scholarly journals Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification

2007 ◽  
Vol 85 (1) ◽  
pp. 193-200 ◽  
Author(s):  
Martha Savaria Morris ◽  
Paul F Jacques ◽  
Irwin H Rosenberg ◽  
Jacob Selhub
Keyword(s):  
Cognitive Impairment ◽  
Folic Acid ◽  
Vitamin B ◽  
Older Americans ◽  
Folic Acid Fortification ◽  
Vitamin B 12

scholarly journals Low vitamin B-12 concentrations in patients without anemia: the effect of folic acid fortification of grain

2003 ◽  
Vol 77 (6) ◽  
pp. 1474-1477 ◽  
Author(s):  
James L Mills ◽  
Isabelle Von Kohorn ◽  
Mary R Conley ◽  
Jack A Zeller ◽  
Christopher Cox ◽  
...  
Keyword(s):  
Folic Acid ◽  
Vitamin B ◽  
Folic Acid Fortification ◽  
Vitamin B 12

scholarly journals Interactions between plasma concentrations of folate and markers of vitamin B12status with cognitive performance in elderly people not exposed to folic acid fortification: the Hordaland Health Study

2013 ◽  
Vol 111 (6) ◽  
pp. 1085-1095 ◽  
Author(s):  
Esmée L. Doets ◽  
Per M. Ueland ◽  
Grethe S. Tell ◽  
Stein Emil Vollset ◽  
Ottar K. Nygård ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Folic Acid ◽  
Cognitive Performance ◽  
Sex Education ◽  
Plasma Concentrations ◽  
Health Study ◽  
Vitamin B ◽  
Plasma Vitamin ◽  
Folic Acid Fortification ◽  
Plasma Folate

A combination of high folate with low vitamin B12plasma status has been associated with cognitive impairment in a population exposed to mandatory folic acid fortification. The objective of the present study was to examine the interactions between plasma concentrations of folate and vitamin B12markers in relation to cognitive performance in Norwegian elderly who were unexposed to mandatory or voluntary folic acid fortification. Cognitive performance was assessed by six cognitive tests in 2203 individuals aged 72–74 years. A combined score was calculated using principal component analysis. The associations of folate concentrations, vitamin B12markers (total vitamin B12, holotranscobalamin (holoTC) and methylmalonic acid (MMA)) and their interactions in relation to cognitive performance were evaluated by quantile regression and least-squares regression, adjusted for sex, education, apo-ɛ4 genotype, history of CVD/hypertension and creatinine. Cross-sectional analyses revealed an interaction (P= 0·009) between plasma concentrations of folate and vitamin B12in relation to cognitive performance. Plasma vitamin B12concentrations in the lowest quartile ( < 274 pmol/l) combined with plasma folate concentrations in the highest quartile (>18·5 nmol/l) were associated with a reduced risk of cognitive impairment compared with plasma concentrations in the middle quartiles of both vitamins (OR 0·22, 95 % CI 0·05, 0·92). The interaction between folate and holoTC or MMA in relation to cognitive performance was not significant. In conclusion, this large study population unexposed to mandatory folic acid fortification showed that plasma folate, but not plasma vitamin B12, was associated with cognitive performance. Among the elderly participants with vitamin B12concentrations in the lower range, the association between plasma folate and cognitive performance was strongest.

scholarly journals Folate and vitamin B12status in relation to cognitive impairment and anaemia in the setting of voluntary fortification in the UK

2008 ◽  
Vol 100 (5) ◽  
pp. 1054-1059 ◽  
Author(s):  
Robert Clarke ◽  
Paul Sherliker ◽  
Harold Hin ◽  
Anne M. Molloy ◽  
Ebba Nexo ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Folic Acid ◽  
Older People ◽  
Serum Folate ◽  
Vitamin B ◽  
Cross Sectional ◽  
Folic Acid Fortification ◽  
Folate Status ◽  
Cross Sectional Studies ◽  
The Uk

Concerns about risks for older people with vitamin B12deficiency have delayed the introduction of mandatory folic acid fortification in the UK. We examined the risks of anaemia and cognitive impairment in older people with low B12and high folate status in the setting of voluntary fortification in the UK. Data were obtained from two cross-sectional studies (n2403) conducted in Oxford city and Banbury in 1995 and 2003, respectively. Associations (OR and 95 % CI) of cognitive impairment and of anaemia with low B12status (holotranscobalamin < 45 pmol/l) with or without high folate status (defined either as serum folate >30 nmol/l or >60 nmol/l) were estimated after adjustment for age, sex, smoking and study. Mean serum folate levels increased from 15·8 (sd14·7) nmol/l in 1995 to 31·1 (sd26·2) nmol/l in 2003. Serum folate levels were greater than 30 nmol/l in 9 % and greater than 60 nmol/l in 5 %. The association of cognitive impairment with low B12status was unaffected by highv.low folate status (>30 nmol/l) (OR 1·50 (95 % CI 0·91, 2·46)v.1·45 (95 % CI 1·19, 1·76)), respectively. The associations of cognitive impairment with low B12status were also similar using the higher cut-off point of 60 nmol/l for folate status ((OR 2·46; 95 % CI 0·90, 6·71)v.(1·56; 95 % CI 1·30, 1·88)). There was no evidence of modification by high folate status of the associations of low B12with anaemia or cognitive impairment in the setting of voluntary fortification, but periodic surveys are needed to monitor fortification.

scholarly journals Cognitive impairment in older Americans in the age of folic acid fortification

2007 ◽  
Vol 86 (1) ◽  
pp. 265-267 ◽  
Author(s):  
Robert J Berry ◽  
Heather K Carter ◽  
Quanhe Yang
Keyword(s):  
Cognitive Impairment ◽  
Folic Acid ◽  
Older Americans ◽  
Folic Acid Fortification

scholarly journals The Chilean Flour Folic Acid Fortification Program Reduces Serum Homocysteine Levels and Masks Vitamin B-12 Deficiency in Elderly People

2002 ◽  
Vol 132 (2) ◽  
pp. 289-291 ◽  
Author(s):  
Sandra Hirsch ◽  
Pía de la Maza ◽  
Gladys Barrera ◽  
Vivian Gattás ◽  
Margarita Petermann ◽  
...  
Keyword(s):  
Folic Acid ◽  
Elderly People ◽  
Vitamin B ◽  
Folic Acid Fortification ◽  
Serum Homocysteine ◽  
Vitamin B 12
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