scholarly journals Predicting the Impact of Folic Acid Fortification, Ready to Eat Cereals and Supplement Use on the Risk of Neural Tube Defects in the United States

2015 ◽  
Vol 29 (S1) ◽  
Author(s):  
Krista Crider ◽  
Owen Devine ◽  
Yan Qi ◽  
Sarah Tinker ◽  
R Berry
Keyword(s):  
United States ◽  
Folic Acid ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
The United States ◽  
Folic Acid Fortification ◽  
Supplement Use ◽  
The Impact

scholarly journals Neural Tube Defects and Maternal Folate Intake Among Pregnancies Conceived After Folic Acid Fortification in the United States

2008 ◽  
Vol 169 (1) ◽  
pp. 9-17 ◽  
Author(s):  
B. S. Mosley ◽  
M. A. Cleves ◽  
A. M. Siega-Riz ◽  
G. M. Shaw ◽  
M. A. Canfield ◽  
...  
Keyword(s):  
United States ◽  
Folic Acid ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
The United States ◽  
Folate Intake ◽  
Folic Acid Fortification

scholarly journals Impact of folic acid fortification of flour on neural tube defects: a systematic review

2012 ◽  
Vol 16 (5) ◽  
pp. 901-911 ◽  
Author(s):  
Cecilia Castillo-Lancellotti ◽  
Josep A Tur ◽  
Ricardo Uauy
Keyword(s):  
Systematic Review ◽  
Folic Acid ◽  
Costa Rica ◽  
Latin American ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Folic Acid Fortification ◽  
Potential Association ◽  
The Usa ◽  
The Impact

AbstractObjectiveTo review the impact of folic acid fortification of flour on the prevalence of neural tube defects (NTD).DesignSystematic review of the literature on MEDLINE via PubMed, Scopus, OvidSP and LILACS (Latin American and Caribbean Health Sciences Literature) reporting the impact of folic acid fortification of flour on the prevalence of NTD in 2000–2011. Focusing on Santiago of Chile's birth defects registry (1999–2009) and the monitoring of flour fortification, we analysed the prevalence (NTD cases/10 000 births) pre and post flour fortification and the percentile distribution of folic acid content in flour (2005–2009). We explored the potential association between median folic acid in flour (mg/kg) and the prevalence of NTD.SettingChile, Argentina, Brazil, Canada, Costa Rica, Iran, Jordan, South Africa and the USA.SubjectsLive births and stillbirths.ResultsTwenty-seven studies that met inclusion criteria were evaluated. Costa Rica showed a significant reduction in NTD (∼60 %). Prevalence in Chile decreased from 18·6 to 7·3/10 000 births from 1999 to 2007 and showed a slight increase to 8·5 in 2008–2009, possibly due to changes in fortification limits. When we related the prevalence of NTD with levels of flour fortification, the lowest prevalence was observed at a folic acid level of 1·5 mg/kg.ConclusionsFortification of flour with folic acid has had a major impact on NTD in all countries where this has been reported. Chile showed a 55 % reduction in NTD prevalence between 1999 and 2009. There is a need to constantly monitor the levels of flour fortification to maximize benefits and prevent the potential risk of folic acid excess, moreover to be vigilant for any new adverse effects associated with excess.

scholarly journals Predicting the Impact of Mandatory Folic Acid Fortification on Neural Tube Defects in New Zealand

Proceedings ◽  
2019 ◽  
Vol 37 (1) ◽  
pp. 17
Author(s):  
Michelle Gibbs ◽  
Rebecca Doonan ◽  
Peter van der Logt ◽  
Julie Boorman
Keyword(s):  
Folic Acid ◽  
New Zealand ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Compelling Evidence ◽  
Folic Acid Fortification ◽  
The Impact

Background: There is compelling evidence that mandatory fortification of food with folic acid reduces the prevalence of neural tube defects (NTDs).[...]

scholarly journals Perspective: Time to Resolve Confusion on Folate Amounts, Units, and Forms in Prenatal Supplements

2020 ◽  
Vol 11 (4) ◽  
pp. 753-759 ◽  
Author(s):  
Leila G Saldanha ◽  
Johanna T Dwyer ◽  
Carol J Haggans ◽  
James L Mills ◽  
Nancy Potischman
Keyword(s):  
United States ◽  
Folic Acid ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
The United States ◽  
Chemical Forms ◽  
Dietary Folate ◽  
Intake Level

ABSTRACT Folate-containing prenatal supplements are commonly consumed in the United States, but inconsistencies in units of measure and chemical forms pose challenges for providing authoritative advice on recommended amounts. New regulations require folate to be declared as micrograms of dietary folate equivalents (DFE) on product labels, whereas intake recommendations for reducing the risk of neural tube defects (NTDs) and the Tolerable Upper Intake Level are expressed as micrograms of folic acid. Today, >25% of prenatal supplements contain folate as synthetic salts of L-5-methyltetrahydrofolate (L-5-MTHF), but recommendations do not include this form of the vitamin. Harmonizing units of measure and addressing newer forms of folate salts in intake recommendations and in the prevention of NTDs would resolve the confusion.

Vitamins, folic acid and neural tube defects: Comments on investigations in the United States

1991 ◽  
Vol 11 (8) ◽  
pp. 641-648 ◽  
Author(s):  
Joe Leigh Simpson ◽  
James L. Mills ◽  
George G. Rhoads ◽  
George C. Cunningham ◽  
Howard J. Hoffman ◽  
...  
Keyword(s):  
United States ◽  
Folic Acid ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
The United States
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