Adenovirus-Mediated Herpes Simplex Virus Thymidine Kinase/Ganciclovir Gene Therapy in Patients with Localized Malignancy: Results of a Phase I Clinical Trial in Malignant Mesothelioma

Human Gene Therapy ◽

10.1089/hum.1998.9.7-1083 ◽

1998 ◽

Vol 9 (7) ◽

pp. 1083-1092 ◽

Author(s):

Daniel H. Sterman ◽

Joseph Treat ◽

Leslie A. Litzky ◽

Kunjlata M. Amin ◽

Laura Coonrod ◽

...

Keyword(s):

Clinical Trial ◽

Gene Therapy ◽

Herpes Simplex Virus ◽

Herpes Simplex ◽

Phase I ◽

Thymidine Kinase ◽

Malignant Mesothelioma ◽

Phase I Clinical Trial ◽

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1174. Correlation of Therapeutic Responses with Tumor Associated Parameters: A Phase I Clinical Trial of Adenovirus Osteocalcin Promoter Driven Herpes Simplex Virus Thymidine Kinase (Ad-OC-TK) for Metastatic and Localized Hormone Refractory Prostate Cancer

Molecular Therapy ◽

10.1016/s1525-0016(16)44004-9 ◽

2002 ◽

Vol 5 (5) ◽

pp. S382

Keyword(s):

Prostate Cancer ◽

Clinical Trial ◽

Herpes Simplex Virus ◽

Herpes Simplex ◽

Phase I ◽

Thymidine Kinase ◽

Hormone Refractory Prostate Cancer ◽

Hormone Refractory ◽

Simplex Virus ◽

Therapeutic Responses

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896. Design of a Phase I Clinical Trial for NP2, a Replication Defective Herpes Simplex Virus Type I Viral Vector Expressing Preproenkephalin

Molecular Therapy ◽

10.1016/s1525-0016(16)40299-6 ◽

2008 ◽

Vol 16 ◽

pp. S334

Keyword(s):

Clinical Trial ◽

Herpes Simplex Virus ◽

Herpes Simplex ◽

Phase I ◽

Herpes Simplex Virus Type ◽

Viral Vector ◽

Phase I Clinical Trial ◽

Type I ◽

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A Phase I/II Study of Herpes Simplex Virus Type 1 Thymidine Kinase "Suicide" Gene Therapy for Recurrent Glioblastoma

Human Gene Therapy ◽

10.1089/10430349850019436 ◽

1998 ◽

Vol 9 (17) ◽

pp. 2595-2604 ◽

Author(s):

David Klatzmann ◽

Charles A. Valery ◽

Gilbert Bensimon ◽

Beatrice Marro ◽

Olivier Boyer ◽

...

Keyword(s):

Gene Therapy ◽

Herpes Simplex Virus ◽

Herpes Simplex ◽

Phase I ◽

Thymidine Kinase ◽

Herpes Simplex Virus Type ◽

Suicide Gene ◽

Recurrent Glioblastoma ◽

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A Phase I/II Study of Herpes Simplex Virus Type 1 Thymidine Kinase “Suicide” Gene Therapy for Recurrent Glioblastoma

Human Gene Therapy ◽

10.1089/hum.1998.9.17-2595 ◽

1998 ◽

Vol 9 (17) ◽

pp. 2595-2604 ◽

Author(s):

David Klatzmann ◽

Charles A. Valéry ◽

Gilbert Bensimon ◽

Beatrice Marro ◽

Olivier Boyer ◽

...

Keyword(s):

Gene Therapy ◽

Herpes Simplex Virus ◽

Herpes Simplex ◽

Phase I ◽

Thymidine Kinase ◽

Herpes Simplex Virus Type ◽

Suicide Gene ◽

Recurrent Glioblastoma ◽

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Chronic brain inflammation and persistent herpes simplex virus 1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: Implications for clinical trials

Nature Medicine ◽

10.1038/15207 ◽

1999 ◽

Vol 5 (11) ◽

pp. 1256-1263 ◽

Author(s):

R. A. Dewey ◽

G. Morrissey ◽

C. M. Cowsill ◽

D. Stone ◽

F. Bolognani ◽

...

