scholarly journals The History of Kidney Stone Dissolution Therapy: 50 Years of Optimism and Frustration With Renacidin

2012 ◽  
Vol 26 (2) ◽  
pp. 110-118 ◽  
Author(s):  
Ricardo D. Gonzalez ◽  
Bryant M. Whiting ◽  
Benjamin K. Canales

2020 ◽  
pp. 205141582093688
Author(s):  
Tri Sunu Agung Nugroho ◽  
Ferry Safriadi ◽  
Bambang Sasongko Noegroho

Introduction: Renal pelvic squamous cell carcinoma is a very rare tumor, with a prevalence <1% of all urinary tract tumors, about 0.5–8% of all kidney tumors, and the average age is 50–70 years. Although the incidence of renal squamous cell carcinoma is less common than renal cell carcinoma and renal transitional cell carcinoma, due to its more aggressive nature renal squamous cell carcinoma is often found intraoperatively and is already in an advanced stage or metastasis. The relevant medical history of squamous cell carcinoma is pyelonephritis, chronic nephrolithiasis, and a history of kidney stone surgery. Data which was obtained from previous research at Hasan Sadikin Hospital, from January 2014–December 2017, found the incidence of renal squamous cell carcinoma from nephrectomy procedures was 6%. Methods: This study was a cross-sectional study with a correlative analytic study, samples were taken consecutively from biopsy of kidney mucosa intraoperatively in hospitalized patients with kidney stones with size larger than 20 mm at the Department of Urology, Hasan Sadikin Hospital Bandung, which performed open kidney surgery or percutaneous nephrolithotomy from January–May 2019. Results: The number of samples in this study were from 30 patients, consisting of 16 males and 14 females. Five patients underwent open kidney surgery and 25 patients underwent percutaneous nephrolithotomy surgery, with an average of age of 49.5±11.8 years and 63.3% of patients were aged from 40–60 years. In this study, one patient (3.3%) showed squamous cell carcinoma of the kidney, a 57-year-old male patient with a left staghorn kidney stone who underwent left percutaneous nephrolithotomy surgery. Conclusion: There is a benefit for intraoperative kidney mucosal biopsy as a screening for squamous cell carcinoma of the kidney in nephrolithiasis patients with stones larger than 20 mm. Level of evidence: 3



2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Chien-Heng Chen ◽  
Jia-In Lee ◽  
Jhen-Hao Jhan ◽  
Yung-Chin Lee ◽  
Jiun-Hung Geng ◽  
...  

AbstractResearch indicates smoking increases the risk of various kidney diseases, although the risk of developing kidney stone disease in non-smokers exposed to secondhand smoke is unknown. This study analyzed a total of 19,430 never-smokers with no history of kidney stone disease who participated in the Taiwan Biobank from 2008 to 2019. They were divided into two groups by secondhand smoke exposure; no exposure and exposure groups; the mean age of participants was 51 years, and 81% were women. Incident kidney stone development was observed in 352 (2.0%) and 50 (3.3%) participants in the no exposure and exposure groups during a mean follow-up of 47 months. The odds ratio (OR) of incident kidney stone was significantly higher in the exposure group than the no exposure group [OR, 1.64; 95% confidence interval (95% CI) 1.21 to 2.23]. Participants with > 1.2 h per week exposure were associated with almost twofold risk of developing kidney stones compared with no exposure (OR, 1.92; 95% CI 1.29 to 2.86). Our study suggests that secondhand smoke is a risk factor for development of kidney stones and supports the need for a prospective evaluation of this finding.



2019 ◽  
Vol 33 (5) ◽  
pp. 1404-1412 ◽  
Author(s):  
Mohammad Reza Ardakani Movaghati ◽  
Mahdi Yousefi ◽  
Seyed Ahmad Saghebi ◽  
Mahmoud Sadeghi Vazin ◽  
Aida Iraji ◽  
...  


