85 Fine Needle Aspiration of a Hürthle Cell Adenoma With Atypical Features: A Case Study and Diagnostic Dilemma

Abstract Context.—Cytoplasmic yellow bodies are a common and frequent histologic finding in hyalinizing trabecular adenoma of the thyroid gland, a morphologically distinctive neoplasm, and are visible in fine-needle aspiration biopsy of the tumor. Objective.—To determine the prevalence and frequency of cytoplasmic yellow bodies in common thyroid tumors. Design.—Microscopic slides of random cases of papillary carcinoma (61 cases), follicular adenoma (27 cases), and Hürthle cell adenoma (12 cases) were searched for cytoplasmic yellow bodies. Setting and Patients.—Slides were from patients who had undergone surgery at Mayo Clinic, Rochester, Minn, and were obtained from the Mayo Clinic Tissue Registry. Main Outcome Measure.—Presence or absence of cytoplasmic yellow bodies. Results.—Cytoplasmic yellow bodies were found in papillary carcinoma (62%), follicular carcinoma (22%), and Hürthle cell adenoma (83%) but were very infrequent numerically in each tumor type. Conclusions.—Cytoplasmic yellow bodies may be present in papillary carcinoma and in follicular and Hürthle cell adenomas, but because they are uncommon in these tumors, they are unlikely to be found in fine-needle aspiration biopsy smears. Therefore, cytoplasmic yellow bodies are a useful cytomorphologic indicator of hyalinizing trabecular adenoma of the thyroid gland.

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Fine Needle Aspiration: who must perform this Procedure?

Archives of Medical Case Reports and Case Study ◽

10.31579/2692-9392/079 ◽

2021 ◽

Vol 4 (5) ◽

pp. 01-05

Author(s):

Negri Stefano ◽

Azzolini Diana ◽

Corradi Gabriele ◽

Calabrese Giovanni

Keyword(s):

Fine Needle Aspiration ◽

Needle Aspiration ◽

The Body ◽

Diagnostic Quality ◽

Fine Needle ◽

Pathologic Anatomy ◽

Historical Moment

In this historical moment, when FNA seems to have lost its paramount importance, it’s necessary to publish the data of the case study carried out from 2007 to 2014 in the pathologic anatomy unit at Carlo Poma Hospital in Mantua. This work includes 5,586 FNAs performed in various parts of the body. In particular, we examined 583 breast FNAs performed by a pathologist without help from a radiologist. The data confirm that it is very important for a pathologist to be present when a sample is being taken as this results in a decrease in the number of inadequate preparations as well as in improved diagnostic quality.

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Fine-needle aspiration cytology of basal cell adenoma of the parotid gland: Characteristic cytological features and diagnostic pitfalls

Diagnostic Cytopathology ◽

10.1002/dc.20598 ◽

2007 ◽

Vol 35 (2) ◽

pp. 85-90 ◽

Cited By ~ 24

Author(s):

Akihiko Kawahara ◽

Hiroshi Harada ◽

Jun Akiba ◽

Toshiro Yokoyama ◽

Masayoshi Kage

Keyword(s):

Parotid Gland ◽

Fine Needle Aspiration ◽

Needle Aspiration ◽

Basal Cell Adenoma ◽

Aspiration Cytology ◽

Cell Adenoma ◽

Fine Needle ◽

Cytological Features ◽

Needle Aspiration Cytology ◽

Diagnostic Pitfalls

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Clinical Outcomes for “Suspicious” Category in Thyroid Fine-Needle Aspiration Biopsy: Patient's Sex and Nodule Size Are Possible Predictors of Malignancy

Archives of Pathology & Laboratory Medicine ◽

10.5858/133.5.787 ◽

2009 ◽

Vol 133 (5) ◽

pp. 787-790

Author(s):

Kirtee Raparia ◽

Soo Kee Min ◽

Dina R. Mody ◽

Rose Anton ◽

Mojgan Amrikachi

Keyword(s):

Surgical Resection ◽

Fine Needle Aspiration ◽

Needle Aspiration ◽

Cytologic Diagnosis ◽

Fine Needle ◽

Female Patients ◽

Hürthle Cell ◽

Significant Difference ◽

Cell Neoplasm ◽

Male Patients

Abstract Context.—Fine-needle aspiration (FNA) is recommended as an initial screening tool for the diagnosis of thyroid nodules. Approximately 10% of thyroid FNA diagnoses are “suspicious for neoplasm,” warranting surgical resection. Objectives.—To examine the role of a patient's age, sex, size of nodule, and morphologic features as possible predictors of malignancy in patients with cytologic diagnosis of “suspicious for neoplasm.” Design.—Cytopathology slides and reports of 402 consecutive thyroid FNAs from 2000–2005 interpreted as “suspicious” were reviewed. Of these, 180 cases that had subsequent surgical resection were selected. Results.—Of the 108 cases suspicious for follicular neoplasm on cytologic evaluation, histologic follow-up showed malignancy in 26 (24%). Of the 37 cases suspicious for Hürthle cell neoplasm, 15 (41%) had malignancy. Of the 35 cases suspicious for malignancy, 29 had malignant histologic diagnoses. Among cases with cytologic diagnoses of “suspicious for follicular or Hürthle cell neoplasm,” the rate of malignancy in female patients was 22% as compared to 43% in male patients (P = .02). The rate of malignancy in nodules less than 2 cm was 19% compared to 47% in nodules measuring 2 cm or larger (P < .001). These differences were statistically significant. No statistically significant difference was noted between the age of the patient and the rate of benign versus malignant diagnosis. Conclusions.—Malignant tumors were more frequent in male patients with a cytologic diagnosis of “suspicious for follicular or Hürthle cell neoplasm” than in female patients. Risk of malignancy was higher in nodules measuring 2 cm or larger. Age of the patient was not a predictor of malignancy.

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