Keyword(s):

Gene Therapy ◽

Clinical Trials ◽

Herpes Simplex Virus ◽

Herpes Simplex ◽

Thymidine Kinase ◽

Brain Inflammation ◽

Herpes Simplex Virus 1 ◽

Simplex Virus ◽

Kinase Expression

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In vitro thymidine kinase/ganciclovir-based suicide gene therapy using replication defective herpes simplex virus-1 against leukemic B-cell malignancies (MCL, HCL, B-CLL)

Leukemia Research ◽

10.1016/s0145-2126(02)00327-2 ◽

2003 ◽

Vol 27 (8) ◽

pp. 695-699 ◽

Author(s):

Motohiro Misumi ◽

Toshiya Suzuki ◽

Shusuke Moriuchi ◽

Joseph C. Glorioso ◽

Masami Bessho

Keyword(s):

Gene Therapy ◽

Herpes Simplex Virus ◽

Herpes Simplex ◽

B Cell ◽

Thymidine Kinase ◽

Suicide Gene ◽

B Cell Malignancies ◽

Herpes Simplex Virus 1 ◽

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Combination gene therapy of lung cancer with conditionally replicating adenovirus and adenovirus-herpes simplex virus thymidine kinase

International Journal of Molecular Medicine ◽

10.3892/ijmm_00000354 ◽

2010 ◽

Vol 25 (3) ◽

Author(s):

Lee

Keyword(s):

Lung Cancer ◽

Gene Therapy ◽

Herpes Simplex Virus ◽

Herpes Simplex ◽

Thymidine Kinase ◽

Simplex Virus ◽

Conditionally Replicating Adenovirus

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Creation of drug-specific herpes simplex virus type 1 thymidine kinase mutants for gene therapy.

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.93.8.3525 ◽

1996 ◽

Vol 93 (8) ◽

pp. 3525-3529 ◽

Author(s):

M. E. Black ◽

T. G. Newcomb ◽

H. M. Wilson ◽

L. A. Loeb

Keyword(s):

Gene Therapy ◽

Herpes Simplex Virus ◽

Herpes Simplex ◽

Thymidine Kinase ◽

Herpes Simplex Virus Type ◽

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Contribution of a Combination of Ponicidin and Acyclovir/Ganciclovir to the Antitumor Efficacy of the Herpes Simplex Virus Thymidine Kinase Gene Therapy System

Human Gene Therapy ◽

10.1089/10430340252792549 ◽

2002 ◽

Vol 13 (3) ◽

pp. 415-423 ◽

Author(s):

Kyoko Hayashi ◽

Toshimitsu Hayashi ◽

Han-Dong Sun ◽

Yoshio Takeda

Keyword(s):

Gene Therapy ◽

Herpes Simplex Virus ◽

Herpes Simplex ◽

Thymidine Kinase ◽

Antitumor Efficacy ◽

Thymidine Kinase Gene ◽

Kinase Gene ◽

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P-446 Gene therapy for hepatoma cells using a retrovirus vector carrying herpes simplex virus thymidine kinase gene under the control of human ?-fetoprotein gene promoter

International Hepatology Communications ◽

10.1016/0928-4346(95)90741-o ◽

1995 ◽

Vol 3 ◽

pp. S148 ◽

Author(s):

A IDO

Keyword(s):

Gene Therapy ◽

Herpes Simplex Virus ◽

Herpes Simplex ◽

Thymidine Kinase ◽

Gene Promoter ◽

Hepatoma Cells ◽

Thymidine Kinase Gene ◽

Kinase Gene ◽

Retrovirus Vector ◽

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