Long term persistence of thyrotropin receptor antibodies in wild-type and transgenic mice in a Graves’ disease model

Thyroid ◽  
2012 ◽  
pp. 120410232313002
Author(s):  
Sandra M McLachlan ◽  
Holly Aliesky ◽  
Chun-Rong Chen ◽  
Basil Rapoport
Keyword(s):  
Transgenic Mice ◽  
Disease Model ◽  
Graves Disease ◽  
Thyrotropin Receptor ◽  
Wild Type ◽  
Thyrotropin Receptor Antibodies ◽  
Receptor Antibodies

scholarly journals Role of Self-Tolerance and Chronic Stimulation in the Long-Term Persistence of Adenovirus-Induced Thyrotropin Receptor Antibodies in Wild-Type and Transgenic Mice

Thyroid ◽  
2012 ◽  
Vol 22 (9) ◽  
pp. 931-937 ◽  
Author(s):  
Sandra M. McLachlan ◽  
Holly A. Aliesky ◽  
Chun-Rong Chen ◽  
Basil Rapoport
Keyword(s):  
Transgenic Mice ◽  
Thyrotropin Receptor ◽  
Wild Type ◽  
Chronic Stimulation ◽  
Self Tolerance ◽  
Thyrotropin Receptor Antibodies ◽  
Receptor Antibodies

A cyclic peptide significantly improves thyroid function, thyrotropin-receptor antibodies and orbital mucine /collagen content in a long-term Graves’ disease mouse model

2021 ◽  
Vol 122 ◽  
pp. 102666
Author(s):  
Tanja Diana ◽  
Martin Ungerer ◽  
Christian Wüster ◽  
Julia Faßbender ◽  
Zhongmin Li ◽  
...  
Keyword(s):  
Mouse Model ◽  
Thyroid Function ◽  
Cyclic Peptide ◽  
Collagen Content ◽  
Graves Disease ◽  
Thyrotropin Receptor ◽  
Thyrotropin Receptor Antibodies ◽  
Receptor Antibodies

Prevalence of Thyroid Peroxidase, Thyroglobulin and Thyrotropin Receptor Antibodies in a Long-Term Follow-Up of Juvenile Graves Disease

Autoimmunity ◽  
2000 ◽  
Vol 32 (3) ◽  
pp. 167-172 ◽  
Author(s):  
Lene Lavard ◽  
Hans Perrild ◽  
Bendt Brock Jacobsen ◽  
Mimmi Høier-Madsen ◽  
Giovanna Bendinelli ◽  
...  
Keyword(s):  
Thyroid Peroxidase ◽  
Graves Disease ◽  
Thyrotropin Receptor ◽  
Thyrotropin Receptor Antibodies ◽  
Long Term Follow Up ◽  
Receptor Antibodies

scholarly journals Prospective Trial of Functional Thyrotropin Receptor Antibodies in Graves Disease

2019 ◽  
Vol 105 (4) ◽  
pp. e1006-e1014 ◽  
Author(s):  
George J Kahaly ◽  
Tanja Diana ◽  
Michael Kanitz ◽  
Lara Frommer ◽  
Paul D Olivo
Keyword(s):  
Predictive Value ◽  
Prospective Trial ◽  
Thyroid Stimulating Hormone ◽  
Luciferase Expression ◽  
Graves Disease ◽  
Thyrotropin Receptor ◽  
Tertiary Referral Center ◽  
Thyrotropin Receptor Antibodies ◽  
Receptor Antibodies

Abstract Context Scarce data exist regarding the relevance of stimulatory (TSAb) and blocking (TBAb) thyrotropin receptor antibodies in the management of Graves disease (GD). Objective To evaluate the clinical utility and predictive value of TSAb/TBAb. Design Prospective 2-year trial. Setting Academic tertiary referral center. Patients One hundred consecutive, untreated, hyperthyroid GD patients. Methods TSAb was reported as percentage of specimen-to-reference ratio (SRR) (cutoff SRR < 140%). Blocking activity was defined as percent inhibition of luciferase expression relative to induction with bovine thyrotropin (TSH, thyroid stimulating hormone) alone (cutoff > 40% inhibition). Main Outcome Measures Response versus nonresponse to a 24-week methimazole (MMI) treatment defined as biochemical euthyroidism versus persistent hyperthyroidism at week 24 and/or relapse at weeks 36, 48, and 96. Results Forty-four patients responded to MMI, of whom 43% had Graves orbitopathy (GO), while 56 were nonresponders (66% with GO; P < 0.01). At baseline, undiluted serum TSAb but not thyroid binding inhibitory immunoglobulins (TBII) differentiated between thyroidal GD-only versus GD + GO (P < 0.001). Furthermore, at baseline, responders demonstrated marked differences in diluted TSAb titers compared with nonresponders (P < 0.001). During treatment, serum TSAb levels decreased markedly in responders (P < 0.001) but increased in nonresponders (P < 0.01). In contrast, TBII strongly decreased in nonresponders (P = 0.002). All nonresponders and/or those who relapsed during 72-week follow-up period were TSAb-positive at week 24. A shift from TSAb to TBAb was noted in 8 patients during treatment and/or follow-up and led to remission. Conclusions Serum TSAb levels mirror severity of GD. Their increase during MMI treatment is a marker for ongoing disease activity. TSAb dilution analysis had additional predictive value.

Two Graves' Disease Patients Who Spontaneously Developed Hypothyroidism After Antithyroid Drug Treatment: Characteristics of Epitopes for Thyrotropin Receptor Antibodies

Thyroid ◽  
1999 ◽  
Vol 9 (4) ◽  
pp. 393-399 ◽  
Author(s):  
HYUN-KYUNG CHUNG ◽  
WON BAE KIM ◽  
DO JOON PARK ◽  
LEONARD D. KOHN ◽  
KAZUO TAHARA ◽  
...  
Keyword(s):  
Drug Treatment ◽  
Antithyroid Drug ◽  
Graves Disease ◽  
Thyrotropin Receptor ◽  
Treatment Characteristics ◽  
Thyrotropin Receptor Antibodies ◽  
Antithyroid Drug Treatment ◽  
Receptor Antibodies
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