The Spectrum of IgE-Mediated Acute Allergic Reactions to Cow's Milk in Children as Determined by Skin Testing with Cow's Milk Protein Hydrolysate Formulas

1989 ◽  
Vol 3 (4) ◽  
pp. 207-215 ◽  
Author(s):  
ROBERT H. SCHWARTZ ◽  
MARGARET W. KEEFE ◽  
NICK HARRIS ◽  
STEVEN WITHERLY
Keyword(s):  
Milk Protein ◽  
Protein Hydrolysate ◽  
Skin Testing ◽  
Cow’S Milk ◽  
Allergic Reactions ◽  
Cow's Milk ◽  
Ige Mediated ◽  
Cow’S Milk Protein

scholarly journals Fecal Calprotectin and Eosinophil-Derived Neurotoxin in Children with Non-IgE-Mediated Cow’s Milk Protein Allergy

2021 ◽  
Vol 10 (8) ◽  
pp. 1595
Author(s):  
María Roca ◽  
Ester Donat ◽  
Ana Rodriguez Varela ◽  
Eva Carvajal ◽  
Francisco Cano ◽  
...  
Keyword(s):  
Milk Protein ◽  
Statistical Significance ◽  
Functional Gastrointestinal Disorders ◽  
Fecal Calprotectin ◽  
Cow’S Milk ◽  
Cow's Milk ◽  
Young Infants ◽  
Healthy Infants ◽  
Ige Mediated ◽  
Cow’S Milk Protein

Our aim is to assess the efficacy of fecal calprotectin (fCP) and fecal eosinophil-derived neurotoxin (fEDN) as diagnostic markers of cow’s milk protein allergy (CMPA) and for monitoring the infants’ response to a non-IgE mediated cow’s milk protein (CMP)-free diet. We prospectively recruited infants aged 0 to 9 months. Stool samples were taken from 30 infants with CMPA, 19 with mild functional gastrointestinal disorders, 28 healthy infants, and 28 children who presented mild infections. Despite the fact that levels of fCP and fEDN in CMPA infants were higher than in healthy infants at month 0, differences for both parameters did not reach statistical significance (p-value 0.119 and 0.506). After 1 month of an elimination diet, no statistically significant differences in fCP with basal levels were found (p-values 0.184) in the CMPA group. We found a high variability in the fCP and fEDN levels of young infants, and discrepancies in individual behavior of these markers after a CMP-free diet was started. It seems that neither fCP nor fEDN levels are helpful to discriminate between healthy infants and those with signs or symptoms related to non-IgE-mediated CMPA. Additionally, it is debatable if on an individual basis, fCP or fEDN levels could be used for clinical follow-up and dietary compliance monitoring. However, prospective studies with larger populations are needed to draw robust conclusions.

Faecal calprotectin as an aid to the diagnosis of non-IgE mediated cow's milk protein allergy

2016 ◽  
Vol 84 (6) ◽  
pp. 318-323 ◽  
Author(s):  
Carlos Trillo Belizón ◽  
Eduardo Ortega Páez ◽  
Antonio Medina Claros ◽  
Isabel Rodríguez Sánchez ◽  
Ana María Reina González ◽  
...  
Keyword(s):  
Milk Protein ◽  
Cow’S Milk ◽  
Faecal Calprotectin ◽  
Cow's Milk ◽  
Ige Mediated ◽  
Cow’S Milk Protein

scholarly journals ASSESSMENT OF CLINICAL-IMMUNOLOGICAL EFFECTIVENESS OF COMPLEX THERAPY OF INFANT ATOPIC DERMATITIS

2013 ◽  
Vol 10 (5) ◽  
pp. 55-60
Author(s):  
S N Denisova ◽  
T B Sentsova ◽  
M Y Belitskaya
Keyword(s):  
Atopic Dermatitis ◽  
Milk Protein ◽  
Protein Hydrolysate ◽  
Blood Stream ◽  
Diet Therapy ◽  
Cow’S Milk ◽  
Cow's Milk ◽  
Complex Therapy ◽  
Specific Igg ◽  
Cow’S Milk Protein

