword(s):  
Linear Regression ◽  
Autoimmune Thyroiditis ◽  
Thyroid Disease ◽  
Statistical Significance ◽  
Statistical Correlation ◽  
Pathological Process ◽  
Periodontal Status ◽  
Autoimmune Thyroid ◽  
Chronic Autoimmune Thyroiditis ◽  
Group 1

Objectives. The intricacy of the inflammatory / infiltrative process common to chronic autoimmune thyroid disease and periodontal disease (CP) justifies the study of the incidence and expression peculiarities of periodontal lesions encountered in patients with chronic autoimmune thyroiditis (CAT). The presence of periodontal plaque correlated with the oral hygiene index represents a proof of the microbial aggression, as a "trigger" in initiating the pathological process with a progressive evolution. Material and method. The study included patients with CP: group 1 – associating CAT, group 2 – without thyroid disease. The periodontal status was assessed: mild, medium, aggravated. Statistically correlated variables: periodontal lesions, sex, age of patients, OHI-s, thyroid functional status (TSH), serum level of thyroid autoantibodies (ATPO / ATg) and antinuclear antibodies (ANA). Results. A heterogeneity of the distribution of periodontal lesions in both groups was found. The preponderance of lesions with statistical significance (p < 0.001) predominated for study group 1. Aggravated periodontal status: more common in group 1 (p = 0.043), was not influenced by the sex of the patients. The monofactorial linear regression finds the average interdependence between the OHI-s value and the age of the patients (r = 0.63; p = 0.018) and the TSH problem (r = 0.55; p = 0.0003). The multifactorial linear regression, however, attests a direct proportional relationship between OHI-s and TSH, ATPO, ATg (r = 0.56; p = 0.001) and intensified with age (r = 0.78, p <0.001). Effect on OHI-s calculated by ANOVA test: ATPO (Pr = 78.66%; r = 0.73; p = 0.05); ATg (Pr = 94.06%; r = 0.73; p = 0.042); both antibodies (Pr = 96.28%, r = 0.87; p = 0.003), correlated with age (r = 0.99; p <0.001). No statistical correlation for ANA was found. Conclusions. The presence and progressive characteristics of CP in patients with CAT attests the etiopathogenic interference of the two diseases and requests an interdisciplinary therapeutic attitude.

scholarly journals Cause of Hypothyroidism in Post Iniversal Salt Iodization era in Nepal

2019 ◽  
Vol 3 (1) ◽  
pp. 10-15
Author(s):  
Sunil Pokharel
Keyword(s):  
Iodine Deficiency ◽  
Autoimmune Thyroiditis ◽  
Subclinical Hypothyroidism ◽  
Hashimoto’S Thyroiditis ◽  
Statistical Significance ◽  
Hashimoto's Thyroiditis ◽  
Female Ratio ◽  
Chronic Autoimmune Thyroiditis ◽  
Salt Iodization ◽  
Iodine Sufficiency

Introduction: Iodine deficiency remains the most common cause of hypothyroidism worldwide, but in areas of iodine sufficiency autoimmune disease (Hashimoto’s thyroiditis) is most common. After implementation of Universal Salt Iodization (USI) to control Iodine Deficiency Disorder(IDD), Nepal is heading towards iodine sufficiency but the prevalence of clinical and subclinical hypothyroidism is still high. So this study was done to find out either chronic autoimmune thyroiditis is the cause of clinical hypothyroidism in post universal salt iodization era of Nepal by measuring Anti-TPO antibody. Method: Newly diagnosed patients with Clinical or Sub clinical hypothyroidism by thyroid function test were included in this study. Anti-TPO antibody was measured by Elisa method, Anti-TPO >34 was considered positive. All the data’s were analyzed using SPSS software. Result: In this study 1000 patients were included, male to female ratio was 5:1. 270 patients had clinical hypothyroidism among which 230(85.1%) patients had Anti-TPO antibody positive. Among 730 patients with subclinical hypothyroidism only 220(30.1%) patients had antibody positive. Our result showed that TPO antibody was positive in clinical hypothyroidism compared to subclinical hypothyroidism with statistical significance (p<0.001). Our result also showed that clinical hypothyroidism had higher TPO value (mean 225.14) compared to subclinical hypothyroidism (74.34) with statistical significance p<0.001. Conclusion: The cause of hypothyroidism in present day Nepal is chronic autoimmune thyroiditis (Hashimoto’s thyroiditis). As we are moving from iodine deficiency status to iodine adequate or iodine excess status there might be an increased burden of thyroid disorders in Nepal due to the increased prevalence of autoimmune thyroiditis.

