Screening for Medullary Thyroid Carcinoma with Serum Calcitonin Measurements in Patients with Thyroid Nodules in the United States and Canada

Thyroid ◽  
2011 ◽  
Vol 21 (11) ◽  
pp. 1199-1207 ◽  
Author(s):  
Gilbert H. Daniels
Keyword(s):  
United States ◽  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Thyroid Nodules ◽  
The United States ◽  
Serum Calcitonin ◽  
Medullary Thyroid

scholarly journals Predictive Value of Serum Calcitonin Levels for Preoperative Diagnosis of Medullary Thyroid Carcinoma in a Cohort of 5817 Consecutive Patients with Thyroid Nodules

2006 ◽  
Vol 92 (2) ◽  
pp. 450-455 ◽  
Author(s):  
Giuseppe Costante ◽  
Domenico Meringolo ◽  
Cosimo Durante ◽  
Davide Bianchi ◽  
Maria Nocera ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Predictive Value ◽  
Preoperative Diagnosis ◽  
Thyroid Nodules ◽  
Serum Calcitonin ◽  
Medullary Thyroid

Comparison of serum calcitonin and procalcitonin in detecting medullary thyroid carcinoma among patients with thyroid nodules

2013 ◽  
Vol 51 (7) ◽  
Author(s):  
Luca Giovanella ◽  
Frederik A. Verburg ◽  
Mauro Imperiali ◽  
Stefano Valabrega ◽  
Pierpaolo Trimboli ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Thyroid Nodules ◽  
Serum Calcitonin ◽  
Medullary Thyroid

scholarly journals Replication of newly proposed TNM staging system for medullary thyroid carcinoma: a nationwide study

2019 ◽  
Vol 8 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Jes Sloth Mathiesen ◽  
Jens Peter Kroustrup ◽  
Peter Vestergaard ◽  
Per Løgstrup Poulsen ◽  
Åse Krogh Rasmussen ◽  
...  
Keyword(s):  
United States ◽  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Stage Iv ◽  
Staging System ◽  
The United States ◽  
Population Based ◽  
Tnm Staging ◽  
Medullary Thyroid ◽  
Tnm Staging System

A recent study proposed new TNM groupings for better survival discrimination among stage groups for medullary thyroid carcinoma (MTC) and validated these groupings in a population-based cohort in the United States. However, it is unknown how well the groupings perform in populations outside the United States. Consequently, we conducted the first population-based study aiming to evaluate if the recently proposed TNM groupings provide better survival discrimination than the current American Joint Committee on Cancer (AJCC) TNM staging system (seventh and eighth edition) in a nationwide MTC cohort outside the United States. This retrospective cohort study included 191 patients identified from the nationwide Danish MTC cohort between 1997 and 2014. In multivariate analysis, hazard ratios for overall survival under the current AJCC TNM staging system vs the proposed TNM groupings with stage I as reference were 1.32 (95% CI: 0.38–4.57) vs 3.04 (95% CI: 1.38–6.67) for stage II, 2.06 (95% CI: 0.45–9.39) vs 3.59 (95% CI: 1.61–8.03) for stage III and 5.87 (95% CI: 2.02–17.01) vs 59.26 (20.53–171.02) for stage IV. The newly proposed TNM groupings appear to provide better survival discrimination in the nationwide Danish MTC cohort than the current AJCC TNM staging. Adaption of the proposed TNM groupings by the current AJCC TNM staging system may potentially improve accurateness in survival discrimination. However, before such an adaption further population-based studies securing external validity are needed.

Benefit of measuring basal serum calcitonin to detect medullary thyroid carcinoma in a Danish population with a high prevalence of thyroid nodules

Head & Neck ◽  
2009 ◽  
pp. NA-NA ◽  
Author(s):  
Martin Hasselgren ◽  
Laszlo Hegedüs ◽  
Christian Godballe ◽  
Steen Joop Bonnema
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Thyroid Nodules ◽  
Danish Population ◽  
Serum Calcitonin ◽  
Medullary Thyroid ◽  
Basal Serum ◽  
High Prevalence

scholarly journals Incidental detection of familial medullary thyroid carcinoma by calcitonin screening for nodular thyroid disease

1999 ◽  
pp. 286-289 ◽  
Author(s):  
B Mayr ◽  
G Brabant ◽  
A von zur Muhlen
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Thyroid Disease ◽  
Thyroid Nodules ◽  
Fine Needle Aspiration Biopsy ◽  
Cost Effective ◽  
Needle Aspiration ◽  
Serum Calcitonin ◽  
Medullary Thyroid ◽  
Calcitonin Screening

Serum calcitonin screening has recently been found to be a useful supplement to fine-needle aspiration biopsy, ultrasound and radionuclide imaging in the evaluation of thyroid nodules. We describe a case where introduction of routine calcitonin screening in nodular thyroid disease led to the detection of a family with medullary thyroid carcinoma. The benefits and problems of basal and stimulated serum calcitonin testing and ret-proto-oncogene mutation studies are exemplified and we discuss the appropriate use and interpretation of these tests. We conclude that routine basal serum calcitonin measurement in nodular thyroid disease and thoughtful use of ret-mutation analysis is cost-effective in detecting medullary thyroid carcinoma and multiple endocrine neoplasia type II.

scholarly journals Usefulness of preoperative serum calcitonin in patients with nodular thyroid disease without suspicious history or cytology for medullary thyroid carcinoma

2013 ◽  
Vol 57 (4) ◽  
pp. 312-316 ◽  
Author(s):  
Pedro Weslley Rosário ◽  
Gustavo Cancela Penna ◽  
Kamilla Brandão ◽  
Bárbara Érika Souza
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Multiple Endocrine Neoplasia ◽  
Multiple Endocrine Neoplasia Type ◽  
Serum Calcitonin ◽  
Medullary Thyroid ◽  
Endocrine Neoplasia ◽  
Preoperative Serum ◽  
History Of

OBJECTIVE: To evaluate the usefulness of preoperative serum calcitonin (sCT) in patients with nodular disease without suspicion of medullary thyroid carcinoma (MTC) in history or cytology. PATIENTS AND METHODS: sCT was measured before thyroidectomy in 494 patients with nodular disease who had no family history of MTC or multiple endocrine neoplasia type 2, and no cytological suspicion of MTC. RESULTS: Basal sCT was < 10 ng/mL in 482 patients and none of them had MTC. One patient with basal sCT > 100 pg/mL had MTC. Among the 11 patients with basal sCT between 10 and 100 pg/mL, MTC was diagnosed in only one. The two patients with MTC were submitted to total thyroidectomy, combined with elective lymph node dissection indicated exclusively based on hypercalcitoninemia, and sCT was undetectable after six months. CONCLUSIONS: Preoperative sCT is useful for the detection of sporadic MTC in patients with nodular disease, even in the absence of suspicious history or cytology.

Early Diagnosis and Curative Therapy of Medullary Thyroid Carcinoma by Routine Measurement of Serum Calcitonin in Patients with Thyroid Disorders

Thyroid ◽  
2005 ◽  
Vol 15 (11) ◽  
pp. 1267-1272 ◽  
Author(s):  
H. Vierhapper ◽  
B. Niederle ◽  
C. Bieglmayer ◽  
K. Kaserer ◽  
S. Baumgartner-Parzer
Keyword(s):  
Early Diagnosis ◽  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Thyroid Disorders ◽  
Serum Calcitonin ◽  
Medullary Thyroid ◽  
Curative Therapy ◽  
Routine Measurement
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