Seasonal Influenza Vaccination Coverage Among Adult Populations in the United States, 2005-2011

Abstract Background Pertussis and seasonal influenza are responsible for significant maternal, neonatal, and infant morbidity and mortality, but vaccine coverage rates (VCR) for both pertussis (administered as a tetanus, diphtheria, acellular pertussis [Tdap] vaccination) and seasonal influenza in pregnancy remain generally low. Only a small number of countries, including Spain, the United Kingdom (UK), and the United States (US), have high Tdap and seasonal influenza VCRs in pregnancy. The purpose of this study was to identify the key factors that contributed to the high VCRs observed in these countries. Methods The experience from both Tdap and seasonal influenza vaccination programmes during pregnancy were documented in Spain, the UK, and the US using a three-step approach. A literature review yielded 157 publications, and a further 117 documents were selected through desk research. A published five-pillar VCR framework for influenza was amended to evaluate the specific contributing factors leading to high Tdap and seasonal influenza VCRs among pregnant women. Results The analysis identified components that contributed to higher VCR in pregnant women across three different healthcare systems in Spain, UK, and US. The combination of several key interventions in each country led to a rapid increase in VCR that reached near-optimal levels (i.e. 75% for seasonal influenza) within a few years. As well as inclusion in national immunisation programme and vaccine reimbursement, key components that were identified included the mobilisation of health authorities, prenatal care Healthcare Professionals (HCP) and scientific societies, the inclusion of vaccination in antenatal medical guidance, the provision of educational material to HCPs, and a strong disease awareness driven by recent pertussis outbreaks in each country. Conclusions Although there is no simple, universal solution to improving sub-optimal VCRs, the list of components identified in this study from three countries with high-performing Tdap and seasonal influenza vaccination programmes provides a basis for public health and medical stakeholders in other countries to define strategies to successfully implement national vaccination programmes for pregnant women.

Download Full-text

Faculty Opinions recommendation of Effect of expanded US recommendations for seasonal influenza vaccination: comparison of two pediatric emergency departments in the United States and Canada.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.13352978.14724083 ◽

2011 ◽

Author(s):

George Petrikkos ◽

Sotirios Tsiodras

Keyword(s):

United States ◽

Influenza Vaccination ◽

Emergency Departments ◽

Seasonal Influenza ◽

The United States ◽

Pediatric Emergency ◽

Seasonal Influenza Vaccination

Download Full-text

2742. The Impact of Influenza Vaccination on Antibiotic Use in the United States, 2010–2017

Open Forum Infectious Diseases ◽

10.1093/ofid/ofz360.2419 ◽

2019 ◽

Vol 6 (Supplement_2) ◽

pp. S965-S966

Author(s):

Eili Klein ◽

Emily Schueller ◽

Katie K Tseng ◽

Arindam Nandi

Keyword(s):

United States ◽

Antibiotic Resistance ◽

Influenza Vaccination ◽

Vaccination Coverage ◽

Seasonal Influenza ◽

Antibiotic Use ◽

The United States ◽

Antibiotic Prescribing ◽

Coverage Rates ◽

The Impact

Abstract Background Antibiotic resistance is a cause of morbidity and mortality driven by inappropriate prescribing. In the United States, a third of all outpatient antibiotic prescriptions may be inappropriate. Seasonal influenza rates are significantly associated with antibiotic prescribing rates. The impact of influenza vaccination coverage on antibiotic prescribing is unknown. Methods We conducted a retrospective analysis of state-level vaccination coverage and antibiotic prescribing rates from 2010 to 2017. We used fixed effects regression to analyze the relationship between cumulative vaccine coverage rates for a season and the per capita number of prescriptions for systemic antibiotics for the corresponding season (January–March) controlling for temperature, poverty, healthcare infrastructure, population structure, and vaccine effectiveness. Results Rates of vaccination coverage ranged from 33% in Nevada to 52% in Rhode Island for the 2016–2017 season, while antibiotic use rates ranged from 25 prescriptions per 1,000 inhabitants in Alaska to 377 prescriptions per 1,000 inhabitants in West Virginia (Figure 1). Vaccination coverage rates were highly correlated with reduced prescribing rates, and controlling for other factors, we found that a one percent increase in the influenza vaccination rate was associated with 1.40 (95% CI: 2.22–0.57, P < 0.01) fewer antibiotic prescriptions per 1,000 inhabitants (Table 1). Increases in the vaccination coverage rate in the pediatric population (aged 0–18) had the strongest effect, followed by the elderly (aged 65+). Conclusion Vaccination can reduce morbidity and mortality from seasonal influenza. Though coverage rates are far below levels necessary to generate herd immunity, we found that higher coverage rates in a state were associated with lower antibiotic prescribing rates. While the effectiveness of the vaccine varies from year to year and the factors that drive antibiotic prescribing rates are multi-factorial, these results suggest that increased vaccination coverage for influenza would have significant benefit in terms of reducing antibiotic overuse and correspondingly antibiotic resistance. Disclosures All authors: No reported disclosures.