SERUM THYROTROPHIN AND THE RESPONSE TO THYROTROPHIN RELEASING HORMONE IN SYMPTOMLESS AUTOIMMUNE THYROIDITIS AND IN BORDERLINE AND OVERT HYPOTHYROIDISM

1974 ◽  
Vol 75 (2) ◽  
pp. 274-285 ◽  
Author(s):  
A. Gordin ◽  
P. Saarinen ◽  
R. Pelkonen ◽  
B.-A. Lamberg
Keyword(s):  
Autoimmune Thyroiditis ◽  
Elevated Serum ◽  
Mean Value ◽  
Primary Hypothyroidism ◽  
Overt Hypothyroidism ◽  
Thyrotrophin Releasing Hormone ◽  
Releasing Hormone ◽  
The Mean ◽  
The Individual ◽  
Serum Tsh

ABSTRACT Serum thyrotrophin (TSH) was determined by the double-antibody radioimmunoassay in 58 patients with primary hypothyroidism and was found to be elevated in all but 2 patients, one of whom had overt and one clinically borderline hypothyroidism. Six (29%) out of 21 subjects with symptomless autoimmune thyroiditis (SAT) had an elevated serum TSH level. There was little correlation between the severity of the disease and the serum TSH values in individual cases. However, the mean serum TSH value in overt hypothyroidism (93.4 μU/ml) was significantly higher than the mean value both in clinically borderline hypothyroidism (34.4 μU/ml) and in SAT (8.8 μU/ml). The response to the thyrotrophin-releasing hormone (TRH) was increased in all 39 patients with overt or borderline hypothyroidism and in 9 (43 %) of the 21 subjects with SAT. The individual TRH response in these two groups showed a marked overlap, but the mean response was significantly higher in overt (149.5 μU/ml) or clinically borderline hypothyroidism (99.9 μU/ml) than in SAT (35.3 μU/ml). Thus a normal basal TSH level in connection with a normal response to TRH excludes primary hypothyroidism, but nevertheless not all patients with elevated TSH values or increased responses to TRH are clinically hypothyroid.

The Link between Fingerprints, Genetics & Chronic Periodontitis: A Dermatoglyphic Study

2019 ◽  
Author(s):  
S.S.Sai Karthikeyan
Keyword(s):  
Frequency Distribution ◽  
Chronic Periodontitis ◽  
Statistical Significance ◽  
General Medicine ◽  
Forensic Odontology ◽  
Ridge Count ◽  
Periodontal Tissues ◽  
Inflammatory Conditions ◽  
Chronic Inflammatory Condition ◽  
Fingerprint Pattern

Background: Several methods have been employed for diagnosing inflammatory conditions including biomarkers, enzymes and various other clinical parameters. Dermatoglyphics is one such field which has gained entry in Forensic Medicine, Forensic Odontology and in General Medicine for diagnosing chronic inflammatory conditions. Periodontitis is a chronic inflammatory condition associated with destruction of periodontal tissues. This study aimed to assess the relationship between the fingerprint patterns and chronic periodontitis Methods: A total of 60 patients, belonging to both healthy and chronic periodontitis subjects were assessed by a commercially available fingerprint scanner. All the fingerprint images were assessed for the fingerprint pattern and the ridge count manually. The results were tabulated as percentage frequency distribution for the type of fingerprint pattern. The ridge count is shown as mean ± SD. Unpaired t test was applied to test for statistical significance. Results: The frequency distribution showed equal percentage of Radial Loop type of fingerprint pattern in subjects of both Health and Chronic Periodontitis. Statistical analysis showed Plain Whorl type of fingerprint pattern more significant in subjects having Chronic Periodontitis Conclusion: It was concluded that there might be a relationship between type of fingerprint pattern to the chances of a person having Chronic Periodontitis.

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