Effect of Liposome-Mediated Macrophage Depletion on Schwann Cell Proliferation During Wallerian Degeneration

2000 ◽  
Vol 17 (9) ◽  
pp. 789-798 ◽  
Author(s):  
AKIHIKO KUBOTA ◽  
KINUKO SUZUKI
Keyword(s):  
Cell Proliferation ◽  
Schwann Cell ◽  
Wallerian Degeneration ◽  
Macrophage Depletion

scholarly journals Studies of Schwann cell proliferation. I. An analysis in tissue culture of proliferation during development, Wallerian degeneration, and direct injury.

1980 ◽  
Vol 84 (3) ◽  
pp. 739-752 ◽  
Author(s):  
J L Salzer ◽  
R P Bunge
Keyword(s):  
Cell Proliferation ◽  
Tissue Culture ◽  
Schwann Cell ◽  
Schwann Cells ◽  
Wallerian Degeneration ◽  
Variable Response ◽  
Experimental Conditions ◽  
Fetal Rat ◽  
Direct Injury ◽  
Dividing Cells

In this paper the stimuli for and pattern of Schwann cell proliferation are defined under various experimental conditions. We used a tissue culture system in which fetal rat dorsal root ganglia, treated to eliminate contaminating fibroblasts (Wood, P., 1976, Brain Res. 115:361--375), appear to recapitulate many aspects of the developing peripheral nervous system. We observed that: (a) proliferation of Schwann cells on neurites is initially rapid, but, as each neurite becomes fully ensheathed, division slows considerably and is confined to the periphery of the outgrowth; (b) during the period of rapid proliferation, excision of the ganglion causes a rapid decay in the number of dividing cells; (c) excision of the ganglion from more established cultures in which there was little ongoing proliferation resulted in a small increase in labeling at the site of excision for all Schwann cells and a substantial increase in labeling for myelin-related cells with a peak labeling period at 4 d; (d) direct mechanical injury during Wallerian degeneration is mitogenic for Schwann cells; (e) a variety of potential mitogens failed to stimulate Schwann cell proliferation, and (f) replated cells have a slightly higher level of proliferation and show a small and variable response to the addition of cAMP.

Macrophage depletion alters the blood–nerve barrier without affecting Schwann cell function after neural injury

2007 ◽  
Vol 85 (4) ◽  
pp. 766-777 ◽  
Author(s):  
Michael Gray ◽  
Winnie Palispis ◽  
Phillip G. Popovich ◽  
Nico van Rooijen ◽  
Ranjan Gupta
Keyword(s):  
Schwann Cell ◽  
Cell Function ◽  
Neural Injury ◽  
Macrophage Depletion

Is Decorin a Promising New Agent for Facial Nerve Regeneration? An Experimental Study

2021 ◽  
pp. 1-11
Author(s):  
Zehra Çınar ◽  
Ufuk Emre ◽  
Mehmet Gül ◽  
Özgür Yiğit ◽  
Elshan Mammadov ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Schwann Cell ◽  
Facial Nerve ◽  
Axonal Degeneration ◽  
Sham Group ◽  
Axon Diameter ◽  
Compound Muscle Action Potentials ◽  
Before And After ◽  
Potential Benefits ◽  
Group B

Objective: The aim of this study was to investigate the effects of systemic administration of decorin (DC) on facial nerve (FN) regeneration. Methods: A total of 32 female albino Wistar rats were divided into 4 groups: control (C) group: no bilateral FN neurorrhaphy (B-FNN), no DC application, sham-operated group: B-FNN without DC application, DC group: DC application without B-FNN, and B-FNN + DC group: B-FNN and DC application. Nerve conduction studies were performed before and after skin incisions at 1st, 3rd, 5th, and 7th weeks in all groups. The amplitude and latency of compound muscle action potentials were recorded. FN samples were obtained and were investigated under light microscopy and immunohistochemical staining. The nerve and axon diameter, number of axons, H score, Schwann cell proliferation, and myelin and axonal degeneration were recorded quantitatively. Results: In the sham group, the 3rd and 5th postoperative week, amplitude values were significantly lower than those of the B-FNN + DC group (p < 0.05). Nerve diameters were found to be significantly larger in the sham, DC, and B-FNN + DC groups than in the C group (p < 0.05). The number of axons, the axon diameter, and the H scores were found to be significantly higher in the B-FNN + DC group than in the sham group (p < 0.05). The Schwann cell proliferation, myelin degeneration, and axonal degeneration scores were significantly lower in the B-FNN + DC group than in the sham group (p < 0.05). Conclusion: Electrophysiological and histopathological evaluation revealed the potential benefits provided by DC. This agent may increase FN regeneration.

scholarly journals Transcriptional regulation of miR-30a by YAP impacts PTPN13 and KLF9 levels and Schwann cell proliferation

2021 ◽  
pp. 100962
Author(s):  
Alyssa Shepard ◽  
Sany Hoxha ◽  
Scott Troutman ◽  
David Harbaugh ◽  
Michael S. Kareta ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Transcriptional Regulation ◽  
Schwann Cell
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