Effectiveness of Mammography Screening in Reducing Breast Cancer Mortality in Women Aged 39–49 Years: A Meta-Analysis

In 2012, the Euroscreen project published a review of incidence-based mortality evaluations of breast cancer screening programmes. In this paper, we update this review to October 2019 and expand its scope from Europe to worldwide. We carried out a systematic review of incidence-based mortality studies of breast cancer screening programmes, and a meta-analysis of the estimated effects of both invitation to screening and attendance at screening, with adjustment for self-selection bias, on incidence-based mortality from breast cancer. We found 27 valid studies. The results of the meta-analysis showed a significant 22% reduction in breast cancer mortality with invitation to screening, with a relative risk of 0.78 (95% CI 0.75–0.82), and a significant 33% reduction with actual attendance at screening (RR 0.67, 95% CI 0.61–0.75). Breast cancer screening in the routine healthcare setting continues to confer a substantial reduction in mortality from breast cancer.

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Meta Analysis: Effect of Mammography Screening on Breast Cancer Mortality

Journal of Epidemiology and Public Health ◽

10.26911/jepublichealth.2021.06.02.02 ◽

2021 ◽

Vol 6 (2) ◽

pp. 148-157

Author(s):

Bening Rahimi Titisari ◽

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Vitri Widyaningsih ◽

Bhisma Murti ◽

◽

...

Keyword(s):

Breast Cancer ◽

Cancer Mortality ◽

Mammography Screening ◽

Meta Analysis ◽

Breast Cancer Mortality

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Trends in Breast Cancer Mortality in Sweden before and after Implementation of Mammography Screening

PLoS ONE ◽

10.1371/journal.pone.0022422 ◽

2011 ◽

Vol 6 (9) ◽

pp. e22422 ◽

Cited By ~ 16

Author(s):

Jari Haukka ◽

Graham Byrnes ◽

Mathieu Boniol ◽

Philippe Autier

Keyword(s):

Breast Cancer ◽

Cancer Mortality ◽

Mammography Screening ◽

Breast Cancer Mortality ◽

Before And After

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Meta-Analysis Establishes Power of Local Therapies to Lower Breast Cancer Mortality

Oncology Times ◽

10.1097/01.cot.0000287830.78982.41 ◽

2005 ◽

Vol 27 (4) ◽

pp. 30

Author(s):

Rabiya S. Tuma

Keyword(s):

Breast Cancer ◽

Cancer Mortality ◽

Meta Analysis ◽

Breast Cancer Mortality

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Annual mammography screening did not reduce long-term breast cancer mortality in women 40 to 59 years of age

Annals of Internal Medicine ◽

10.7326/0003-4819-160-10-201405200-02007 ◽

2014 ◽

Vol 160 (10) ◽

pp. JC7 ◽

Cited By ~ 3

Author(s):

Suzanne W. Fletcher

Keyword(s):

Breast Cancer ◽

Cancer Mortality ◽

Mammography Screening ◽

Breast Cancer Mortality

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Evaluation of the Effect on Breast Cancer Mortality of Population Based Mammography Screening Programmes

Journal of Medical Screening ◽

10.1177/096914139400100310 ◽

1994 ◽

Vol 1 (3) ◽

pp. 184-187 ◽

Cited By ~ 31

Author(s):

Sven Törnberg ◽

John Carstensen ◽

Timo Hakulinen ◽

Per Lenner ◽

Thomas Hatschek ◽

...

Keyword(s):

Breast Cancer ◽

Cancer Mortality ◽

Mammography Screening ◽

Screening Programme ◽

Breast Cancer Mortality ◽

Time Lag ◽

Statistical Modelling ◽

Population Based ◽

Mortality Data ◽

Full Effect

To evaluate, by analysis of breast cancer mortality data from all the 26 Swedish counties for the years 1971 to 1990, whether the effect of the introduction of mammography screening in Sweden can be assessed by observation from existing mortality data. A Poisson regression model was used to study whether a decrease in breast cancer mortality among women aged 50–74 years was associated with the extent of mammography screening in different counties and periods. In regions where mammography screening had been introduced, breast cancer mortality tended to be decreased, on average, compared with regions with-'out screening. If a 10 year time lag between the start of screening and its full effect on mortality is assumed then the estimated reduction in breast cancer mortality associated with introduction of screening was 19% with a 95% confidence interval ranging from 3% to 37%. The results suggest that the effect of mammography screening may be studied using existing routine mortality data and appropriate statistical modelling. This way of assessing the outcome of the screening is valuable when continuously monitoring a screening programme that has become a public health routine.

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