The Immune System: A Very Short Introduction

Author(s):  
Paul Klenerman

The Immune System: A Very Short Introduction describes the immune system and how it works in health and disease. It focuses on the human immune system, considering how it evolved, and the basic rules that govern its behaviour. The immune system comprises a series of organs, cells, and chemical messengers that work together as a team to provide defence against infection. These components are discussed along with the critical signals that trigger them and how they exert their protective effects, including innate and adaptive responses. The consequences of too little immunity (immunodeficiency), caused for example by HIV/AIDS, and too much, leading to auto-immune and allergic diseases, are also considered.

1995 ◽  
Vol 5 (4) ◽  
pp. 293-310 ◽  
Author(s):  
L. K. Barger ◽  
J. E. Greenleaf ◽  
F. Baldini ◽  
D. Huff

Author(s):  
Tung Bui ◽  
Nguyen Thanh Hai ◽  
Nguyen Thi Huyen ◽  
Tu Thi Thu Hien ◽  
Pham Thi Minh Hue

Biomimetics is a discipline with great potential applications in many aspects of scientific research as well as in daily lives. One of such applications is mimicking the human immune system, a highly complex concept with various components and pathways. From biomimetics of human immunology, scientists have been furthering their knowledge as well as developing numerous products in diagnosing and treating a wide range of diseases.


2013 ◽  
Vol 47 (2) ◽  
pp. 273-281 ◽  
Author(s):  
Ali Kudret ADİLOĞLU ◽  
Nurettin GÖNÜLATEŞ ◽  
Mehmet İŞLER ◽  
Altuğ ŞENOL

2015 ◽  
Vol 2015 ◽  
pp. 1-26 ◽  
Author(s):  
R. Gasparini ◽  
D. Panatto ◽  
N. L. Bragazzi ◽  
P. L. Lai ◽  
A. Bechini ◽  
...  

In the last decades, tremendous advancement in dissecting the mechanisms of pathogenicity ofNeisseria meningitidisat a molecular level has been achieved, exploiting converging approaches of different disciplines, ranging from pathology to microbiology, immunology, and omics sciences (such as genomics and proteomics). Here, we review the molecular biology of the infectious agent and, in particular, its interactions with the immune system, focusing on both the innate and the adaptive responses. Meningococci exploit different mechanisms and complex machineries in order to subvert the immune system and to avoid being killed. Capsular polysaccharide and lipooligosaccharide glycan composition, in particular, play a major role in circumventing immune response. The understanding of these mechanisms has opened new horizons in the field of vaccinology. Nowadays different licensed meningococcal vaccines are available and used: conjugate meningococcal C vaccines, tetravalent conjugate vaccines, an affordable conjugate vaccine against theN. menigitidisserogroup A, and universal vaccines based on multiple antigens each one with a different and peculiar function against meningococcal group B strains.


2010 ◽  
Vol 47 (11-12) ◽  
pp. 1943-1955 ◽  
Author(s):  
Kirstin M. Heutinck ◽  
Ineke J.M. ten Berge ◽  
C. Erik Hack ◽  
Jörg Hamann ◽  
Ajda T. Rowshani

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