Role of Nanofibrous Poly(Caprolactone) Scaffolds in Human Mesenchymal Stem Cell Attachment and Spreading forIn VitroBone Tissue Engineering—Response to Osteogenic Regulators

2010 ◽  
Vol 16 (2) ◽  
pp. 393-404 ◽  
Author(s):  
N.S. Binulal ◽  
M. Deepthy ◽  
N. Selvamurugan ◽  
K.T. Shalumon ◽  
S. Suja ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Cell Attachment ◽  
Human Mesenchymal Stem Cell ◽  
Poly Caprolactone

scholarly journals 3D Printed Wavy Scaffolds Enhance Mesenchymal Stem Cell Osteogenesis

Micromachines ◽  
2019 ◽  
Vol 11 (1) ◽  
pp. 31 ◽  
Author(s):  
Shen Ji ◽  
Murat Guvendiren
Keyword(s):  
Tissue Engineering ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Human Mesenchymal Stem Cell ◽  
Calcium Deposition ◽  
Porous Scaffolds ◽  
Osteogenic Lineage ◽  
3D Printed

There is a growing interest in developing 3D porous scaffolds with tunable architectures for bone tissue engineering. Surface topography has been shown to control stem cell behavior including differentiation. In this study, we printed 3D porous scaffolds with wavy or linear patterns to investigate the effect of wavy scaffold architecture on human mesenchymal stem cell (hMSC) osteogenesis. Five distinct wavy scaffolds were designed using sinusoidal waveforms with varying wavelengths and amplitudes, and orthogonal scaffolds were designed using linear patterns. We found that hMSCs attached to wavy patterns, spread by taking the shape of the curvatures presented by the wavy patterns, exhibited an elongated shape and mature focal adhesion points, and differentiated into the osteogenic lineage. When compared to orthogonal scaffolds, hMSCs on wavy scaffolds showed significantly enhanced osteogenesis, indicated by higher calcium deposition, alkaline phosphatase activity, and osteocalcin staining. This study aids in the development of 3D scaffolds with novel architectures to direct stem osteogenesis for bone tissue engineering.

The role of stiffness of gelatin–hydroxyphenylpropionic acid hydrogels formed by enzyme-mediated crosslinking on the differentiation of human mesenchymal stem cell

Biomaterials ◽  
2010 ◽  
Vol 31 (33) ◽  
pp. 8608-8616 ◽  
Author(s):  
Li-Shan Wang ◽  
Jérôme Boulaire ◽  
Peggy P.Y. Chan ◽  
Joo Eun Chung ◽  
Motoichi Kurisawa
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Human Mesenchymal Stem Cell

Human mesenchymal stem cell implantation and collagen modification as a tool for tissue engineering

2005 ◽  
Vol 28 (4) ◽  
pp. 284-289 ◽  
Author(s):  
M. Markowicz ◽  
A. Heitland ◽  
G. C. M. Steffens ◽  
S. Neuss ◽  
N. Pallua
Keyword(s):  
Tissue Engineering ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Human Mesenchymal Stem Cell ◽  
Cell Implantation
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