The work is aimed at assessment of clinicalimmunological effectiveness of diet therapy based on hypoallergenic formula used for infants with atopic dermatitis. 167 infants with atopic dermatitis associated with cow’s milk protein allergy have been put included under outpatient observation. 52 infants of from the first group were being fed on whole goat milk’s formula, 56 infants of from the the second group — cows’ milk protein hydrolysate and 59 infants of the from the third groupsoy’s isolate formula. The age of infants was 2, 5—9 months. The duration of observation was 3—12 months. Complex therapy has been conducted over the infants and it contained antiallergenic treatment and diet therapy with hypoallergenic baby formula. The majority of patients showed improvement due to applied treatment. The first group’s infants with positive clinical dynamic showed decrease of specific IgG and IgE to cow’s milk protein, casein, β-LH and soy’s protein. The infants of the second and third groups also showed decrease of specific IgG and IgE to cow’s milk protein, casein, β-LH, soy’s protein and goat’s milk at clinical remission. All the infants with positive clinical effect showed trend to decrease of IL12, IL13, sICAM1 and sEselectin’s concentration in the blood stream, that can indicate on leukocyte adherence inhibition and cell migration to the area of inflammation. Based on the results of research, we can conclude that replacement of one product with another one by taking into account their clinicalimmunological effectiveness as the method of treatment the of atopic dermatitis patients let us optimize infant diet therapy.

Screening for Cow Milk Allergy Among Young Egyptian Children

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Zeinab A El-Sayed ◽  
Rasha H El-Owaidy ◽  
Hanan M Abd El-Lateef ◽  
Ahmed SA Hammouda
Keyword(s):  
Milk Protein ◽  
Clinical History ◽  
Cow Milk ◽  
Cow’S Milk ◽  
Published Data ◽  
Cow's Milk ◽  
Oral Challenge Test ◽  
Egyptian Children ◽  
Ige Mediated ◽  
Cow’S Milk Protein

Abstract Background There are insufficient published data on the prevalence of cow's milk protein allergy (CMPA) in Egypt. Aim of the Work The study aims to estimate the frequency of CMPA among young Egyptian children in a trial to delineate the magnitude of the problem in our population. Methods A cross-sectional, observational study was conducted on 500 young Egyptian children from the general population aged from 6 months to 5 years; 200 males and 300 females. Children were subjected to history taking and clinical examination. Suspected cases with suggestive clinical history of CMPA were subjected to skin prick test (SPT) with standardized cow’s milk protein allergen extract and open oral challenge test (OCT). Results In the present study, 6.2% of screened children had positive clinical history suggestive of CMPA, 35.5% of them had positive SPT and 51.6% had positive OCT. Based on clinical history and OCT, 3.2% were documented to have CMPA, 3% had undocumented CMPA or low probability of CMPA and 93.8% had no CMPA. The highest rate of initial onset of CMPA is seen before the first year of life (96.8%) and 81.3% of children with positive OCT were formula/mixed-fed. The clinical manifestations in infants with suspected CMPA were variable, and the main presenting feature was gastrointestinal tract manifestations (42%). The IgE-mediated CMPA was more common and constituted 56.3% of the CMPA cases. Conclusion The frequency of CMPA among Egyptian children up to 5 years of age is comparable to the reported frequencies worldwide. IgE-mediated CMPA accounts for more than 2/3 of the patients with proven CMPA in this study.

Patients suffering from non-IgE-mediated cow’s milk protein intolerance cannot be diagnosed based on IgG subclass or IgA responses to milk allergens

Allergy ◽  
2011 ◽  
Vol 66 (9) ◽  
pp. 1201-1207 ◽  
Author(s):  
H. Hochwallner ◽  
U. Schulmeister ◽  
I. Swoboda ◽  
T. E. Twaroch ◽  
H. Vogelsang ◽  
...  
Keyword(s):  
Milk Protein ◽  
Cow’S Milk ◽  
Igg Subclass ◽  
Cow's Milk ◽  
Cow's Milk Protein Intolerance ◽  
Ige Mediated ◽  
Cow’S Milk Protein ◽  
Protein Intolerance
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