1924 ◽  
Vol 11 (1) ◽  
pp. 99-104
Author(s):  
Charles E. Barnett
Keyword(s):  


1997 ◽  
Vol 8 (10) ◽  
pp. 1568-1573
Author(s):  
G C Curhan ◽  
W C Willett ◽  
E B Rimm ◽  
M J Stampfer

Kidney stones develop more frequently in individuals with a family history of kidney stones than in those without a family history; however, little information is available regarding whether the increased risk is attributable to genetic factors, environmental exposures, or some combination. In this report, the relation between family history and risk of kidney stone formation was studied in a cohort of 37,999 male participants in the Health Professionals Follow-up Study. Information on family history, kidney stone formation, and other exposures of interest, including dietary intake, was obtained by mailed questionnaires. A family history of kidney stones was much more common in men with a personal history of stones at baseline in 1986 than in those without a history of stones (age-adjusted prevalence odds ratio, 3.16; 95% confidence interval [CI], 2.90 to 3.45). During 8 yr of follow-up, 795 incident cases of stones were documented. After adjusting for a variety of risk factors, the relative risk of incident stone formation in men with a positive family history, compared with those without, was 2.57 (95% CI, 2.19 to 3.02). Family history did not modify the inverse association between dietary calcium intake and the risk of stone formation. These results suggest that a family history of kidney stones substantially increases the risk of stone formation. In addition, these data suggest that dietary calcium restriction may increase the risk of stone formation, even among individuals with a family history of kidney stones.



Author(s):  
Eleanor Brain ◽  
Robert M. Geraghty ◽  
Catherine E. Lovegrove ◽  
Bingyuan Yang ◽  
Bhaskar K. Somani


Author(s):  
Pietro Manuel Ferraro ◽  
Tamara Cunha ◽  
Eric Taylor ◽  
Gary Curhan

Diet is an important contributor to kidney stone formation, but there are limited data regarding long-term changes in dietary factors after a diagnosis of a kidney stone. We analyzed data from three longitudinal cohorts, the Health Professionals Follow-Up Study and the Nurses' Health Studies I and II, comparing changes in dietary factors in participants with and without a history of kidney stones during follow-up. The total daily intake of dietary calcium, supplemental calcium, animal protein, caffeine, fructose, potassium, sodium, oxalate, phytate, vitamin D, vitamin C, sugar-sweetened beverages, fluids, NEAP and DASH score were assessed by repeat FFQs and computed as absolute differences; a difference-in-differences (DID) approach was used to account for general temporal changes using data from participants without a history of kidney stones from the same calendar period. 184,398 participants with no history of kidney stones were included, 7,095 of whom became confirmed stone formers. Several intakes changed significantly over time in stone formers compared with non-formers, with some showing a relative increase up to 8 years later, including caffeine (DID 8.8 mg/day, 95% CI 3.4, 14.1), potassium (23.4 mg/day, 95% CI 4.6, 42.3), phytate (12.1 mg/day, 95% CI 2.5, 21.7), sodium (43.1 mg/day, 95% CI 19.8, 66.5) and fluid intake (47.1 mL/day, 95% CI 22.7, 71.5). Other dietary factors showed a significant decrease, such as oxalate (−7.3 mg/day, 95% CI −11.4, −3.2), vitamin C (−34.2 mg/day, 95% CI −48.8, −19.6), and vitamin D (−18.0 IU/day, 95% CI −27.9, −8.0). A significant reduction in sugar-sweetened beverages of −0.5 (95% CI −0.8, −0.3) and −1.4 (95% CI −1.8, −1.0) servings/week and supplemental calcium −105.1 (95% CI −135.4, −74.7) and −69.4 (95% CI −95.4, −43.4) mg/day for NHS I and NHS II, respectively intake was observed in women. Animal protein, dietary calcium, fructose intake, DASH score and NEAP did not change significantly over time. After the first episode of a kidney stone, mild and inconsistent changes were observed concerning dietary factors associated with kidney stone formation.



2020 ◽  
Vol 6 (1) ◽  
pp. 45-48
Author(s):  
Charlotte Schillebeeckx ◽  
Kathy Vander Eeckt ◽  
Dieter Ost ◽  
Marcel Van den Branden ◽  
Steven Deconinck


BMC Urology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Parvin Khalili ◽  
Zahra Jamali ◽  
Tabandeh Sadeghi ◽  
Ali Esmaeili-nadimi ◽  
Maryam Mohamadi ◽  
...  

