scholarly journals Modeling the impact of folic acid fortification and supplementation on red blood cell folate concentrations and predicted neural tube defect risk in the United States: have we reached optimal prevention?

2018 ◽  
Vol 107 (6) ◽  
pp. 1027-1034 ◽  
Author(s):  
Krista S Crider ◽  
Yan Ping Qi ◽  
Owen Devine ◽  
Sarah C Tinker ◽  
Robert J Berry
Keyword(s):  
United States ◽  
Folic Acid ◽  
Blood Cell ◽  
Neural Tube ◽  
Neural Tube Defect ◽  
Red Blood Cell ◽  
The United States ◽  
Folic Acid Fortification ◽  
The Impact

scholarly journals Neural Tube Defects and Maternal Folate Intake Among Pregnancies Conceived After Folic Acid Fortification in the United States

2008 ◽  
Vol 169 (1) ◽  
pp. 9-17 ◽  
Author(s):  
B. S. Mosley ◽  
M. A. Cleves ◽  
A. M. Siega-Riz ◽  
G. M. Shaw ◽  
M. A. Canfield ◽  
...  
Keyword(s):  
United States ◽  
Folic Acid ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
The United States ◽  
Folate Intake ◽  
Folic Acid Fortification

Diminished Need for Folate Measurements Among Indigent Populations in the Post Folic Acid Supplementation Era

2007 ◽  
Vol 131 (3) ◽  
pp. 477-480
Author(s):  
Dean W. Joelson ◽  
Eberhard W. Fiebig ◽  
Alan H. B. Wu
Keyword(s):  
United States ◽  
Folic Acid ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Rare Event ◽  
Folate Deficiency ◽  
The United States ◽  
Folic Acid Supplementation ◽  
Folate Concentration ◽  
Using Data

Abstract Context.—The mandated fortification of processed grains with folic acid in the United States and Canada in 1998 was intended to reduce the incidence of neural tube defects in pregnant women. The incidence of folate deficiency in most populations has declined dramatically since then. Objective.—To determine the rate of folate deficiency in a cohort of indigent patients, a population among those at highest risk for folate deficiency. Design.—Using data from 3 years (1997, 2000, and 2004), we examined results of laboratory tests for red blood cell folate ordered at 3 hospitals that predominately service the needs of indigent patients. Folate concentration cutoffs were 160 ng/mL (363.6 nmol/L) and 94 ng/mL (213 nmol/L). Results.—Using a red blood cell folate cutoff concentration of 160 ng/mL (363.6 nmol/L), the combined incidence of folate deficiency decreased from 4.8% in 1997 to 0.6% in 2004. At a cutoff of 94 ng/mL (213 nmol/L), the incidence went from 0.98% to 0.09% in 1997 and 2004, respectively. Even when the folate concentration was found to be low, the majority of these subjects did not have macrocytosis. Conclusions.—These data suggest that folate deficiency has become a rare event in the United States, and the utility of routine folate measurements for patients with anemia and/or increased mean corpuscular volume are difficult to justify.

Vitamin B12 deficiency is the dominant nutritional cause of hyperhomocysteinemia in a folic acid-fortified population

2005 ◽  
Vol 43 (10) ◽  
Author(s):  
Ralph Green ◽  
Joshua W. Miller
Keyword(s):  
United States ◽  
Folic Acid ◽  
Vitamin B12 Deficiency ◽  
The United States ◽  
Community Dwelling ◽  
Vitamin B ◽  
Prevalence Rates ◽  
Total Vitamin ◽  
Folic Acid Fortification ◽  
B12 Deficiency

AbstractPrevalence rates for folate deficiency and hyperhomocysteinemia have been markedly reduced following the introduction of folic acid fortification in the United States. We report the prevalence of hyperhomocysteinemia in a population of community-dwelling elderly Latinos in the post-folic acid fortification era. We measured homocysteine, total vitamin B

scholarly journals Trends in age and red blood cell donation habits among several racial/ethnic minority groups in the United States

Transfusion ◽  
2017 ◽  
Vol 57 (7) ◽  
pp. 1644-1655 ◽  
Author(s):  
Mark H. Yazer ◽  
Ralph Vassallo ◽  
Meghan Delaney ◽  
Marc Germain ◽  
Matthew S. Karafin ◽  
...  
Keyword(s):  
United States ◽  
Blood Cell ◽  
Ethnic Minority ◽  
Red Blood Cell ◽  
Minority Groups ◽  
The United States ◽  
Ethnic Minority Groups ◽  
Racial Ethnic

Impact of Folic Acid Fortification in the United States

2004 ◽  
Vol 104 (1) ◽  
pp. 197 ◽  
Author(s):  
Mark I. Evans ◽  
Elisa Llurba ◽  
Ellen J. Landsberger
Keyword(s):  
United States ◽  
Folic Acid ◽  
The United States ◽  
Folic Acid Fortification
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