Reestablishment of In Vitro and In Vivo Iodide Uptake by Transfection of the Human Sodium Iodide Symporter (hNIS) in a hNIS Defective Human Thyroid Carcinoma Cell Line

Thyroid ◽  
2000 ◽  
Vol 10 (11) ◽  
pp. 939-943 ◽  
Author(s):  
Jan W.A. Smit ◽  
Janny P. Schröder-van der Elst ◽  
Marcel Karperien ◽  
Ivo Que ◽  
Gabri van der Pluijm ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Cell Line ◽  
Sodium Iodide ◽  
Carcinoma Cell ◽  
Human Thyroid ◽  
Sodium Iodide Symporter ◽  
Iodide Uptake ◽  
Thyroid Carcinoma Cell

In Vitro and In Vivo Properties of a Human Anaplastic Thyroid Carcinoma Cell Line Transfected with the Sodium Iodide Symporter Gene

Thyroid ◽  
2004 ◽  
Vol 14 (11) ◽  
pp. 889-895 ◽  
Author(s):  
Yong Jin Lee ◽  
June-Key Chung ◽  
Jae Hoon Shin ◽  
Joo Hyun Kang ◽  
Jae Min Jeong ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Cell Line ◽  
Sodium Iodide ◽  
Carcinoma Cell ◽  
Anaplastic Thyroid Carcinoma ◽  
Carcinoma Cell Line ◽  
Sodium Iodide Symporter ◽  
Thyroid Carcinoma Cell

AZD5153, a novel BRD4 inhibitor, suppresses human thyroid carcinoma cell growth in vitro and in vivo

2018 ◽  
Vol 499 (3) ◽  
pp. 531-537 ◽  
Author(s):  
Kun Xu ◽  
Dexuan Chen ◽  
Dong Qian ◽  
Shihu Zhang ◽  
Yi Zhang ◽  
...  
Keyword(s):  
Cell Growth ◽  
Thyroid Carcinoma ◽  
Carcinoma Cell ◽  
Human Thyroid ◽  
Thyroid Carcinoma Cell

scholarly journals Production of Multiple Growth Factors by a Newly Established Human Thyroid Carcinoma Cell Line

1992 ◽  
Vol 83 (2) ◽  
pp. 153-158 ◽  
Author(s):  
Kaoru Tohyama ◽  
Yataro Yoshida ◽  
Kensaku Ohashi ◽  
Emiko Sano ◽  
Hisataka Kobayashi ◽  
...  
Keyword(s):  
Growth Factors ◽  
Thyroid Carcinoma ◽  
Cell Line ◽  
Carcinoma Cell ◽  
Carcinoma Cell Line ◽  
Human Thyroid ◽  
Thyroid Carcinoma Cell Line ◽  
Thyroid Carcinoma Cell

scholarly journals Thyroid-related hormones as potential markers of hypoxia/ischemia

Human Cell ◽  
2020 ◽  
Vol 33 (3) ◽  
pp. 545-558
Author(s):  
Naoto Tani ◽  
Mayumi Ishikawa ◽  
Miho Watanabe ◽  
Tomoya Ikeda ◽  
Takaki Ishikawa
Keyword(s):  
Head Injury ◽  
Thyroid Carcinoma ◽  
Cell Line ◽  
Carcinoma Cell ◽  
Carcinoma Cell Line ◽  
Human Thyroid ◽  
Systemic Hypoxia ◽  
Hypoxia Ischemia ◽  
Thyroid Carcinoma Cell ◽  
Mechanical Asphyxia

Abstract This study aimed to investigate the usefulness of the thyroid-related hormones as markers of acute systemic hypoxia/ischemia to identify deaths caused by asphyxiation due to neck compression in human autopsy cases. The following deaths from pathophysiological conditions were examined: mechanical asphyxia and acute/subacute blunt head injury; acute/subacute non-head blunt injury; sharp instrument injury as the hemorrhagic shock condition; drowning as alveolar injury; burn; and death due to cardiac dysfunction. Blood samples were collected from the left and right cardiac chambers and iliac veins, and serum triiodothyronine (T3), thyroxine (T4), thyroglobulin (Tg), and thyroid-stimulating hormone (TSH) levels were measured using electrochemiluminescence immunoassays. Two types of thyroid cell lines were used to confirm independent thyroid function under the condition of hypoxia (3% O2). The human thyroid carcinoma cell line (HOTHC) cell line derived from human anaplastic thyroid carcinoma and the UD-PTC (sample of the second resection papillary thyroid carcinoma) cell line derived from human thyroid papillary adenoma, which forms Tg retention follicles, were used to examine the secretion levels of T3, T4, and Tg hormones. The results showed a strong correlation between T3 and T4 levels in all blood sampling sites, while the TSH and Tg levels were not correlated with the other markers. Serum T3 and T4 levels were higher in cases of mechanical asphyxia and acute/subacute blunt head injury, representing hypoxic and ischemic conditions of the brain as compared to those in other causes of death. In the thyroid gland cell line, T4, T3, and Tg levels were stimulated after exposure to hypoxia for 10–30 min. These findings suggest that systemic advanced hypoxia/ischemia may cause a rapid and TSH-independent release of T3 and T4 thyroid hormones in autopsy cases. These findings demonstrate that increased thyroid-related hormone (T3 and T4) levels in the pathophysiological field may indicate systemic hypoxia/ischemia.

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