Download Full-text

Investigating Seasonal Influenza Vaccination Sites in the United States

Value in Health ◽

10.1016/j.jval.2016.03.1196 ◽

2016 ◽

Vol 19 (3) ◽

pp. A223

Author(s):

S Inguva ◽

BJ Patterson ◽

JM Sautter ◽

WF McGhan

Keyword(s):

United States ◽

Influenza Vaccination ◽

Seasonal Influenza ◽

The United States ◽

Seasonal Influenza Vaccination

Download Full-text

Strategies for Pandemic and Seasonal Influenza Vaccination of Schoolchildren in the United States

American Journal of Epidemiology ◽

10.1093/aje/kwp237 ◽

2009 ◽

Vol 170 (6) ◽

pp. 679-686 ◽

Cited By ~ 94

Author(s):

N. E. Basta ◽

D. L. Chao ◽

M. E. Halloran ◽

L. Matrajt ◽

I. M. Longini

Keyword(s):

United States ◽

Influenza Vaccination ◽

Seasonal Influenza ◽

The United States ◽

Seasonal Influenza Vaccination

Download Full-text

Determinants of Seasonal Influenza Vaccine Uptake Among the Elderly in the United States: A Systematic Review and Meta-Analysis

Gerontology and Geriatric Medicine ◽

10.1177/2333721419870345 ◽

2019 ◽

Vol 5 ◽

pp. 233372141987034 ◽

Cited By ~ 2

Author(s):

George N. Okoli ◽

Ahmed M. Abou-Setta ◽

Christine J. Neilson ◽

Ayman Chit ◽

Edward Thommes ◽

...

Keyword(s):

United States ◽

Health Insurance ◽

Influenza Vaccine ◽

Influenza Vaccination ◽

Seasonal Influenza ◽

The Elderly ◽

The United States ◽

Elderly Individuals ◽

Seasonal Influenza Vaccine ◽

Seasonal Influenza Vaccination

Background: Despite the availability of a universal influenza vaccination program in the United States and Canada, seasonal influenza vaccine (SIV) uptake among the elderly remains suboptimal. Understanding the factors that determine SIV uptake in this important population subgroup is essential for designing effective interventions to improve seasonal influenza vaccination among the elderly. We evaluated the determinants of SIV uptake in the elderly in the United States and Canada. Methods: We systematically searched relevant bibliographic databases and websites from 2000 to 2017 for population-based clinical trials or observational studies conducted in community-based elderly individuals in the United States or Canada, irrespective of health status. Two reviewers independently screened the identified citations for eligibility using a two-stage sifting approach to review the title/abstract and full-text article. We gathered data on determinants of uptake (any vaccine receipt) and adherence (receipt of vaccine in more than one season) to seasonal influenza vaccination. Where possible, we pooled the data using inverse variance methods to minimize the variance of the weighted average. Results: Five cross-sectional studies on SIV uptake (none on adherence) from the United States met our eligibility criteria. Being older (pooled odds ratio [POR] = 1.44, 95% Confidence Interval [CI] = 1.11, 1.86); White (POR = 1.33, 95% CI = [1.10, 1.64]); and having higher income (POR = 1.06, 95% CI = [1.04, 1.09]); and health insurance (POR = 1.40, 95% CI = [1.25, 1.55]) were associated with increased SIV uptake. Conclusion: Older, ethnically White, higher income elderly individuals with access to health insurance coverage and a regular health care provider have higher SIV uptake in the United States. There was limited evidence for other socioeconomic and health-related determinants. Further studies are needed to provide an evidence base for planning more effective influenza vaccination programs in the United States.

Download Full-text

Vaccination In Pregnancy Against Pertussis And Seasonal Influenza: Key Learnings And Components From High-Performing Vaccine Programmes In Three Countries: United Kingdom, The United States And Spain

10.21203/rs.3.rs-491336/v1 ◽

2021 ◽

Author(s):

Théophile Baïssas ◽

Florence Boisnard ◽

Inmaculada Cuesta Esteve ◽

Marta García Sánchez ◽

Christine E. Jones ◽

...

Keyword(s):

United States ◽

United Kingdom ◽

Influenza Vaccination ◽

Pregnant Women ◽

Seasonal Influenza ◽

The United States ◽

National Immunisation Programme ◽

Seasonal Influenza Vaccination ◽

High Performing ◽

In Pregnancy

Abstract Background: Pertussis and seasonal influenza are responsible for significant maternal, neonatal, and infant morbidity and mortality, but vaccine coverage rates (VCR) for both pertussis (administered as a tetanus, diphtheria, acellular pertussis [Tdap] vaccination) and seasonal influenza in pregnancy remain generally low. Only a small number of countries, including Spain, the United Kingdom (UK), and the United States of America (USA), have high Tdap and seasonal influenza VCRs in pregnancy. The purpose of this study was to identify the key factors that contributed to the high VCRs observed in these countries.Methods: The experience from both Tdap and seasonal influenza vaccination programmes during pregnancy were documented in Spain, the UK, and the USA using a three-step approach. A literature review yielded 157 publications, and a further 117 documents were selected through desk research. A published five-pillar VCR framework for influenza was amended to evaluate the specific contributing factors leading to high Tdap and seasonal influenza VCRs among pregnant women.Results: The analysis identified components that contributed to higher VCR in pregnant women across three different healthcare systems in Spain, UK, and USA. The combination of several key interventions in each country led to a rapid increase in VCR that reached near-optimal levels (i.e. 75% for seasonal influenza) within a few years. As well as inclusion in national immunisation programme and vaccine reimbursement, key components that were identified included the mobilisation of health authorities, prenatal care Healthcare Professionals (HCP) and scientific societies, the inclusion of vaccination in antenatal medical guidance, the provision of educational material to HCPs, and a strong disease awareness driven by recent pertussis outbreaks in each country.Conclusions: Although there is no simple, universal solution to improving sub-optimal VCRs, the list of components identified in this study from three countries with high-performing Tdap and seasonal influenza vaccination programmes provides a basis for public health and medical stakeholders in other countries to define strategies to successfully implement national vaccination programmes for pregnant women.

Download Full-text