Abstract Background The prevalence of kidney stones in the world is increasing and environmental factors seem to play a major role in this issue. The aim of the present study was to investigate the prevalence of risk factors of kidney stones in the adult population of Rafsanjan city based on the data of the Rafsanjan Cohort Study (RCS). Methods In the baseline phase of this study, 10,000 people aged 35 to 70 years are enrolled in the RCS, as one of the prospective epidemiological research studies in Iran. From this population, 9932 participants completed related demographic questionnaires as well as reported a history of diabetes mellitus, kidney stone, and hypertension diseases. The obtained data were analyzed using univariable and multivariable logistics regression. Results According to the obtained results, 46.54% of the studied population were male and 53.46% were female. The mean age of the participants was 49.94 ± 9.56 years. 2392 people accounting for 24.08% of the population had kidney stones. After adjustment of the variables, six variables of gender, WSI, no consumption of purified water, BMI, and history of hypertension and diabetes were found to be significant related factors of kidney stone disease. Conclusions Gender, hypertension, obesity, diabetes, and personal habits like alcohol consumption, opium use and, cigarette smoking are effective in the development of kidney stones. So, by identifying the susceptible patients and teaching them, the burden of the disease on society and the individual can be reduced. The results of this study are helpful to health care providers for preventive planning for kidney stone disease.



2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Cheikh Hassan Hicham Ibrahim ◽  
Maureen Lonergan ◽  
Judy Mullan ◽  
Brendan McAlister ◽  
Kelly Lambert ◽  
...  

Abstract Background and Aims Kidney stones affects 6-9% of the population, with an almost 30% risk of reoccurrence. Factors associated with kidney stone formation include male gender, ethnicity, family history and stone type. The underlying pathology of stone formation is complex and includes increased urine saturation, decreased urine stone inhibitors in addition to metabolic factors. Acute kidney injury (AKI) refers to the abrupt decrease in kidney function, resulting in retention of urea and other waste products and the dysregulation of fluid and electrolyte balance. AKI affects 10-15% of the hospitalised population and is associated with long-term outcomes, such as chronic kidney disease, end-stage kidney disease (ESKD), cardiovascular disease, fractures and earlier mortality. There is evidence that AKI may result in long-term renal damage and fibrosis. A potential effect is impairment in urine concentration which would limit kidney stone formation. However there has been no previous investigation about this potential association. We aim to investigate if there is an association between AKI and kidney stone formation. Method Retrospective clinical data available for all adult (≥18 years of age) hospital admissions to a local health district in Australia between January 2008 and December 2017 was used in the analysis. We excluded 1) non-residents, 2) stone diagnosis pre-AKI, 3) death within 1 month of an AKI episode, 4) dialysis dependent ESKD prior to an AKI episode and 5) incomplete patient information. AKI episode was diagnosed from ICD-10 coding and kidney stone from ICD-10 and SNOMED coding. Our outcome was a kidney stone episode. We examined the entire cohort in addition to propensity score matching (PSM) using 1:1 optimal matching, caliper 0.1 and without replacement based on covariates known to be associated with renal calculi and AKI. Balance before and after PSM was assessed between the groups to evaluate quality using standardised means. Baseline characteristics were compared with chi-square and Mann Whitney U. Multivariate analysis was compared using Logistic regression. Results For the cohort of 180,927 patients, after exclusions, 12,338 (6.8%) patients were diagnosed with an AKI and 4,495 (2.5%) patients with a kidney stone. Patients with an AKI (12,338), compared to patients with no AKI (168,523), were more likely to be older (75.0 vs 50.0 years, p&lt;0.001) with more comorbidities such as hypertension (31.8% vs 12.7%, p&lt;0.001), diabetes (21.5% vs 9.4%, p&lt;0.001), coronary artery disease (14.6% vs 7.0%, p&lt;0.001) and peripheral vascular disease (5.4% vs 1.8%, p&lt;0.001). The risk of kidney stone formation for the entire cohort in patients with a history of AKI was lower when compared to the no AKI patients (1.1% vs 2.6%, Hazard ratio 0.42, 95% confidence interval 0.36- 0.52, p&lt;0.001). After PSM 12,336 patients with AKI were matched with 12,336 patients with no AKI with good balance of covariates. Patients with a history of AKI had a lower risk of kidney stone formation when compared to no AKI patients (Hazard ratio 0.57, 95% Confidence Interval 0.36- 0.51, p&lt;0.001) Conclusion Our findings suggest that patients with AKI appear to be at a significantly lower risk of developing subsequent kidney stone formation when compared to patients with no previous AKI episodes. Further analysis on a greater scale are required to confirm these findings and their implications.



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