The Association between Apolipoprotein E and Traumatic Brain Injury Severity and Functional Outcome in a Rehabilitation Sample

2011 ◽  
Vol 28 (9) ◽  
pp. 1683-1692 ◽  
Author(s):  
Jennie Ponsford ◽  
Anna McLaren ◽  
Michael Schönberger ◽  
Richard Burke ◽  
Dion Rudzki ◽  
...  
2021 ◽  
Vol 27 (1) ◽  
pp. 79-86
Author(s):  
Era D. Mikkonen ◽  
Markus B. Skrifvars ◽  
Matti Reinikainen ◽  
Stepani Bendel ◽  
Ruut Laitio ◽  
...  

OBJECTIVETraumatic brain injury (TBI) is a major cause of death and disability in the pediatric population. The authors assessed 1-year costs of intensive care in pediatric TBI patients.METHODSIn this retrospective multicenter cohort study of four academic ICUs in Finland, the authors used the Finnish Intensive Care Consortium database to identify children aged 0–17 years treated for TBI in ICUs between 2003 and 2013. The authors reviewed all patient health records and head CT scans for admission, treatment, and follow-up data. Patient outcomes included functional outcome (favorable outcome defined as a Glasgow Outcome Scale score of 4–5) and death within 6 months. Costs included those for the index hospitalization, rehabilitation, and social security up to 1 year after injury. To assess costs, the authors calculated the effective cost per favorable outcome (ECPFO).RESULTSIn total, 293 patients were included, of whom 61% had moderate to severe TBI (Glasgow Coma Scale [GCS] score 3–12) and 40% were ≥ 13 years of age. Of all patients, 82% had a favorable outcome and 9% died within 6 months of injury. The mean cost per patient was €48,719 ($54,557) (95% CI €41,326–€56,112). The index hospitalization accounted for 66%, rehabilitation costs for 27%, and social security costs for 7% of total healthcare costs. The ECPFO was €59,727 ($66,884) (95% CI €52,335–€67,120). A higher ECPFO was observed among patients with clinical and treatment-related variables indicative of parenchymal swelling and high intracranial pressure. Lower ECPFO was observed among patients with higher admission GCS scores and those who had epidural hematomas.CONCLUSIONSGreater injury severity increases ECPFO and is associated with higher postdischarge costs in pediatric TBI patients. In this pediatric cohort, over two-thirds of all resources were spent on patients with favorable functional outcome, indicating appropriate resource allocation.


1994 ◽  
Vol 75 (3) ◽  
pp. 328-337 ◽  
Author(s):  
Craig M. McDonald ◽  
Kenneth M. Jaffe ◽  
Gayle C. Fay ◽  
Nayak Lincoln Polissar ◽  
Kathleen M. Martin ◽  
...  

Medicine ◽  
2015 ◽  
Vol 94 (46) ◽  
pp. e2028 ◽  
Author(s):  
Lizhuo Li ◽  
Yijun Bao ◽  
Songbai He ◽  
Gang Wang ◽  
Yanlei Guan ◽  
...  

2016 ◽  
Vol 33 (8) ◽  
pp. 721-733 ◽  
Author(s):  
Xiaoting Wang ◽  
Xiang Gao ◽  
Stephanie Michalski ◽  
Shu Zhao ◽  
Jinhui Chen

Sign in / Sign up

Export Citation Format

Share Document